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Dutasteride works the same way: by oral administration it accumulates peripherally (i.e. in skin) and reduces scalp DHT as per many research papers (DHT is mainly a paracrine hormone). However, I am not sure how prolactin is produced within the follicle. Dopaminergic drugs reduce PRL by increasing dopamine, but I am not sure whether the scalp contains dopamine receptors.Carbegoline does not target extra pituitary prolactin produced in the hair follicles so you will not have results from this.
The spikes in prolactin are promoted by an upregulation of estrogen activity.
The reason why it doesn't affect negatively your hair is because ERa is the one that promotes prolactin and the predominant receptor in hair follicles is ERb, which silences the actions of ERa. So you should actually have less extra pituitary prolactin damaging your hair while at the same time getting the benefits of upregulated ERb. In fact this scenario is what I am trying to replicate without using exogenous estrogen or unwanted sise effects.
There is also the topic of inflammation and its relation with DHT/androgens, and how it could potentially signal the motility of PRL/ PRLR containing macrophages. But I will leave that for now.
Yes I am currently taking Cyproheptadine. I take it orally and I agree, it's very versatil.
Also good luck with the Cyproheptadine. Amazing compound.
It do not think systemic concentrations (of a paracrine hormone) matter much when looking at a local problem. An individual can have low serum DHT but high scalp DHT, the same goes for PRL. The same does not hold for T, for example, because it is an endocrine hormone and is not produced locally in tissues (although tissue concentrations may still vary, and of course the testes are an exception). E2 is also a paracrine hormone, that is why I am always wondering whether the effects from oral E2 primarily come from its ability to suppress the gonads (or maybe even upregulation of aromatase, which increases local E2). I would guess high (or low) systemic concentrations of paracrine hormones have some effect, but ultimately it is the local concentrations that matter. Note that achieving a high systemic concentration of a paracrine hormone in absence of a high local concentration is only artificially possible through HRT.I know this. Either way it will reduce the systemic donation of prolactin, resulting in lower levels in the follicles.