Could someone please explain to me, if the possibility of the partial agonist effects of SAAs like CPA/spironolactone, it is capable of making the things worse? Reading older threads, some members mentioned that is somehow fifty-fifty chance, and I believe it's making sense since Testo/DHT it will still do damage. Although, as long as I have been looking for, the majority gets very good results with CPA/spironolactone without the adverse effects of the partial agonist on the AR. So, how much should someone need to take that under consideration?
**Directly from Wikipedia: Spironolactone, similarly to other steroidal antiandrogens such as cyproterone acetate, is actually not a pure, or silent, antagonist of the AR, but rather is a weak partial agonist with the capacity for both antagonistic and agonistic effects. However, in the presence of sufficiently high levels of potent full agonists like testosterone and DHT (the cases in which spironolactone is usually used even with regards to the "lower" relative levels present in females), spironolactone will behave more similarly to a pure antagonist. Nonetheless, there may still be a potential for spironolactone to produce androgenic effects in the body at sufficiently high dosages and/or in those with very low endogenous androgen concentrations.
Thank you very much in advance.