- Reaction score
- 3,025
Can confirm that this particular non responder to anti androgens is also a non responder to 1.5g seti daily
Seti by definition will in my opinion always be weaker than something like topical darolutamide for a myriad of reasons.
This is the mechanism for Seti:
Seti blocks one downstream inflammatory mediator of hairloss induced by androgen receptor binding. Only one. If you want a downstream anti-inflammatory, anti-histamines do this and more. I would love to see topical desloratadine vs. oral seti in a study. I think that would be an interesting matchup. The anti-histamine might be the underdog in that match but I bet it would be at least close.
By contrast, darolutamide in sufficient doses has the capacity to block all your androgen receptors so no androgen can even bind and no inflammatory cascade can begin.
These two approaches are not comparable.
The benefit of seti is that it may be much safer long term and may not have negative fertility or androgen deprivation side effects like daro. Androgen deprivation sides are no fun. Also, seti can be brought to market since it's safe for others, while using daro on your scalp will always turn you into a walking potential biohazard to others. "Warning: Do not touch scalp". "Do not touch anything scalp has touched". Topical daro can never be a commercial product. People should not use this in general.
I think seti is a good idea for people who want to steer clear of anti-androgens altogether by working completely downstream, at a trade-off likely of efficacy. If it is well proven in the studies, cheap, and safe, I would definitely give it a go as a way to reduce my daro dose.
As for you Georgie, I'm sorry to hear that, but I'm not surprised. I still hope you get better with a better estrogen balance, though as I've admitted to you before, that's just my hope. Time will tell. If not, then maybe your idea to try sulfasalazine down the road might not be bad, just in case the biopsies missed something.
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