losin_it said:
Winny profile: Strong gains are never really made while using stanozolol (it's a weak androgen since it has no 3-keto group needed for androgen binding) Winny is a weak androgen but how do you explain all the men that have complained about extensive hairloss while on it. Some saying the hair loss was worse than taking testosterone.
When you say "it's a weak androgen", what do you mean? Do you mean it has a low anabolic/androgenic ratio or do you mean it has a low AR binding affinity?
If we judge it in terms of anabolic/androgenic ratio there's no doubt that stanozolol (aka winstrol) is a great AAS with a very high dissociation index between anabolic and androgenic properties, in fact, it's about 30/1 (1). How can we explain then that an AAS with such a mild androgenic profile seems to be so harsh on the scalp? From my point of view, there might be the following explanations:
1) All those claims that winnie is harsh on the hair follicle don't come to us through scientific data, but rather through anectodal reports. Given their subjective nature, these anectodal reports might very well be just a bunch of bullshit/lies/misinterpretations; however, they might also be entirely true. We just don't know for sure (we can't).
2) In order to meaure a steroid's anabolic/androgenic ratio the method followed consisted of comparing the weight increases in ventral prostates of castrated rats versus the weitght of their levator ani muscle. On the one hand, these results might not be extrapolable to humans, on the other, measuring anabolic activity by means of weighing levator ani muscle is a method that has been strongly critizised. What I really mean is that the 30/1 figure MIGHT not be realiable at all. Again, we don't know (we can't), we'd need to do this kind of research on humans, which is highly unlikely to ever happen.
3) A certain steroid might prove very mild androgenically in terms of stimulating prostate growth, but that doesn't necessarily imply that it's going to show the same mildness in other tissues. Different androgens activate different genes and, while winstrol might be 100% mild as prostate growth is concerned (because it fails to activate at the nucleus ofcells those genes related to prostate growth), it MIGHT show a good ability when it comes to activating other genes at other tissues, for instance, when activating those genes related to male pattern baldness.
References:
1:1: J Allergy Clin Immunol. 1981 Sep;68(3):181-7
Clinical and biochemical effects of stanozolol therapy for hereditary angioedema.