No, they aren't enrolling yet
Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss
- Thread starter Ollie
- Start date
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- 342
The fact that HMI doesn't affect PRL levels is irrelevant since it silences the receptors. What difference does it make how much PRL you have circulating in your blood if there's no effect when it binds to the receptor. If there's a downside to no PRLR activation, you're gonna get it with HMI regardless of how much PRL you have in your blood. That's my understanding of it, anyway, but I'm not an expert on the topic.
Where'd you get this from???
They only tested on 29 people in phase I???
Where'd you get this from???
They only tested on 29 people in phase I???
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i found it in the bayer studies „BAY 1158061“
Pretty standard phase 1 trial sample size. The pyralutamide p1 had like 12 people.
They are not in the habit of rounding up hundreds of people to give previously untested drug compounds where safety is unknown.
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Where did you find the Bayer studies? Maybe they've been posted and discussed in the thread, but I missed it.
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Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women | Semantic Scholar
The PRLR antibody showed a favorable safety and tolerability profile in postmenopausal women with no distinct differences in occurrence of adverse events in BAY 1158061 or placebo-treated participants, considered a good candidate for further development in endometriosis or other PRL-mediated...
www.semanticscholar.org
look For „Table 3“
Can we expect the trial to start by may end?
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Thanks!Monoclonal Antibody Against Prolactin Receptor: A Randomized Placebo-Controlled Study Evaluating Safety, Tolerability, and Pharmacokinetics of Repeated Subcutaneous Administrations in Postmenopausal Women | Semantic Scholar
The PRLR antibody showed a favorable safety and tolerability profile in postmenopausal women with no distinct differences in occurrence of adverse events in BAY 1158061 or placebo-treated participants, considered a good candidate for further development in endometriosis or other PRL-mediated...
look For „Table 3“
So these are postmenopausal women, for whatever that's worth with regards to possible differences in sides between men and women.
Yes, there are certainly sex differences in sides for anything related to hormones. For example, prolactin is more important in bile production for men.
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Based on?
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Oh ya. I saw that. This sh*t is like super super super super super old news. I need to see human studies. The moment we see a human study on a man with the same success. We can all finally rest and drop our guns and live. .
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For some on here, hair loss is only one small part of their issues. There are some truly deranged individuals on here, and no amount of hair will fix all of their problems.
For me personally, it would be great to never have to worry about hair loss effecting my life ever again, but I think people do overstate the importance or impact it will have.
For example, when I was younger I had really crooked bottom teeth and big sticky out upper front teeth with pointy canines thrown in for good measure. At the time it completely crippled my confidence (age 18-27), but then I got Invisalign and had them reshaped so have a nearly perfect set of teeth. I don't ever think back to the days of crooked teeth even though at the time it was all I could think of and I remember being desperate and embarrassed about it.
And like I said, I literally never think about those days now (I'm 39), I think the same could be said for a "cure" for hair loss. I think some people are imagining their life will improve immeasurably and their entire personas will be completely different if they didn't have to deal with hair loss, but sadly I don't think it'll be the case.
The picture was released last year on Chinese social media. It is from the study that is referenced in the Bayer patent. The study was conducted sometime before 2016.
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Do you think that Bayer and FUE can be some sort of a cure?
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Maybe I sound like a broken record with this line, but I'm not sure we're home free even if HMI turns out to work in humans the same way as in the monkeys, because a) there's still the question of how long until it's available and b), more importantly, the question of how much it is going to cost and whether it's gonna be in our financial reach at all.
That's why it would be great to find some SMI that could work, be available immediately and cheaper.
Finally some progress!! One question: Does estimated study completion in 2024 mean, that all 3 Phases are finished?
The US isn't requiring a phase I, so they won't be updating this with a US location. The best we can hope for is that they start phase II in the US without waiting for this Phase I to complete. Must be a woman in charge at TGA in Aus, or a NW0. No sympathy for baldies.