The simple answer is that we know how treatments like finasteride and minoxidil affect macaques, and if we see the same replication from macaque to human head that we have seen in the past with these substances, then we can easily expect this to be superior than any hair loss drug by an order of magnitudes.
Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss
- Thread starter Ollie
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The simple answer is that we know how treatments like finasteride and minoxidil affect macaques, and if we see the same replication from macaque to human head that we have seen in the past with these substances, then we can easily expect this to be superior than any hair loss drug by an order of magnitudes.
Animal models are constructed to mimic conditions that would be found on a human. For mouse models, it's not very conducive to being replicated on humans because mice don't have androgen related hairloss, so they just study how quick the hair regrows or if it grows at all on a nude mouse.
For stump-tailed macaques, they literally have androgen related hairloss. Most drugs you've heard of (finasteride, minoxodil, RU) were successful on the macaque model and pretty much translated 1:1 or better on humans (except for RU which no human data was published so we don't know). If you could find me a drug that worked on the model that didn't work in humans I'd love to see it (I dont think one exists), it's a very expensive animal model that is really only used when the researchers have high confidence.
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how it can cause ED? it should have opposite effect
"Elevated PRL is associated with impairment of the hypothalamic-pituitary-gonadal axis.29 In the central nervous system, hyperprolactinemia inhibits centers that control sexual desire and erection"
Effect of prolactin on penile erection: a cross-sectional study - PMC
Although elevated prolactin levels have been shown to inhibit penile erection, the relationship between prolactin and erection of the penile tip or base has not been extensively researched. We therefore investigated the prolactin's effects on ...www.ncbi.nlm.nih.gov
so does HMI-115 lower the prolactin Level in Human?
So, if this drug translate good on human trials, so it should be ’cure’ for most of the guys?
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no it will not effect circulating PRL levels . thats why this treatment will be so good. It only show really high specificity to the PRL receptor in hair follicle and some other tissues) to block its signaling. All new successful medicines have been biologics lately
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So If you say so then HMI-115 won‘t do anything regarding ED or high Sex drive.
don’t get me wrong, i am
Happy If HMI-115 has No Side effects. But First you told it would give high potency and now you say that it don’t Effect circulating PRL Levels.
No offense!
I think it would raise it, if anything. It blocks binding to receptors to there would be more in the serum.
Similar to how you get a slight rise in T by blocking 5ar to create DHT.
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sorry i dont understand that one
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So and If it raises the prolactin then what would that mean regarding sexual aspects?
A) erectyle dysfunction or B) higher Sex Drive/ better erections?
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it would not raise it out of homeostatic range. It happen with all drugs when you antagonize a receptor you see a small increase in its endogenous ligand. We will know after phase 2 what kind of safety profile HMI have but i am really hopeful that its gonna be safe
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This was the safety profile of Phase I (HMI-115)
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it seems like the major ones are GI , and headaches at the 60mg dose and fatigue at the 90mg dose. nothing really severe pops out here and this are pretty common to many more drug regimens out there. Plus they didn't really test it only many people. the sample size is less than 10 at each dosing interval. Its really well tolerated by the liver and kidney according to this
Can confirm
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any improvement hairwise ? thanks
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is that based on the smi trial that was done by some members ?- Reaction score
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Man, did you get into the HMI trial?