all you RU people
- Thread starter CCS
- Start date
Everyone thank squeegee
http://www.herbalextractsplus.com/licorice.cfm
1/4 pound = 110g of 20% extract for $17. Now that is a deal. he also found a study showing that the main sweetening ingredient plays a key role in the 5ar inhibition. Maybe it is not the only chemical, but it definitely is one of the big players, and shows that we may not need the inflata.
http://www.herbalextractsplus.com/licorice.cfm
1/4 pound = 110g of 20% extract for $17. Now that is a deal. he also found a study showing that the main sweetening ingredient plays a key role in the 5ar inhibition. Maybe it is not the only chemical, but it definitely is one of the big players, and shows that we may not need the inflata.
A 10% glycyrrhizin shampoo prevented sebum secretion for 1 week compared with citric acid shampoo, which delayed oil accumulation by 1 day.
http://www.drugs.com/npp/licorice.html
PREVENTED!!! NOT REDUCED. PREVENTED, FOR 1 WEEEK, SEBUM EXCRETION!!!!
http://www.drugs.com/npp/licorice.html
PREVENTED!!! NOT REDUCED. PREVENTED, FOR 1 WEEEK, SEBUM EXCRETION!!!!
squeegee found this:
The effects of the licorice derivative, glycyrrhetinic acid, on hepatic 3 alpha- and 3 beta-hydroxysteroid dehydrogenases and 5 alpha- and 5 beta-reductase pathways of metabolism of aldosterone in male rats.
Ingestion of licorice or treatment with chemical derivatives of glycyrrhetinic acid (GA), an active principle of licorice, can cause hypertension, sodium retention, and hypokalemia. Although GA has been shown to inhibit 11 beta-hydroxysteroid dehydrogenase, it may not be the only hepatic enzyme affected by this licorice derivative. Therefore, we studied the effects of GA on other major hepatic steroid-metabolizing enzymes from adrenalectomized male rats using aldosterone as the substrate; namely, delta 4-5 alpha- and delta 4-5 beta-reductases and 3 alpha- and 3 beta-hydroxysteroid dehydrogenases (3 alpha- and 3 beta-HSD). From these in vitro studies, we demonstrated that GA does not affect either microsomal 5 alpha-reductase or cytosolic 3 alpha-HSD activity. However, GA is a potent inhibitor of cytosolic 5 beta-reductase; the K(is) and K(ii) were calculated from enzyme kinetic analysis to be 6.79 and 5.41 microM, respectively, using the Cleland equation, indicating that GA is a noncompetitive inhibitor of aldosterone. In addition, GA specifically inhibited microsomal 3 beta-HSD enzyme activity by what appears to be a competitive inhibition mechanism, causing a build-up of the intermediate, 5 alpha-dihydroaldosterone (DHAldo). Thus, this study has indicated that GA has a profound effect on hepatic ring A-reduction of aldosterone. Inhibition of 5 beta-reductase and 3 beta-HSD results in decreased synthesis of both 3 alpha, 5 beta-tetrahydroaldosterone (THAldo) and 3 beta, 5 alpha-THAldo and, hence, accumulation of aldosterone and 5 alpha-DHAldo, both potent mineralocorticoids.
Ok lot of blabla but I think a got my answer: Inhibition of PKC activity was nearly 100% with glycyrrhetinic acid glycoside (glycyrrhizine) at 200 ?M; and 52% with 18/5- glycyrrhetinic acid at 500 ?M.
http://www.wipo.int/pctdb/en/wo.jsp?WO= ... SPLAY=DESC INHIBITION OF HAIR GROWTH
Glycyrrhetinic acid is the major active component..It is what we want so far...from the Licorice root.
The effects of the licorice derivative, glycyrrhetinic acid, on hepatic 3 alpha- and 3 beta-hydroxysteroid dehydrogenases and 5 alpha- and 5 beta-reductase pathways of metabolism of aldosterone in male rats.
Ingestion of licorice or treatment with chemical derivatives of glycyrrhetinic acid (GA), an active principle of licorice, can cause hypertension, sodium retention, and hypokalemia. Although GA has been shown to inhibit 11 beta-hydroxysteroid dehydrogenase, it may not be the only hepatic enzyme affected by this licorice derivative. Therefore, we studied the effects of GA on other major hepatic steroid-metabolizing enzymes from adrenalectomized male rats using aldosterone as the substrate; namely, delta 4-5 alpha- and delta 4-5 beta-reductases and 3 alpha- and 3 beta-hydroxysteroid dehydrogenases (3 alpha- and 3 beta-HSD). From these in vitro studies, we demonstrated that GA does not affect either microsomal 5 alpha-reductase or cytosolic 3 alpha-HSD activity. However, GA is a potent inhibitor of cytosolic 5 beta-reductase; the K(is) and K(ii) were calculated from enzyme kinetic analysis to be 6.79 and 5.41 microM, respectively, using the Cleland equation, indicating that GA is a noncompetitive inhibitor of aldosterone. In addition, GA specifically inhibited microsomal 3 beta-HSD enzyme activity by what appears to be a competitive inhibition mechanism, causing a build-up of the intermediate, 5 alpha-dihydroaldosterone (DHAldo). Thus, this study has indicated that GA has a profound effect on hepatic ring A-reduction of aldosterone. Inhibition of 5 beta-reductase and 3 beta-HSD results in decreased synthesis of both 3 alpha, 5 beta-tetrahydroaldosterone (THAldo) and 3 beta, 5 alpha-THAldo and, hence, accumulation of aldosterone and 5 alpha-DHAldo, both potent mineralocorticoids.
Ok lot of blabla but I think a got my answer: Inhibition of PKC activity was nearly 100% with glycyrrhetinic acid glycoside (glycyrrhizine) at 200 ?M; and 52% with 18/5- glycyrrhetinic acid at 500 ?M.
http://www.wipo.int/pctdb/en/wo.jsp?WO= ... SPLAY=DESC INHIBITION OF HAIR GROWTH
Glycyrrhetinic acid is the major active component..It is what we want so far...from the Licorice root.
Bulk ingredient
http://www.herbalextractsplus.com/licorice.cfm
Studies posted in Experimental forum and New Research forum.
Pre-made shampoo
http://www.google.com/search?client=fir ... gle+Search
http://www.herbalextractsplus.com/licorice.cfm
Studies posted in Experimental forum and New Research forum.
Pre-made shampoo
http://www.google.com/search?client=fir ... gle+Search
You guys are awesome, I just ordered the 1/4 not 5 minutes ago. Definitely going to give this a try.
Am I hearing this correctly? Add to shampoo and hopefully VOILA!!?
Well, not to that extent but you know what I mean.
Also, could you add this to the white curcumin concoction? Ethyl Alcohol, white curcumin, licorice and???
Am I hearing this correctly? Add to shampoo and hopefully VOILA!!?
Well, not to that extent but you know what I mean.
Also, could you add this to the white curcumin concoction? Ethyl Alcohol, white curcumin, licorice and???
unk: 
squeegee
Banned
- Reaction score
- 132
More website where you can get the Glycyrrhiza glabra in Bulk Powder:
http://www.1stchineseherbs.com/chinese_g.html
http://www.herbco.com/bulk_herbs/bulk-herbs-hair loss.php
http://www.healthyvillage.com/product_list/25.html
http://www.1stchineseherbs.com/chinese_g.html
http://www.herbco.com/bulk_herbs/bulk-herbs-hair loss.php
http://www.healthyvillage.com/product_list/25.html
ripple-effect
Experienced Member
- Reaction score
- 11
Show me tha Lic-o-rice!!!
Yuber
Member
- Reaction score
- 0
I just e-mailed a company that have Minimum 98% of Glycyrrhizic Acid(by UV),
Minimum 60% of Glycyrrhizic Acid(by HPLC).
http://www.tokiwaph.co.jp/products/prod ... orice.html
http://www.tokiwaph.co.jp/products/prod ... orice.html <----effects of the different Glycyrrhizic acids.
They have studies of plants hidden abilities. I asked if they had any studys on Glycyrrhizic Acid on hairloss, and if they are interested in selling some of the powder cause the have inflata too.
I found a spray with Glycyrrhizic acid. It's for Herpes.
Main ingredient: Glycyrrhizic Acid
Polysorbate 80
Propylene
Glycol
Ascorbic Acid
Folic Acid
Aqua
Malic Acid
Fumaric Acid
http://www.aacstore.net/Merchant2/merch ... streatment
A bit interesting to see that besides Glycyrrhizic acid it includes other ingredients that has been discussed used for hairloss.
Anyway it's a no go because all the ingredients would make it hard to tell what Glycyrrhizic acid does alone.
Minimum 60% of Glycyrrhizic Acid(by HPLC).
http://www.tokiwaph.co.jp/products/prod ... orice.html
http://www.tokiwaph.co.jp/products/prod ... orice.html <----effects of the different Glycyrrhizic acids.
They have studies of plants hidden abilities. I asked if they had any studys on Glycyrrhizic Acid on hairloss, and if they are interested in selling some of the powder cause the have inflata too.
I found a spray with Glycyrrhizic acid. It's for Herpes.
Main ingredient: Glycyrrhizic Acid
Polysorbate 80
Propylene
Glycol
Ascorbic Acid
Folic Acid
Aqua
Malic Acid
Fumaric Acid
http://www.aacstore.net/Merchant2/merch ... streatment
A bit interesting to see that besides Glycyrrhizic acid it includes other ingredients that has been discussed used for hairloss.
Anyway it's a no go because all the ingredients would make it hard to tell what Glycyrrhizic acid does alone.
squeegee said:I think I just found a supplier of the Glycyrrhiza inflata Bat. in California..Waiting for the answer....
Glycyrrhiza inflata
Glycyrrhiza glabra
Fantastic work. It also matters what they used to extract it. I think we got what we need, but it would be nice to know we got the best. But for all we know, maybe a water extract is ever stronger than the polyol extract. But what are the odds of that?