I don't know if you are trying to be funny by bumping an old thread. If not, setipiprant did not show good results for Androgenetic Alopecia and fevipiprant will likely never be released.
You still need the sulfotransferase enzyme for oral minoxidil to work properly. "Oral minoxidil bio-activation by hair follicle outer root sheath cell sulfotransferase enzymes predicts clinical efficacy in female pattern hair loss"
Actually, dutasteride in combination with finasteride can perform better than dutasteride alone. Some doctors use this combination in their patients and some people report the strong benefit of combining these two drugs https://www.ncbi.nlm.nih.gov/pubmed/22686691
As for your issue, I would get...
What the heck, I feel like no one used to talk about oral minoxidil. Now in 2019, I feel like everyone is lololol. It is great, I have been using it since Oct/Nov 2017 without sides. 2.5mg a day. 5mg a day seems to be safe as well, but I will stick to 2.5mg. 1mg has also been shown to be effective.
The itchiness or "dermatitis" from Minoxidil is not caused by it's vasodilation effect. It is caused from minoxidil being a skin irritant on its own. If your minoxidil has PG or another irritating vehicle, it will be even worse. I used Minoxidil without PG and I still had the worst dandruff...
It will most likely work for a short period of time, and then a couple years later you will be back to baseline. It depends on how aggressive your hair loss is and how well you respond to the treatment. I am not sure exactly what you mean by "anti inflammatory and growth stimulant." The first...
Hi James,
I think you are right, but I am not sure. It seems the PTGDS angle is still alive, but I wonder if any company will pursue it. Maybe inhibiting PTGDS is too unsafe. Or hard to do. I don't know. Here is the quote from a 2/2019 study for those that have not seen it yet "It has been...
I believe the file I attached is this study, sorry if it is not. Let's discuss it. I wrote this about it in another thread: "The earlier studies on PGD2 in male pattern baldness such as this one https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982925/ as well as the one you posted
suggest that...
The earlier studies on PGD2 in male pattern baldness such as this one https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982925/ as well as the one you posted
suggest that inhibiting PTGDS (aka PGD2 synthase) could work to prevent and treat male pattern baldness. I know that tretinoin inhibits PTGDS and has been shown clinically to...
Hello, I am not sure exactly what you are asking. Cetirizine has been shown to somewhat inhibit PGD2. It does not inhibit the CRTH2/GPR44 receptor like Setipiprant, Fevipiprant, and OC000459 do. Or it at least has not been shown to do that. Some people also believe cetirizine increases PGE2...
I think this quote that was posted by another user about another study (I can't find the study) tells us why Fevi won't work either
.Apparently it is from a study published February 2019
"It has been suggested that inhibitors of PTGDR2 may reverse hair growth through inhibition by PGD2...