That study was based on rats. I don't feeling like finding the research myself, but there were findings from scientist's biopsies of people taking dht-inhibitors that there were a marked increased in androgen-receptors in the scalp follicles. Scour these forums and other hair loss forums, and you'll find plenty of anecdotal stories that support this. I myself have experienced it. It is a real thing.
I'm like 99% positive upregulation, which is basically just a fancy way of saying increased sensitivity to androgens, is a real thing. I mean. Think about it. When we're in our teens, when we have the highest concentration of testosterone in our system, our hair is much less sensitive to the androgens, but as we get older, usually starts in our 20s, we become more sensitive to the androgens and start recede/thin/bald.
but for me I lost hair rapidly right after puberty in my teens and then hairloss progressed slowly after that. but then again the norwood 2 and 3 area is more sensitive generally.
HT is also significantly less. They probably also don't have as many receptors on average. This is why the vast majority of female bodybuilders taking steroids still have full-heads of hair with no significant recession. Males on the other hand...
women have more aromatse in the temple regions of the scalp, which is why when T makes its way there it can actually be a good thing, lol. I have also heard that bald men have less adipose fat in their scalp than fullheads, Im not sure how true that is. but it would make sense since body fat is a source of aromatse.That is an interesting theory. It very well could be. A significant spike could illicit a response that increases follicular androgen receptor uptake. I think it all boils down to how sensitive, meaning how many androgen receptors, your scalp follicles have. I've known, have friends, that take steroids that still have perfect hairlines. I'm talking about Zayn Malik, Brad Pitt type hair. Others that drastically thinned/balded whilst on it. Age can definitely be a factor. But I think as men, our scalp follicles are definitely more prone. DHT is 40 times more potent of an androgen than testosterone, and it is a byproduct of a small amount(I believe 10%) of the total testosterone we have circulating in our system. Women, on average, produce much less testosterone, and therefore much less DHT. I'm not sure, but it'd be safe to assume that their conversion ratios of T
Technically with the condition I have, I suffer from androgen deficiency, as well as estrogen/test etc being too low. Androgen sensitivity isn’t th issue, it’s DHT. Literally the smallest amount has fucked me over. I also have eyelash and eyebrow loss, so it’s not androgens that are hurting me, since they are good for facial hair growth.
Basically I have what am innumerable number of men and women who have been through eating disorders/excessive exercise have in terms of hormonal imbalance. My issue is my extreme dht sensitivity and genetic predisposition
DHT is an androgen, though. Much, much more potent than test, and not only that it binds A LOT easier and longer to the hair follicles than test. And if you have a lot of androgen receptors, it will make you significantly more sensitive to DHT-- even if you have low levels of it. Over time, this adds up, and it will wreak havoc on your head.
I recently got my test levels done and they are low. My entire sex hormone profile is suppressed.
Jesus. I have no idea what to say. Have you tried derma-rolling combined with minoxidil? I even derma roll for my skin to counter any negative skin effects from minoxidil. I have some pictures of strong terminal hairs growing along my hairline that only grew after derma + minoxidil, but my camera blows.
Yes i derma roll once a week, and I have been taking 2mg oral minoxidil + 2 x 5% topical minoxidil + the pill diane35 since 2015 and also did the spironolactone for 9 months. I will say that my hairline receded like a mans to a NW2, I had/have eyebrow, eyelash and diffuse scalp thinning Also, and the minoxidil regrew an insane amount of hair and restored my hairline. I know it was the minoxidil because I had been on the pill and spironolactone for a while before I tried minoxidil and my hairline was only getting worse and worse. minoxidil really helped my brows, hairline and eyelashes, but there is still a steady decline happening. I do have this bizarre 3 month regrowth and recession though, and each time ktime hair grows back, it is thinner and there is less of it. Hence the dutas/RU now.
not necessarily, regrowth happens with extreme regimens. Some get good results with corticosteriods and those thin the skin.
what?! it does?
Yeah. Men can get hypogonadotrophic hypogonadism (what I have) from marathon running etc. just means low as f*** test.
oh probably from too much stress on their body, not sure if that would be good for hair in that case >.<
It’s causes my cortisol by the way. Overproduction of.
Exactly. Stress.
Whilst I’m on the pill I can’t because it artificially raises SBHG.