Hi all,
@Pigeon posted that the user @Mustang is currently having success with an extremely low dosage of topical Dutasteride. He said the following:
I did some research on the topic and there seems to be a valid hypothesis going around regarding why topical dutasteride might actually be safer compared to oral (and even topical) finasteride.
"The idea behind topical dutasteride has to do with the chemical properties compared to finasteride. At the molecular level, dutasteride is more difficult to deliver as a topical agent to be absorbed through the skin due to the size of dutasteride molecules. They are larger than those of finasteride. This difficulty however becomes an advantage as the difficulty to get past the subcutaneous layer may prevent systemic absorption. The molecular size prevents deep penetration. In addition, dutasteride has a high lipophilicity of 4.94, compared to 3.03 of finasteride, which means it is less water soluble than finasteride or more “greasy”. This higher lipophilicity can in theory help dutasteride to remain in the skin longer as these properties tend to preclude the paracellular and follicular routes of ingress into the skin."
https://fuehairdoctor.co.uk/topical-dutasteride-dr-lupanzula/
Any other people here that used topical dutasteride and want to share their experiences?
Thought in general?
@Pigeon posted that the user @Mustang is currently having success with an extremely low dosage of topical Dutasteride. He said the following:
Go topical dutasteride
I have been on it for 3 months now. Completely stopped my hair loss and zero side effects as compared with oral finasteride which was not as effective.
Best part is I only apply 2ml once a month. Half-life of the drug is so long that you don't need daily usage.
I did some research on the topic and there seems to be a valid hypothesis going around regarding why topical dutasteride might actually be safer compared to oral (and even topical) finasteride.
"The idea behind topical dutasteride has to do with the chemical properties compared to finasteride. At the molecular level, dutasteride is more difficult to deliver as a topical agent to be absorbed through the skin due to the size of dutasteride molecules. They are larger than those of finasteride. This difficulty however becomes an advantage as the difficulty to get past the subcutaneous layer may prevent systemic absorption. The molecular size prevents deep penetration. In addition, dutasteride has a high lipophilicity of 4.94, compared to 3.03 of finasteride, which means it is less water soluble than finasteride or more “greasy”. This higher lipophilicity can in theory help dutasteride to remain in the skin longer as these properties tend to preclude the paracellular and follicular routes of ingress into the skin."
https://fuehairdoctor.co.uk/topical-dutasteride-dr-lupanzula/
Any other people here that used topical dutasteride and want to share their experiences?
Thought in general?
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