Discussion in 'New Research, Studies, and Technologies' started by ZenHead, Oct 10, 2018.
these hundreds of pages can be summarised in few posts, this is one of them
Hello, any good experience microneedling with mid-long hair vertex/crown area? protocol recomendations?
thanks a lot
Would this be more effective for maintenance too?
That’s really good to know thank you.
Would you say the shed or any other side effects on minoxidil with microneedling would be worse than without?
Anyone microneedling with other products such as tricomin, revivogen etc?
Essentially this is true, despite Follica saying needling alone causes follicle neogenesis. But really it's Minoxidil responsible for any positive changes.
When you think about it, its quite ridiculous that this revolutionary new treatment is literally nothing more than wounding and minoxidil lol
but how come a previous non responder will become a responder combined with microneedling. Absorption is normally not a problem right? Especially if you had a shed from minoxidil alone
The mechanism isn't fully understood yet, but it's clear that there is a synergistic relationship between the two treatments.
Microneedling improves minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzyme
I read dermarolling without minoxidil is pretty much like pissing in the ocean.
also, what the user means with "Oral minoxidil also can convert non-responders to responders." is that our liver is rich in terms of sulfotransferase enzyme.
btw dont remember who, but someone posted a study about sodium bicarbonate (2ml per day) which should change the pHi of the ORS and stimulate follicular sulfotransferase activity (= boost minoxidil)
Wouldn't minoxidil sulfate work better
Sure but it's not stable in solution
Mixing it daily?
Go for it. They say its also more likely to irritate skin though
Yup, did it only for 6 months as an experiment. Didn't help at all and more guys did itt, all same results.
I doubt that. I think that comes from the idea that you have to use more penetration enhancers to penetrate the scalp because the molecular weight is higher. The molecular weight is under 500 daltons though, so it should penetrate fine.
The problem is, as you said, instability in solution. When I looked into it I found it should be stable enough for weekly batches in ethanol and pg. Worst case scenario it just degrades to regular minoxidil, so it's really a no brainer. The only reason I am not using it is because you need to mix it separately from any of your other compounds because when it degrades the sulfuric acid that's released may degrade the other molecules in your solution.
Has anyone noticed a general theme of success being from a certain length/frequency? I’ve seen it all over the board. Personally I do it every 2 weeks at 1.5 but that’s just cause I’m lazy. But if there is more success with every week I might bite the bullet.
I've read so many things on this I am confused myself.
Just blindly quoting the literature on that one I'm not sure how much substance there is to it. I'd consider it too if I move to topical but if you're already a minoxidil responder it's hard to justify the extra steps.
Well if this is indeed true (not claiming it is) then surely the only reason microneedling + minoxidil is working is by enhancing follicular sulfotransferase activity...
If this is indeed the case then surely we should also just use less invasive hair loss treatments, i.e instead of microneedling + minoxidil we'd try minoxidil + tretinoin or perhaps when it's released minoxidil + Applied Biology's upcoming topical minoxidil adjuvant therapy AB-103?
Why is it surely the only reason? It's surely the only reason if upregulating sulfotransferase is surely the only thing that needling accomplishes.