In some of the dutasteride mesotherapy studies I noticed that it lowered fertility..sperm counts, mobility etc...that's a concern for me.You don't want it to penetrate , that is the entire point. It should be degraded or prevented from reaching the hypodermis and vascularizing but reach the dermis.
I did a scalp biopsy and my DHT was almost non existent on my scalp while I had low-normal levels in my blood.
This is ideal.