Topical Dutasteride Case Assessment Thread

losingbattle88

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Do you happen to know the composition because it's 55 e for 60ml while farmaci andora sells 100ml with latanoprost for 40 ?
well I havent checked andora at all. but I know fue clinic use Trichosol which is safer cause it dont contain pg/alcohol that can go systemic alot more. and ofc it contains growth factors and vitamins which sounds good enough to me. 100ml for 40 sounds like a scam lol. xD
 

jd_uk

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strange perhaps but we all react differently to experimental chemicals made in china lol. like I said a guy here on this thread had the same thinning experience as me and his hair didnt regrow either. and I have read many people on reddit complaining that RU thinned their hair too not even joking I done alot of research, even my friends hairline vanished on RU. but now to your question. spironolactone is considered weaker than RU and CB I guess but the very admin of this forum has used topical spironolactone for 18 years and has maintained his hair. the molcular mass of spironolactone is pretty small like 416 so it will definately penetrate your skin. and yes spironolactone and alfadratiol is x10 times safer than RU and CB. I had sides on RU chest pressure and a pressure feeling above my adams apple. my regimen will actually be topical dutasteride with alfadratiol/spironolactone/aceliac acid/ and possibly minoxidil.
Thanks. Maybe when CB officially comes out as breezula it might be safer?

What would you say is the best way to get some hair benefit topically without systemic activity (e.g. lowerint DHT or free test) etc?
 

TanDoc

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You want to reduce inflammation. I was on low dose TRT (100mg a week) with zero DHT (oral dutasteride and topical dutasteride) and my hair went to hell. That's T for you.

Solution is to use CB0301 as a Topical anti-androgen at 7.5% concentration and reduce scalp DHT to a minimum with Topical Dutasteride and potentially Dutasteride Mesotherapy as well as increase scalp blood flow with oral minoxidil, laser level cap or topical minoxidil. That's all we have right now.

Androgenic alopecia is cause by inflammation. DHT happens to be increased with inflammation along with other androgens.

"Androgen activity can be a response to inflammation, and that tension-mediated inflammation may increase DHT, AR, and TGF-β1 in Androgenetic Alopecia by inducing ROS and other pro-inflammatory biomarkers."
The underlined part: that is a total hypothetical, the beginning of the title of the "paper" you're quoting from is "A hypothetical pathogenesis model for androgenic alopecia", from a fairly unreputable journal called "Medical Hypotheses". The journal is not really peer-reviewed, this is not a study in any way (he cherry-picks a few studies from other people to spread his hypothesis), and the author has no scientific background.

He is a guy, presenting his hypothesis, without having conducted an experiment.

I'm not saying the paper is entirely worthless (just mostly so), but please don't present this as some kind of hard fact or scientific evidence.

And if you actually read his paper, you'll see it's mostly a bunch of bullshit hypotheticals from a guy who cherry-picks (and mis-interprets studies) how he wants to support his personal idea. And of course the author's "conclusion" is that "scalp tension" causes inflammation, which causes more androgenic activity, which causes hair loss. And of course, if you sign up on the author's personal websites, he will sell you the secrets to fighting this!

He also calls himself a "researcher and medical editor" (with no science background whatsoever) and he sells his "hair loss cure" program of course :rolleyes:

Give me a break.
 

TanDoc

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You want to reduce inflammation. I was on low dose TRT (100mg a week) with zero DHT (oral dutasteride and topical dutasteride) and my hair went to hell. That's T for you.

Solution is to use CB0301 as a Topical anti-androgen at 7.5% concentration and reduce scalp DHT to a minimum with Topical Dutasteride and potentially Dutasteride Mesotherapy as well as increase scalp blood flow with oral minoxidil, laser level cap or topical minoxidil. That's all we have right now.
Your personal experience is a bit of an outlier compared to most men. The data shows that men with normal physiological testosterone levels and tanked DHT do not so rapidly lose hair like you describe.
 

TanDoc

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Solution is to use CB0301 as a Topical anti-androgen at 7.5% concentration and reduce scalp DHT to a minimum with Topical Dutasteride and potentially Dutasteride Mesotherapy as well as increase scalp blood flow with oral minoxidil, laser level cap or topical minoxidil. That's all we have right now.
What are your experiences with dutasteride mesotherapy and clascoterone (CB0301)?? Are you using in conjunction with topical duta?
 

MedicinallyCompetent

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Does anyone have any suggestions for accessing topical dutasteride in Canada?

Similarly - do we have any evidence to suggest that it's better to use a liposomal delivery compared with a PG/Ethanol system?

For the guys making this themselves - do dutasteride tablets easily dissolve in a solution of PG/Ethanol or Trichosol on their own?

Additionally, can someone send me the discord link? Thanks.
 
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Mustang

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What are your experiences with dutasteride mesotherapy and clascoterone (CB0301)?? Are you using in conjunction with topical duta?

I am not currently using it. I will try CB 7.5% on my next T cycle (June-August) and see if I have better luck protecting my hair.

Dutasteride mesotherapy is extremely effective specially when used with D panthenol, IF-1, Pyridoxine and Biotin. It has an 80% percieved improvement rate vs 30% improvement if using only Dutasteride according to this publication : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596657/ (They did use a higher concentration though)

The Topical Dutasteride I use (0.1%) from FUE CLINIC also has those vitamins and growth factors. I have seen more progress since switching to it the past 6 months compared to other formulations but most importantly the sides went away. Since it doesn't have DMSO it is much safer for me. DMSO is extremely effective in penetrating the scalp and I had horrible sides with it. I also has no alcohol as a solution which is a godsend to me since my scalp get's easily irritated with anything containing alcohol

The only downside is they are a little slow with answering emails and shipments, sometimes it takes up to 4 days to get a response and I know them.
 
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Mustang

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Your personal experience is a bit of an outlier compared to most men. The data shows that men with normal physiological testosterone levels and tanked DHT do not so rapidly lose hair like you describe.

My anecdotal evidence is in line with a couple of friends who have experienced the same with TRT (if not all of them) while tanking their DHT with oral dutasteride. TRT is not physiological regardless of the dose as it eliminates natural fluctuation.

Every single surgeon I have been to for a hair transplant (about 8 of them by now, including Couto, Feriduni Mwamba, Keser, HLC) has told me AA is caused by inflammation and explained how and why.
 

constrictedvoid

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I am not currently using it. I will try CB 7.5% on my next T cycle (June-August) and see if I have better luck protecting my hair.

Dutasteride mesotherapy is extremely effective specially when used with D panthenol, IF-1, Pyridoxine and Biotin. It has an 80% percieved improvement rate vs 30% improvement if using only Dutasteride according to this publication : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596657/

The Topical Dutasteride I use (0.1%) from FUE CLINIC also has those vitamins and growth factors. I have seen more progress since switching to it the past 6 months compared to other formulations but most importantly the sides went away. Since it doesn't have DMSO it is much safer for me. DMSO is extremely effective in penetrating the scalp and I had horrible sides with it. I also has no alcohol as a solution which is a godsend to me since my scalp get's easily irritated with anything containing alcohol

The only downside is they are a little slow with answering emails and shipments, sometimes it takes up to 4 days to get a response and I know them.
Do you think it may be possible to get them to make a weaker formulation? Maybe 0.05, 0.02 or even 0.01%?
 

lasfourmos

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well I havent checked andora at all. but I know fue clinic use Trichosol which is safer cause it dont contain pg/alcohol that can go systemic alot more. and ofc it contains growth factors and vitamins which sounds good enough to me. 100ml for 40 sounds like a scam lol. xD
Well i will give it a try then , andora also use trichosol in its preparation. I was just curious about the groth factor they are using in fue ( i am always suspicious about the composition of the things i buy )
 

Mustang

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Well i will give it a try then , andora also use trichosol in its preparation. I was just curious about the groth factor they are using in fue ( i am always suspicious about the composition of the things i buy )

I am pretty sure it's made in the same pharmacy. The only difference is volume, concentration and the extra compounds used on the preparation by FUECLINIC which make it more expensive by ml though.
 

losingbattle88

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My anecdotal evidence is in line with a couple of friends who have experienced the same with TRT (if not all of them) while tanking their DHT with oral dutasteride. TRT is not physiological regardless of the dose as it eliminates natural fluctuation.

Every single surgeon I have been to for a hair transplant (about 8 of them by now, including Couto, Feriduni Mwamba, Keser, HLC) has told me AA is caused by inflammation and explained how and why.
why dont you explain HOW and WHY? I dont believe it the slightest. there are strict vegans and fit guys that go bald too I doubt they have inflammation in their bodies. and there are very fat overweight guys that eat pizza and drink soda all day with perfect hair. inflammation is not the trigger in male pattern baldness. and rubbing minoxidill everyday with other alcoholic topicals on your scalp will most certainly cause inflammation in your skin which it did for me long time ago my skin turned red and i lost a sh*t load of hairs on my hairline 100 I pulled out it was caused by the minoxidill ethanol/pg. yet people grow hair back despite using ethanol/pg on their scalps everyday twice a day and eat a normal diet or even fast food diets. just SHUT THE HELL UP MUSTANG.
 

losingbattle88

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Is 100% trichosol

I have a bottle here
go ahead and change your regimen already, you dont use topical finasteride just change it already you really like to trigger people I wanna meet you IRL and fight you. you would be easy to take down cause you are a fat low T impotent man xD
 

trialAcc

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I am not currently using it. I will try CB 7.5% on my next T cycle (June-August) and see if I have better luck protecting my hair.

Dutasteride mesotherapy is extremely effective specially when used with D panthenol, IF-1, Pyridoxine and Biotin. It has an 80% percieved improvement rate vs 30% improvement if using only Dutasteride according to this publication : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596657/ (They did use a higher concentration though)

The Topical Dutasteride I use (0.1%) from FUE CLINIC also has those vitamins and growth factors. I have seen more progress since switching to it the past 6 months compared to other formulations but most importantly the sides went away. Since it doesn't have DMSO it is much safer for me. DMSO is extremely effective in penetrating the scalp and I had horrible sides with it. I also has no alcohol as a solution which is a godsend to me since my scalp get's easily irritated with anything containing alcohol

The only downside is they are a little slow with answering emails and shipments, sometimes it takes up to 4 days to get a response and I know them.
Where do you plan to get the CB? Does FUE clinic also sell it?
 

losingbattle88

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Where do you plan to get the CB? Does FUE clinic also sell it?
No way they dont sell experimental drugs only the chinese do. the fat low T man that needs T injections cause he cant get "it" up will buy from the chinese the very type of people he hates hahahahahaha funny.
 
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