Topical Dutasteride Case Assessment Thread

TanDoc

Member
My Regimen
Reaction score
16
If you are going bald with near-zero DHT and normal testosterone levels, what's your solution?
This was a rhetorical question BTW. The only answer is RU, if for some reason any and all androgens are a problem for your hair. And that's an unapproved experimental drug with little safety data.
 

Mustang

Experienced Member
My Regimen
Reaction score
337
Systemic and scalp DHT is what is linked to hair loss. T itself has MUCH weaker effect on the hair than DHT - see the picture in my next post so you can get an idea. And now we're talking a 90% DECREASE in the strong one, and only 10% increase in the weak one that has almost no effect..

If you are going bald with near-zero DHT and normal testosterone levels, what's your solution?

Take a look at people who have genetic 5-AR deficiency (next post). They produce T but no DHT. Full heads of hair, almost a female-pattern hairline

You want to reduce inflammation. I was on low dose TRT (100mg a week) with zero DHT (oral dutasteride and topical dutasteride) and my hair went to hell. That's T for you.

Solution is to use CB0301 as a Topical anti-androgen at 7.5% concentration and reduce scalp DHT to a minimum with Topical Dutasteride and potentially Dutasteride Mesotherapy as well as increase scalp blood flow with oral minoxidil, laser level cap or topical minoxidil. That's all we have right now.

Androgenic alopecia is cause by inflammation. DHT happens to be increased with inflammation along with other androgens.

"Androgen activity can be a response to inflammation, and that tension-mediated inflammation may increase DHT, AR, and TGF-β1 in Androgenetic Alopecia by inducing ROS and other pro-inflammatory biomarkers."
 

losingbattle88

Established Member
My Regimen
Reaction score
40
A little update im done with oral dutasteride.. I got one of the common side effects of dutasteride which is ejaculation disorder. My sperm just oozes out slowly now looks like it even struggles to get out of my penis. And I only use 0.5mg daily, but I wanted to bump it up to at least 2mg to block 80% of scalp dht but hell no that will only make sh*t worse. I'm pretty much 4 months on oral duta. Sonic temples is the smartest guy on this forum because he uses a small dose only once a week with no rolling and achieve results. He is causing alot less duta buildup in his system but blocks enough scalp dht for days. It's best to use a low dose once weekly or twice weekly not more and use max 0.5mm needle or nothing because I guarantee you 1mm to 1.5mm and 2mm will go systemic a sh*t load. And will definately build up in the system. oh btw, I have also experienced bad bad insomnia for 2 weeks now.
 
Last edited:

jd_uk

Senior Member
Reaction score
296
You want to reduce inflammation. I was on low dose TRT (100mg a week) with zero DHT (oral dutasteride and topical dutasteride) and my hair went to hell. That's T for you.

Solution is to use CB0301 as a Topical anti-androgen at 7.5% concentration and reduce scalp DHT to a minimum with Topical Dutasteride and potentially Dutasteride Mesotherapy as well as increase scalp blood flow with oral minoxidil, laser level cap or topical minoxidil. That's all we have right now.

Androgenic alopecia is cause by inflammation. DHT happens to be increased with inflammation along with other androgens.

"Androgen activity can be a response to inflammation, and that tension-mediated inflammation may increase DHT, AR, and TGF-β1 in Androgenetic Alopecia by inducing ROS and other pro-inflammatory biomarkers."
How much systemic effect would you say CB has beyond hair follicles?
 

lasfourmos

Member
My Regimen
Reaction score
5
I just received a 0.5% dutasteride and 1%latanoprost solution
According to your at which frequency should I use it and how much ?
 

losingbattle88

Established Member
My Regimen
Reaction score
40
How much systemic effect would you say CB has beyond hair follicles?
bro I didnt even roll my scalp when I used RU back in the days and it all went systemic. molucular weight is only 369.34 for RU and CB is 402.5. guarantee it will go systemic.
 

jd_uk

Senior Member
Reaction score
296
bro I didnt even roll my scalp when I used RU back in the days and it all went systemic. molucular weight is only 369.34 for RU and CB is 402.5. guarantee it will go systemic.
What were the negative effects? I thought CB was meant to be safer than RU somehow?
 

losingbattle88

Established Member
My Regimen
Reaction score
40
I just received a 0.5% dutasteride and 1%latanoprost solution
According to your at which frequency should I use it and how much ?
0.1% is enough your dose is ridiculous
What were the negative effects? I thought CB was meant to be safer than RU somehow?
I have only tried RU that sh*t aint clean man I had like alopecia areata after 2 months of a high dosage everyday, hair thinned out in 2 spots on my scalp never thickened back up again and I didnt have any thinning problem in those spots before the RU even, it happaned to a guy too on this very thread. but lets talk about CB, many do get side effects even from CB bro despite them saying that it breaks down in the blood. im steering away from CB and RU and just going for spironolactone+alfadratiol, spironolactone is weak yes but it works the same way as RU by attatching to the folicle receptors, and its ALOT safer, and alfadratiol is a weak estrogen that will reduce scalp testosterone. I have used spironolactone cream with alfradratiol and it killed my itch and definately reduced shedding so I know it does something. but RU increased my shedding.
 
Last edited:

lasfourmos

Member
My Regimen
Reaction score
5
0.1% is enough your dose is ridiculous

I have only tried RU that sh*t aint clean man I had like alopecia areata after 2 months of a high dosage everyday, hair thinned out in 2 spots on my scalp never thickened back up again and I didnt have any thinning problem in those spots before the RU even, it happaned to a guy too on this very thread. but lets talk about CB, many do get side effects even from CB bro despite them saying that it breaks down in the blood. im steering away from CB and RU and just going for spironolactone+alfadratiol, spironolactone is weak yes but it works the same way as RU by attatching to the folicle receptors, and its ALOT safer, and alfadratiol is a weak estrogen that will reduce scalp testosterone. I have used spironolactone cream with alfradratiol and it killed my itch and definately reduced shedding so I know it does something.
Well i will buy 0,1% then didn t knew at that time
 

jd_uk

Senior Member
Reaction score
296
0.1% is enough your dose is ridiculous

I have only tried RU that sh*t aint clean man I had like alopecia areata after 2 months of a high dosage everyday, hair thinned out in 2 spots on my scalp never thickened back up again and I didnt have any thinning problem in those spots before the RU even, it happaned to a guy too on this very thread. but lets talk about CB, many do get side effects even from CB bro despite them saying that it breaks down in the blood. im steering away from CB and RU and just going for spironolactone+alfadratiol, spironolactone is weak yes but it works the same way as RU by attatching to the folicle receptors, and its ALOT safer, and alfadratiol is a weak estrogen that will reduce scalp testosterone. I have used spironolactone cream with alfradratiol and it killed my itch and definately reduced shedding so I know it does something.
Strange that RU caused your hair to thin out. What stage is your hair loss at now? I thought spironolactone was considered strong compared to ru/cb and not great for men. Sounds like spironolactone and alfa may cause less systemic effects than RU/CB though?
 

losingbattle88

Established Member
My Regimen
Reaction score
40
Strange that RU caused your hair to thin out. What stage is your hair loss at now? I thought spironolactone was considered strong compared to ru/cb and not great for men. Sounds like spironolactone and alfa may cause less systemic effects than RU/CB though?
strange perhaps but we all react differently to experimental chemicals made in china lol. like I said a guy here on this thread had the same thinning experience as me and his hair didnt regrow either. and I have read many people on reddit complaining that RU thinned their hair too not even joking I done alot of research, even my friends hairline vanished on RU. but now to your question. spironolactone is considered weaker than RU and CB I guess but the very admin of this forum has used topical spironolactone for 18 years and has maintained his hair. the molcular mass of spironolactone is pretty small like 416 so it will definately penetrate your skin. and yes spironolactone and alfadratiol is x10 times safer than RU and CB. I had sides on RU chest pressure and a pressure feeling above my adams apple. my regimen will actually be topical dutasteride with alfadratiol/spironolactone/aceliac acid/ and possibly minoxidil.
 
Last edited:

losingbattle88

Established Member
My Regimen
Reaction score
40
so 0.1% dutasteride 2ml once per week is more than enough ?
yes bro that sounds alot safer. sonic temples only use 0.5mg once weekly with no needling even and had results. so I would definately start slow. I was dumb enough to take it orally and now I paid the price.
 

Wffd4182002

New Member
My Regimen
Reaction score
0
strange perhaps but we all react differently to experimental chemicals made in china lol. like I said a guy here on this thread had the same thinning experience as me and his hair didnt regrow either. and I have read many people on reddit complaining that RU thinned their hair too not even joking I done alot of research, even my friends hairline vanished on RU. but now to your question. spironolactone is considered weaker than RU and CB I guess but the very admin of this forum has used topical spironolactone for 18 years and has maintained his hair. the molcular mass of spironolactone is pretty small like 416 so it will definately penetrate your skin. and yes spironolactone and alfadratiol is x10 times safer than RU and CB. I had sides on RU chest pressure and a pressure feeling above my adams apple. my regimen will actually be topical dutasteride with alfadratiol/spironolactone/aceliac acid/ and possibly minoxidil.
How much spironolactone and Azaleic acid will you use? Seems like a great mix
 

lasfourmos

Member
My Regimen
Reaction score
5
yes bro that sounds alot safer. sonic temples only use 0.5mg once weekly with no needling even and had results. so I would definately start slow. I was dumb enough to take it orally and now I paid the price.
Thank i am going to test just for two week maybe the 0.5% ( i was dumb i ordered this bottle not cheap though ) and once i have the 0.1% i ll switch

or should i definitly wait for the next bottle ?
 

losingbattle88

Established Member
My Regimen
Reaction score
40
Thank i am going to test just for two week maybe the 0.5% ( i was dumb i ordered this bottle not cheap though ) and once i have the 0.1% i ll switch

or should i definitly wait for the next bottle ?
im gonna order my 0.1% dutasteride from fue clinic next time it contains growth factors and vitamins too.
 

losingbattle88

Established Member
My Regimen
Reaction score
40
How much spironolactone and Azaleic acid will you use? Seems like a great mix
im gonna use a 5% strength of aceliac acid into a bottle of alfadratiol. to make a 5% you would need to add like 2.5-3gram of it into a 60ml bottle. dont have to be precise as long as it is close to 5%. the spironolactone I will just go in blind but as long as it contains spironolactone im all good.
 

lasfourmos

Member
My Regimen
Reaction score
5
Do you happen to know the composition because it's 55 e for 60ml while farmaci andora sells 100ml with latanoprost for 40 ?
 

losingbattle88

Established Member
My Regimen
Reaction score
40
Do you happen to know the composition because it's 55 e for 60ml while farmaci andora sells 100ml with latanoprost for 40 ?
well I havent checked andora at all. but I know fue clinic use Trichosol which is safer cause it dont contain pg/alcohol that can go systemic alot more. and ofc it contains growth factors and vitamins which sounds good enough to me. 100ml for 40 sounds like a scam lol. xD
 

jd_uk

Senior Member
Reaction score
296
strange perhaps but we all react differently to experimental chemicals made in china lol. like I said a guy here on this thread had the same thinning experience as me and his hair didnt regrow either. and I have read many people on reddit complaining that RU thinned their hair too not even joking I done alot of research, even my friends hairline vanished on RU. but now to your question. spironolactone is considered weaker than RU and CB I guess but the very admin of this forum has used topical spironolactone for 18 years and has maintained his hair. the molcular mass of spironolactone is pretty small like 416 so it will definately penetrate your skin. and yes spironolactone and alfadratiol is x10 times safer than RU and CB. I had sides on RU chest pressure and a pressure feeling above my adams apple. my regimen will actually be topical dutasteride with alfadratiol/spironolactone/aceliac acid/ and possibly minoxidil.
Thanks. Maybe when CB officially comes out as breezula it might be safer?

What would you say is the best way to get some hair benefit topically without systemic activity (e.g. lowerint DHT or free test) etc?
 
Top