Systemic and scalp DHT is what is linked to hair loss. T itself has MUCH weaker effect on the hair than DHT - see the picture in my next post so you can get an idea. And now we're talking a 90% DECREASE in the strong one, and only 10% increase in the weak one that has almost no effect..
If you are going bald with near-zero DHT and normal testosterone levels, what's your solution?
Take a look at people who have genetic 5-AR deficiency (next post). They produce T but no DHT. Full heads of hair, almost a female-pattern hairline
You want to reduce inflammation. I was on low dose TRT (100mg a week) with zero DHT (oral dutasteride and topical dutasteride) and my hair went to hell. That's T for you.
Solution is to use CB0301 as a Topical anti-androgen at 7.5% concentration and reduce scalp DHT to a minimum with Topical Dutasteride and potentially Dutasteride Mesotherapy as well as increase scalp blood flow with oral minoxidil, laser level cap or topical minoxidil. That's all we have right now.
Androgenic alopecia is cause by inflammation. DHT happens to be increased with inflammation along with other androgens.
"Androgen activity can be a response to inflammation, and that tension-mediated inflammation may increase DHT, AR, and TGF-β1 in Androgenetic Alopecia by inducing ROS and other pro-inflammatory biomarkers."