Tissuse Interview, Ask Your Questions Here!

[thomps1523]

that's why i'm excited about follica. in theory follica is the best approach of all. if they can tweak the process with the right chemical signals to achieve consistent dense regrowth, then even tsuji gets irrelevant. however, we all know that follica is not there yet. their first version will probably not create high density. they have to improve it over the years and also add FGF and WNT signals as cotsarelis discovered those to be crucial some years ago. but adding these would require many more expensive trials so they are leaving them away for now, as far i understood

Here's what I'm not sure I understand... pure tech has money, and a few years ago cots said if he had what, 5 or 10 million he could cure hairloss in like 5 years. Sorry it was I believe said by cots when Desmond interviewed him a few years ago at the hair loss congress, so my memory is shaky on it. If that's the case and pure tech is funding follica, and fgf9 is the key to making this essentially a treatment that can bring you back to a full head, why is trial testing even a hold up? Do we know fgf9 hasn't been in trials between 2012 and now?

 

[pegasus2]

that's why i'm excited about follica. in theory follica is the best approach of all. if they can tweak the process with the right chemical signals to achieve consistent dense regrowth, then even tsuji gets irrelevant. however, we all know that follica is not there yet. their first version will probably not create high density. they have to improve it over the years and also add FGF and WNT signals as cotsarelis discovered those to be crucial some years ago. but adding these would require many more expensive trials so they are leaving them away for now, as far i understood

Why would they add those when wounding already induces them?

 

[baldboys]

A papilla isn't one cell.

What exactly is a papilla?

 

[pegasus2]

wounding alone already can induce hair, but only in rare cases with a lot of luck, when all the chemical stimuli in the body and the time frame is right. overall, not very efficient and not reproducable at all. so the goal is to add the right chemical stimuli during a crucial time frame of a few hours after the wounding to force the fresh multiplied cells to become hair follicle cells. figuring out the best combination of chemical signals is the whole point which cotsarelis is focused on. a few years ago there was an article where he claimed to have found out the FGF signaling to be crucial, but can't be applied without further trials.

What I meant was that wounding works in part by inducing wnt signaling and fgf production, so why would additional compounds be needed to do the same thing?

 

[thomps1523]

What I meant was that wounding works in part by inducing wnt signaling and fgf production, so why would additional compounds be needed to do the same thing?

When you get cut, and a scar comes in it still produces collegen to heal, but the collegen produced in a scar is inferior to what regular scarless skin has. Hypothetically from what I've read is a treatment including collegen could be the key to getting rid of scars. Same concept I assume...

 

[H]

What exactly is a papilla?

To my knowledge the area in which most of the blood vessels that support the follicle reside.

 

[MrV88]

Was the interview done? Estimated market release and so on?

 

[MrV88]

No the interview was never conducted. I want to know if it is still in the works. That would be fantastic

So just bla bla again?

 

[Swoop]

No the interview was never conducted. I want to know if it is still in the works. That would be fantastic

I can ask them again but I will probably get the same reply. I'll do it anyway next week.

 

[Blackber]

a dead end. their behavior is a shame.
agreeing to answer questions in an interview and then never getting back to us and letting us play the waiting game.

they have nothing, but of course keep pretending they are close, like in the email nhlpro11 mentioned once.
they are far behind tsuji, and soon they will have to admit it. they can't dance around forever, investors will see through their scheme if they are not blind.
such an unprofessionial behaviour is very unusual for german researchers or scientists in general, but i guess it happens too.

Think you're overreacting a bit...

 

[H]

a dead end. their behavior is a shame.
agreeing to answer questions in an interview and then never getting back to us and letting us play the waiting game.

they have nothing, but of course keep pretending they are close, like in the email nhlpro11 mentioned once.
they are far behind tsuji, and soon they will have to admit it. they can't dance around forever, investors will see through their scheme if they are not blind.
such an unprofessionial behaviour is very unusual for german researchers or scientists in general, but i guess it happens too.

It's kinda strange they've replied to every question I've asked them personally but haven't done the interview.

 

[Noisette]

For you @Swoop

I don't know if you have seen this one.
Article published in May 2017. But this one is in german... I will try to find in english if it does exist.. 2 pages, but only one available in preview mode.

Source: https://link.springer.com/article/10.1007/s12268-017-0800-x

Authors: Professor Rauland Lauster, Tobias Hasenberg (Tissuse), Uwe Marx , Eva-Maria Dehne

Title: " Miniaturisierte menschliche Organe auf dem Chip " May 2017

Abstract: New regulations and novel substance classes made the evaluation and authorisation process of drugs, cosmetics and chemicals not only more complicated but laborious. A microphysiological system was developed as a new foundation for substance discovery and risk assessment. Its microfluidic setup allows the combination of any 3D organ model and their interaction.

 

[Baldybald1]

If this comes out it will be much much better than tsuji technique

 

[Desmond_84]

If this comes out it will be much much better than tsuji technique

They are pretty much working on the same model, just a slightly different cocktails of supportive cells.

Lauster team believe addition of endothelial cells is key to maintaining trichogenicity whereas the Tsuji team seems to be using WNT signalling to maintain trichogenicity of cultured stem cells.

 

[mikes23]

hey @Swoop I came across an article that talks about rice university has printed capillaries. And we know how important capillaries are to getting the nutrients to the follicles. I know tissuse is isolating the dermal papilla to create neopapillae, but do you think this will be valuable? we are able to print a hair like follicle, recently we were able to print blood vessels, and now we can create capillaries. so how much more is there for a team? I wonder if they'll be able to create your follicles outside your body and grow it in a incubator until it is fully functional, then ship them out to your hair transplant doctor.
https://3dprint.com/180632/rice-baylor-3d-printed-capillaries/

 

[Joxy]

They will be on:

10th Congress on Alternatives and Animal Use in Life Sciences, 20. August 2017
Seattle, Washington, USA

So, anyone near Seattle, Washington can visit the congress and do interview with TissUse

http://wc10seattle.org/2017/home.aspx

For people that are not familiar with Berlin University. Berlin University is one of the best university in whole Germany and near countries, so I don’t believe that TissUse is joke or scam company. Germans are famous for high discipline and standards, so they are not third world country to sell scam products.

 

[MrV88]

They will be on:

10th Congress on Alternatives and Animal Use in Life Sciences, 20. August 2017
Seattle, Washington, USA

So, anyone near Seattle, Washington can visit the congress and do interview with TissUse

http://wc10seattle.org/2017/home.aspx

For people that are not familiar with Berlin University. Berlin University is one of the best university in whole Germany and near countries, so I don’t believe that TissUse is joke or scam company. Germans are famous for high discipline and standards, so they are not third world country to sell scam products.

İf you'd just know what technologies Siemens(a German brand for many sectors including health) has developed and will never be on the market, because it would change so much you wouldn't talk like that.

Germans investigate and do research, but so many things get never published, because of reasons we will never know

 

[NorwoodGuardian]

İf you'd just know what technologies Siemens(a German brand for many sectors including health) has developed and will never be on the market, because it would change so much you wouldn't talk like that.

Germans investigate and do research, but so many things get never published, because of reasons we will never know

I have very high confidence in today's technology. What always worries me is some conspiracy theory that seems to exist and deter hairloss treatment to come out, I hope my feeling wrong tho. No big advancement is this industry is because of either the conspiracy thoery or the complication of hair follicles, I really hope it's because of the latter. Anderans got canned, Histogen delay with no reasons, CB put acne before hairloss, Follica didnt commercialise for 10 years with solid science and promisimg results, is there a invisible hand behind the scene? No please!! I am very confident that within 2 to 3 years there will be a major breakthrough if no conspiracy exists.

 

[MrV88]

I have very high confidence in today's technology. What always worries me is some conspiracy theory that seems to exist and deter hairloss treatment to come out, I hope my feeling wrong tho. No big advancement is this industry is because of either the conspiracy thoery or the complication of hair follicles, I really hope it's because of the latter. Anderans got canned, Histogen delay with no reasons, CB put acne before hairloss, Follica didnt commercialise for 10 years with solid science and promisimg results, is there a invisible hand behind the scene? No please!! I am very confident that within 2 to 3 years there will be a major breakthrough if no conspiracy exists.

Hope that too, it really seems like we are going to get our stuff till 2020 and at least 3-4 alternatives that will really help.

Call them conspiracy theories or something else doesn't matter look at the Dieselgate problems. They didn't develop anything for decades and sold us the same sh*t for higher prices that is polluted as a big Chinese city. They just don't want to release something that could really work, because the cheap sh*t that they are producing will make them rich anyway and so they don't have to find something new. Think about cartels that is already enough to stop so much promising results.

 

[Joxy]

İf you'd just know what technologies Siemens(a German brand for many sectors including health) has developed and will never be on the market, because it would change so much you wouldn't talk like that.

Germans investigate and do research, but so many things get never published, because of reasons we will never know

Hm, I don’t know about that a lot, but I know that products on market made by Germans are with very big quality. Even in rich countries you have scam companies, but among Germans they are very rare. We will see. Future will tell us if they are just another science fiction story or reality.

 

[MrV88]

Hm, I don’t know about that a lot, but I know that products on market made by Germans are with very big quality. Even in rich countries you have scam companies, but among Germans they are very rare. We will see. Future will tell us if they are just another science fiction story or reality.

I live in Germany and today VW, Mercedes and BMW will be charged by the EU of forming a cartel, hindering new technologies and selling fake/scam products (in this case not clean diesel engines) for more than a decade.

Don't trust anyone too much, but I think the Japanese will do it this time

 

[Joxy]

I live in Germany and today VW, Mercedes and BMW will be charged by the EU of forming a cartel, hindering new technologies and selling fake/scam products (in this case not clean diesel engines) for more than a decade.

Don't trust anyone too much, but I think the Japanese will do it this time

If you live in Germany then maybe you can try to contact them and ask specific questions...

 

[MrV88]

If you live in Germany then maybe you can try to contact them and ask specific questions...

Speak out what you want to know and I will ask them no problem

 

[lemoncloak]

Speak out what you want to know and I will ask them no problem

Will we get the interview within this year?