The science of intermittent fasting
- Thread starter Afro_Vacancy
- Start date
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The same colour than chairs....
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- 11,938
What?
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- 11,938
Transitioning from skinnyfat to just skinny.
I just had surgery, so in principle I can start weightlifting in April. The trauma of being injured though was a bit much, so I think I might start with a period of functional training and yoga, to build nerves, balance, flexibility, coordination, etc rather than muscle.
- Reaction score
- 980
The juice's color in the photo is very similar to the colour of the chairs behind it.
OTOH the juice seems be very healthy
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Nice hopefully you can bump up that intensity in April! I have just started to train more seriously. I severely reduced my alcohol intake and I'm taking my diet more seriously now. Really helps, feeling stronger than ever.
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- 11,938
What are your goals?
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- 1,332
Physique wise I want to go to where I have never been before. I basically want to reach close to my genetic potential. I don't want to get ripped but just "lean".
In the gym I always set short term goals to increase the total poundage.
You?
- Reaction score
- 11,938
To get as cut as possible prior to mid-April, when I can start lifting again. Might do two days a week of fasting until then.
I'd like to see a six pack on myself, and it, a chiseled jaw and cheekbones. It's a good base from where to start bulking.
- Reaction score
- 11,938
February 7th, 2017, 183.0 lbs, 83.0 Kg
February 8th, 2017, 180.4 lbs. 81.8 Kg
February 25th, 2017, 176.8 lbs, 80.2 Kg*
February 26th, 2017, 175.0 lbs, 79.4 Kg*
March 2nd, 2017, 175.0 lbs, 79.4 Kg
I did a one-day "fast" yesterday though I had ~150 calories around dinner: 1 cup of soy milk, one cup of kombucha. I had a cold so I was freezing all day, it sucked. My mouth tastes like metal right now, an indicator of ketosis but somehow not one I've experienced often.
February 8th, 2017, 180.4 lbs. 81.8 Kg
February 25th, 2017, 176.8 lbs, 80.2 Kg*
February 26th, 2017, 175.0 lbs, 79.4 Kg*
March 2nd, 2017, 175.0 lbs, 79.4 Kg
I did a one-day "fast" yesterday though I had ~150 calories around dinner: 1 cup of soy milk, one cup of kombucha. I had a cold so I was freezing all day, it sucked. My mouth tastes like metal right now, an indicator of ketosis but somehow not one I've experienced often.
If you do a three day water fast then by the third day youre in ketosis. If you continue a diet with less than 20grams of net carbs a day for your body will stay in ketosis. If you do that for two weeks or a month its a great fat burner if weightloss is the ultimate goal. Just break the fast lightly. Its hard to not eat carbs thou. If a bowl of broccoli has 20 carbs and 15 carbs from fiber then thats only 5 net carbs so veggies are good for a keto diet.
- Reaction score
- 11,938
http://news.yale.edu/2015/02/16/ant...ing-and-fasting-revealed#.WLiuA6tj2nk.twitter
Anti-inflammatory mechanism of dieting and fasting revealed
By Karen N. Peart
February 16, 2015
Researchers at Yale School of Medicine have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer’s disease.
In their study, published in the Feb. 16 online issue of Nature Medicine, the researchers described how the compound β-hydroxybutyrate (BHB) directly inhibits NLRP3, which is part of a complex set of proteins called the inflammasome. The inflammasome drives the inflammatory response in several disorders including autoimmune diseases, type 2 diabetes, Alzheimer’s disease, atherosclerosis, and autoinflammatory disorders.
“These findings are important because endogenous metabolites like BHB that block the NLRP3 inflammasome could be relevant against many inflammatory diseases, including those where there are mutations in the NLRP3 genes,” said Vishwa Deep Dixit, professor in the Section of Comparative Medicine at Yale School of Medicine.
BHB is a metabolite produced by the body in response to fasting, high-intensity exercise, caloric restriction, or consumption of the low-carbohydrate ketogenic diet. Dixit said it is well known that fasting and calorie restriction reduces inflammation in the body, but it was unclear how immune cells adapt to reduced availability of glucose and if they can respond to metabolites produced from fat oxidation.
Working with mice and human immune cells, Dixit and colleagues focused on how macrophages — specialized immune cells that produce inflammation — respond when exposed to ketone bodies and whether that impacts the inflammasone complex.
The team introduced BHB to mouse models of inflammatory diseases caused by NLP3. They found that this reduced inflammation, and that inflammation was also reduced when the mice were given a ketogenic diet, which elevates the levels of BHB in the bloodstream.
“Our results suggest that the endogenous metabolites like BHB that are produced during low-carb dieting, fasting, or high-intensity exercise can lower the NLRP3 inflammasome,” said Dixit.
Other authors on the study include Yun-Hee Youm, Kim Y. Nguyen, Ryan W Grant, Emily L. Goldberg, Monica Bodogai, Dongin Kim, Dominic D’Agostino, Noah Planavsky, Christopher Lupfer, Thirumala D Kanneganti, Seokwon Kang, Tamas L. Horvath, Tarek M. Fahmy, Peter A. Crawford, Arya Biragyn, and Emad Alnemri.
The research was funded in part by National Institutes of Health grants AI105097, AGO43608, AG031797, and DK090556.
Citation: Nature Medicine DOI: 10.1038/nm.3804
(Image via Shutterstock)
Anti-inflammatory mechanism of dieting and fasting revealed
By Karen N. Peart
February 16, 2015
Researchers at Yale School of Medicine have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer’s disease.
In their study, published in the Feb. 16 online issue of Nature Medicine, the researchers described how the compound β-hydroxybutyrate (BHB) directly inhibits NLRP3, which is part of a complex set of proteins called the inflammasome. The inflammasome drives the inflammatory response in several disorders including autoimmune diseases, type 2 diabetes, Alzheimer’s disease, atherosclerosis, and autoinflammatory disorders.
“These findings are important because endogenous metabolites like BHB that block the NLRP3 inflammasome could be relevant against many inflammatory diseases, including those where there are mutations in the NLRP3 genes,” said Vishwa Deep Dixit, professor in the Section of Comparative Medicine at Yale School of Medicine.
BHB is a metabolite produced by the body in response to fasting, high-intensity exercise, caloric restriction, or consumption of the low-carbohydrate ketogenic diet. Dixit said it is well known that fasting and calorie restriction reduces inflammation in the body, but it was unclear how immune cells adapt to reduced availability of glucose and if they can respond to metabolites produced from fat oxidation.
Working with mice and human immune cells, Dixit and colleagues focused on how macrophages — specialized immune cells that produce inflammation — respond when exposed to ketone bodies and whether that impacts the inflammasone complex.
The team introduced BHB to mouse models of inflammatory diseases caused by NLP3. They found that this reduced inflammation, and that inflammation was also reduced when the mice were given a ketogenic diet, which elevates the levels of BHB in the bloodstream.
“Our results suggest that the endogenous metabolites like BHB that are produced during low-carb dieting, fasting, or high-intensity exercise can lower the NLRP3 inflammasome,” said Dixit.
Other authors on the study include Yun-Hee Youm, Kim Y. Nguyen, Ryan W Grant, Emily L. Goldberg, Monica Bodogai, Dongin Kim, Dominic D’Agostino, Noah Planavsky, Christopher Lupfer, Thirumala D Kanneganti, Seokwon Kang, Tamas L. Horvath, Tarek M. Fahmy, Peter A. Crawford, Arya Biragyn, and Emad Alnemri.
The research was funded in part by National Institutes of Health grants AI105097, AGO43608, AG031797, and DK090556.
Citation: Nature Medicine DOI: 10.1038/nm.3804
(Image via Shutterstock)
- Reaction score
- 11,938
February 7th, 2017, 183.0 lbs, 83.0 Kg
February 8th, 2017, 180.4 lbs. 81.8 Kg
February 25th, 2017, 176.8 lbs, 80.2 Kg*
February 26th, 2017, 175.0 lbs, 79.4 Kg*
March 2nd, 2017, 175.0 lbs, 79.4 Kg
March 4th, 2017, 175.2 lbs, 79.5 Kg
February 8th, 2017, 180.4 lbs. 81.8 Kg
February 25th, 2017, 176.8 lbs, 80.2 Kg*
February 26th, 2017, 175.0 lbs, 79.4 Kg*
March 2nd, 2017, 175.0 lbs, 79.4 Kg
March 4th, 2017, 175.2 lbs, 79.5 Kg
- Reaction score
- 11,938
February 7th, 2017, 183.0 lbs, 83.0 Kg
February 8th, 2017, 180.4 lbs. 81.8 Kg
February 25th, 2017, 176.8 lbs, 80.2 Kg*
February 26th, 2017, 175.0 lbs, 79.4 Kg*
March 2nd, 2017, 175.0 lbs, 79.4 Kg
March 4th, 2017, 175.2 lbs, 79.5 Kg
March 6th, 2017, 174.4 lbs, 79.1 Kg*
I did eat around ~500 calories. First I had some of those echinacea/honey candies throughout the day to help with a cough. Second, around 800pm I had a glass of warm milk and 1.5 slices of banana bread. Worst foods to eat on a fast lol but whatever.
February 8th, 2017, 180.4 lbs. 81.8 Kg
February 25th, 2017, 176.8 lbs, 80.2 Kg*
February 26th, 2017, 175.0 lbs, 79.4 Kg*
March 2nd, 2017, 175.0 lbs, 79.4 Kg
March 4th, 2017, 175.2 lbs, 79.5 Kg
March 6th, 2017, 174.4 lbs, 79.1 Kg*
I did eat around ~500 calories. First I had some of those echinacea/honey candies throughout the day to help with a cough. Second, around 800pm I had a glass of warm milk and 1.5 slices of banana bread. Worst foods to eat on a fast lol but whatever.
- Reaction score
- 11,938
February 7th, 2017, 183.0 lbs, 83.0 Kg
February 8th, 2017, 180.4 lbs. 81.8 Kg
February 25th, 2017, 176.8 lbs, 80.2 Kg*
February 26th, 2017, 175.0 lbs, 79.4 Kg*
March 2nd, 2017, 175.0 lbs, 79.4 Kg
March 4th, 2017, 175.2 lbs, 79.5 Kg
March 6th, 2017, 174.4 lbs, 79.1 Kg*
March 8th, 2017, 174.4 lbs, 79.1 Kg
The only thing I ate yesterday was cough syrup (pretty sweet), other medicines, and a small square of pineapple as a sample from the supermarket.
February 8th, 2017, 180.4 lbs. 81.8 Kg
February 25th, 2017, 176.8 lbs, 80.2 Kg*
February 26th, 2017, 175.0 lbs, 79.4 Kg*
March 2nd, 2017, 175.0 lbs, 79.4 Kg
March 4th, 2017, 175.2 lbs, 79.5 Kg
March 6th, 2017, 174.4 lbs, 79.1 Kg*
March 8th, 2017, 174.4 lbs, 79.1 Kg
The only thing I ate yesterday was cough syrup (pretty sweet), other medicines, and a small square of pineapple as a sample from the supermarket.
- Reaction score
- 11,938
February 7th, 2017, 183.0 lbs, 83.0 Kg
February 8th, 2017, 180.4 lbs. 81.8 Kg
February 25th, 2017, 176.8 lbs, 80.2 Kg*
February 26th, 2017, 175.0 lbs, 79.4 Kg*
March 2nd, 2017, 175.0 lbs, 79.4 Kg
March 4th, 2017, 175.2 lbs, 79.5 Kg
March 6th, 2017, 174.4 lbs, 79.1 Kg*
March 8th, 2017, 174.4 lbs, 79.1 Kg
March 10th, 2017, 174.4 lbs, 79.1 Kg*
The only thing I ate yesterday was cough syrup (pretty sweet), other medicines, a 2-egg omelette at dinner with cheese, nuts, and spicy vegetables/olives. Approximately ~500 calories.
Weight is stalling during this otherwise good run of alternate-day fasting, which suggests that I'm overdue for a whoosh.
February 8th, 2017, 180.4 lbs. 81.8 Kg
February 25th, 2017, 176.8 lbs, 80.2 Kg*
February 26th, 2017, 175.0 lbs, 79.4 Kg*
March 2nd, 2017, 175.0 lbs, 79.4 Kg
March 4th, 2017, 175.2 lbs, 79.5 Kg
March 6th, 2017, 174.4 lbs, 79.1 Kg*
March 8th, 2017, 174.4 lbs, 79.1 Kg
March 10th, 2017, 174.4 lbs, 79.1 Kg*
The only thing I ate yesterday was cough syrup (pretty sweet), other medicines, a 2-egg omelette at dinner with cheese, nuts, and spicy vegetables/olives. Approximately ~500 calories.
Weight is stalling during this otherwise good run of alternate-day fasting, which suggests that I'm overdue for a whoosh.
- Reaction score
- 11,938
A friend in medical school asked me for this, it's a bibliography of fasting studies.
General and Classics:
Some references taken from here:
https://authoritynutrition.com/10-health-benefits-of-intermittent-fasting/
Jason Fung's fasting series, Part II (linked here is colloquiual), parts 3 and 4 are very technical, and it goes on
https://intensivedietarymanagement.com/fasting-physiology-part-ii/
Article on a 20-day fast that made the cover of Harper's a while back:
http://media.wix.com/ugd/03997d_422ba2e2c279e899b8d1c3de71f1b1e7.pdf
Features of a successful therapeutic fast of 382 days' duration
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2495396/
Medically supervised water-only fasting in the treatment of hypertension.
https://www.ncbi.nlm.nih.gov/pubmed/11416824
Medically supervised water-only fasting in the treatment of borderline hypertension.
https://www.ncbi.nlm.nih.gov/pubmed/12470446
Fasting: the history, pathophysiology and complications.
https://www.ncbi.nlm.nih.gov/pubmed/6758355
Miscellany on Human Growth Hormone, Autophagy, Norepinephrine, Etc.
A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity.
https://www.ncbi.nlm.nih.gov/pubmed/27569118
Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC329619/
Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men.
https://www.ncbi.nlm.nih.gov/pubmed/1548337
Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.
https://www.ncbi.nlm.nih.gov/pubmed/3127426
Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine.
https://www.ncbi.nlm.nih.gov/pubmed/10837292
Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism.
https://www.ncbi.nlm.nih.gov/pubmed/15640462
Metabolic regulation of Sirtuins upon fasting and the implication for cancer.
https://www.ncbi.nlm.nih.gov/pubmed/24048020
Caloric restriction and intermittent fasting: Two potential diets for successful brain aging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2622429/
Short-term fasting induces profound neuronal autophagy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/
Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation.
https://www.ncbi.nlm.nih.gov/pubmed/21106691
Prolonged Fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102383/
Fasting and Weighlifting
Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males
http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1044-0
Time-restricted feeding in young men performing resistance training: A randomized controlled trial.
https://www.ncbi.nlm.nih.gov/pubmed/27550719
Krista Varady's Research on Alternate-Day Fasting
Dietary and physical activity adaptations to alternate day modified fasting: implications for optimal weight loss.
https://www.ncbi.nlm.nih.gov/pubmed/20815899
Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults.
https://www.ncbi.nlm.nih.gov/pubmed/19793855
Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial.
https://www.ncbi.nlm.nih.gov/pubmed/24215592
Improvements in LDL particle size and distribution by short-term alternate day modified fasting in obese adults.
https://www.ncbi.nlm.nih.gov/pubmed/20880415
Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women.
https://www.ncbi.nlm.nih.gov/pubmed/23171320
Safety of alternate day fasting and effect on disordered eating behaviors.
https://www.ncbi.nlm.nih.gov/pubmed/25943396
Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans.
https://www.ncbi.nlm.nih.gov/pubmed/23612508
Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans.
https://www.ncbi.nlm.nih.gov/pubmed/23408502
Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet.
https://www.ncbi.nlm.nih.gov/pubmed/22889512
Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations.
https://www.ncbi.nlm.nih.gov/pubmed/20300080
Benefit of a low-fat over high-fat diet on vascular health during alternate day fasting.
https://www.ncbi.nlm.nih.gov/pubmed/23712283
Meal timing during alternate day fasting: Impact on body weight and cardiovascular disease risk in obese adults.
https://www.ncbi.nlm.nih.gov/pubmed/25251676
Effect of exercising while fasting on eating behaviors and food intake.
https://www.ncbi.nlm.nih.gov/pubmed/24176020
Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting.
https://www.ncbi.nlm.nih.gov/pubmed/27062219
Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations.
https://www.ncbi.nlm.nih.gov/pubmed/23113919
Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles.
https://www.ncbi.nlm.nih.gov/pubmed/25557754
Modified alternate-day fasting and cardioprotection: relation to adipose tissue dynamics and dietary fat intake.
https://www.ncbi.nlm.nih.gov/pubmed/19375762
Determinants of weight loss success with alternate day fasting.
https://www.ncbi.nlm.nih.gov/pubmed/26385599
Alternate-day fasting reduces global cell proliferation rates independently of dietary fat content in mice.
https://www.ncbi.nlm.nih.gov/pubmed/19084375
Impact of intermittent fasting on glucose homeostasis.
https://www.ncbi.nlm.nih.gov/pubmed/27137896
Alternate-day fasting and chronic disease prevention: a review of human and animal trials.
https://www.ncbi.nlm.nih.gov/pubmed/17616757
Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice.
https://www.ncbi.nlm.nih.gov/pubmed/17607017
Dose effects of modified alternate-day fasting regimens on in vivo cell proliferation and plasma insulin-like growth factor-1 in mice.
https://www.ncbi.nlm.nih.gov/pubmed/17495119
Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction.
https://www.ncbi.nlm.nih.gov/pubmed/19195863
Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice.
https://www.ncbi.nlm.nih.gov/pubmed/18184721
Effects of different degrees of insulin resistance on endothelial function in obese adults undergoing alternate day fasting.
https://www.ncbi.nlm.nih.gov/pubmed/28035343
Valter Longo's research, mostly focused on the fast-mimicking diet and applications to cancer treatment, the immune system, and life extension
Here's a TEDx talk by Valter Longo
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes.
https://www.ncbi.nlm.nih.gov/pubmed/28235195
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.
https://www.ncbi.nlm.nih.gov/pubmed/28202779
Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence.
https://www.ncbi.nlm.nih.gov/pubmed/28137612
Impact of intermittent fasting on health and disease processes.
https://www.ncbi.nlm.nih.gov/pubmed/27810402
Fasting and Caloric Restriction in Cancer Prevention and Treatment.
https://www.ncbi.nlm.nih.gov/pubmed/27557543
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.
https://www.ncbi.nlm.nih.gov/pubmed/27411588
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan.
https://www.ncbi.nlm.nih.gov/pubmed/27304506
Safety and feasibility of fasting in combination with platinum-based chemotherapy.
https://www.ncbi.nlm.nih.gov/pubmed/27282289
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.
https://www.ncbi.nlm.nih.gov/pubmed/27239035
Fasting plus tyrosine kinase inhibitors in cancer.
https://www.ncbi.nlm.nih.gov/pubmed/26645151
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.
https://www.ncbi.nlm.nih.gov/pubmed/26094889
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition.
https://www.ncbi.nlm.nih.gov/pubmed/25909220
Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.
https://www.ncbi.nlm.nih.gov/pubmed/25909219
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.
https://www.ncbi.nlm.nih.gov/pubmed/24905167
Fasting: molecular mechanisms and clinical applications.
https://www.ncbi.nlm.nih.gov/pubmed/24440038
Fasting enhances the response of glioma to chemo- and radiotherapy.
https://www.ncbi.nlm.nih.gov/pubmed/22984531
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.
https://www.ncbi.nlm.nih.gov/pubmed/22323820
Fasting and differential chemotherapy protection in patients.
https://www.ncbi.nlm.nih.gov/pubmed/21088487
Fasting and cancer treatment in humans: A case series report.
https://www.ncbi.nlm.nih.gov/pubmed/20157582
Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index.
https://www.ncbi.nlm.nih.gov/pubmed/20145127
Fasting and the Brain
Tedx talk by Mark Mattson, one of the dominant researchers here:
Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment.
https://www.ncbi.nlm.nih.gov/pubmed/24886300
Intermittent fasting attenuates inflammasome activity in ischemic stroke.
https://www.ncbi.nlm.nih.gov/pubmed/24805069
Chronic Intermittent Fasting Improves Cognitive Functions and Brain Structures in Mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670843/
Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats.
https://www.ncbi.nlm.nih.gov/pubmed/11220789
Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice
http://onlinelibrary.wiley.com/doi/10.1046/j.0022-3042.2001.00747.x/abstract
Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats.
https://www.ncbi.nlm.nih.gov/pubmed/11220789
Energy intake, meal frequency, and health: a neurobiological perspective.
https://www.ncbi.nlm.nih.gov/pubmed/16011467
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151440/
The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022308/
Age and Energy Intake Interact to Modify Cell Stress Pathways and Stroke Outcome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844782/
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease.
https://www.ncbi.nlm.nih.gov/pubmed/17306982
Reversal of cognitive decline: A novel therapeutic program
http://www.aging-us.com/article/100690
Caloric restriction and intermittent fasting: Two potential diets for successful brain aging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2622429/
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease.
https://www.ncbi.nlm.nih.gov/pubmed/10398297
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease.
https://www.ncbi.nlm.nih.gov/pubmed/23276384
Intermittent fasting: A “new” historical strategy for controlling seizures?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740951/
Bonus: Discussion of Coffee, Diabetes, and Weight Control
http://www.bodyrecomposition.com/re...etes-and-weight-control-research-review.html/
General and Classics:
Some references taken from here:
https://authoritynutrition.com/10-health-benefits-of-intermittent-fasting/
Jason Fung's fasting series, Part II (linked here is colloquiual), parts 3 and 4 are very technical, and it goes on
https://intensivedietarymanagement.com/fasting-physiology-part-ii/
Article on a 20-day fast that made the cover of Harper's a while back:
http://media.wix.com/ugd/03997d_422ba2e2c279e899b8d1c3de71f1b1e7.pdf
Features of a successful therapeutic fast of 382 days' duration
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2495396/
Medically supervised water-only fasting in the treatment of hypertension.
https://www.ncbi.nlm.nih.gov/pubmed/11416824
Medically supervised water-only fasting in the treatment of borderline hypertension.
https://www.ncbi.nlm.nih.gov/pubmed/12470446
Fasting: the history, pathophysiology and complications.
https://www.ncbi.nlm.nih.gov/pubmed/6758355
Miscellany on Human Growth Hormone, Autophagy, Norepinephrine, Etc.
A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity.
https://www.ncbi.nlm.nih.gov/pubmed/27569118
Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC329619/
Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men.
https://www.ncbi.nlm.nih.gov/pubmed/1548337
Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.
https://www.ncbi.nlm.nih.gov/pubmed/3127426
Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine.
https://www.ncbi.nlm.nih.gov/pubmed/10837292
Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism.
https://www.ncbi.nlm.nih.gov/pubmed/15640462
Metabolic regulation of Sirtuins upon fasting and the implication for cancer.
https://www.ncbi.nlm.nih.gov/pubmed/24048020
Caloric restriction and intermittent fasting: Two potential diets for successful brain aging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2622429/
Short-term fasting induces profound neuronal autophagy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/
Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation.
https://www.ncbi.nlm.nih.gov/pubmed/21106691
Prolonged Fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102383/
Fasting and Weighlifting
Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males
http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1044-0
Time-restricted feeding in young men performing resistance training: A randomized controlled trial.
https://www.ncbi.nlm.nih.gov/pubmed/27550719
Krista Varady's Research on Alternate-Day Fasting
Dietary and physical activity adaptations to alternate day modified fasting: implications for optimal weight loss.
https://www.ncbi.nlm.nih.gov/pubmed/20815899
Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults.
https://www.ncbi.nlm.nih.gov/pubmed/19793855
Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial.
https://www.ncbi.nlm.nih.gov/pubmed/24215592
Improvements in LDL particle size and distribution by short-term alternate day modified fasting in obese adults.
https://www.ncbi.nlm.nih.gov/pubmed/20880415
Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women.
https://www.ncbi.nlm.nih.gov/pubmed/23171320
Safety of alternate day fasting and effect on disordered eating behaviors.
https://www.ncbi.nlm.nih.gov/pubmed/25943396
Alternate day fasting increases LDL particle size independently of dietary fat content in obese humans.
https://www.ncbi.nlm.nih.gov/pubmed/23612508
Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans.
https://www.ncbi.nlm.nih.gov/pubmed/23408502
Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet.
https://www.ncbi.nlm.nih.gov/pubmed/22889512
Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations.
https://www.ncbi.nlm.nih.gov/pubmed/20300080
Benefit of a low-fat over high-fat diet on vascular health during alternate day fasting.
https://www.ncbi.nlm.nih.gov/pubmed/23712283
Meal timing during alternate day fasting: Impact on body weight and cardiovascular disease risk in obese adults.
https://www.ncbi.nlm.nih.gov/pubmed/25251676
Effect of exercising while fasting on eating behaviors and food intake.
https://www.ncbi.nlm.nih.gov/pubmed/24176020
Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting.
https://www.ncbi.nlm.nih.gov/pubmed/27062219
Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations.
https://www.ncbi.nlm.nih.gov/pubmed/23113919
Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles.
https://www.ncbi.nlm.nih.gov/pubmed/25557754
Modified alternate-day fasting and cardioprotection: relation to adipose tissue dynamics and dietary fat intake.
https://www.ncbi.nlm.nih.gov/pubmed/19375762
Determinants of weight loss success with alternate day fasting.
https://www.ncbi.nlm.nih.gov/pubmed/26385599
Alternate-day fasting reduces global cell proliferation rates independently of dietary fat content in mice.
https://www.ncbi.nlm.nih.gov/pubmed/19084375
Impact of intermittent fasting on glucose homeostasis.
https://www.ncbi.nlm.nih.gov/pubmed/27137896
Alternate-day fasting and chronic disease prevention: a review of human and animal trials.
https://www.ncbi.nlm.nih.gov/pubmed/17616757
Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice.
https://www.ncbi.nlm.nih.gov/pubmed/17607017
Dose effects of modified alternate-day fasting regimens on in vivo cell proliferation and plasma insulin-like growth factor-1 in mice.
https://www.ncbi.nlm.nih.gov/pubmed/17495119
Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction.
https://www.ncbi.nlm.nih.gov/pubmed/19195863
Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice.
https://www.ncbi.nlm.nih.gov/pubmed/18184721
Effects of different degrees of insulin resistance on endothelial function in obese adults undergoing alternate day fasting.
https://www.ncbi.nlm.nih.gov/pubmed/28035343
Valter Longo's research, mostly focused on the fast-mimicking diet and applications to cancer treatment, the immune system, and life extension
Here's a TEDx talk by Valter Longo
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes.
https://www.ncbi.nlm.nih.gov/pubmed/28235195
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.
https://www.ncbi.nlm.nih.gov/pubmed/28202779
Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence.
https://www.ncbi.nlm.nih.gov/pubmed/28137612
Impact of intermittent fasting on health and disease processes.
https://www.ncbi.nlm.nih.gov/pubmed/27810402
Fasting and Caloric Restriction in Cancer Prevention and Treatment.
https://www.ncbi.nlm.nih.gov/pubmed/27557543
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.
https://www.ncbi.nlm.nih.gov/pubmed/27411588
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan.
https://www.ncbi.nlm.nih.gov/pubmed/27304506
Safety and feasibility of fasting in combination with platinum-based chemotherapy.
https://www.ncbi.nlm.nih.gov/pubmed/27282289
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.
https://www.ncbi.nlm.nih.gov/pubmed/27239035
Fasting plus tyrosine kinase inhibitors in cancer.
https://www.ncbi.nlm.nih.gov/pubmed/26645151
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.
https://www.ncbi.nlm.nih.gov/pubmed/26094889
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition.
https://www.ncbi.nlm.nih.gov/pubmed/25909220
Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.
https://www.ncbi.nlm.nih.gov/pubmed/25909219
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.
https://www.ncbi.nlm.nih.gov/pubmed/24905167
Fasting: molecular mechanisms and clinical applications.
https://www.ncbi.nlm.nih.gov/pubmed/24440038
Fasting enhances the response of glioma to chemo- and radiotherapy.
https://www.ncbi.nlm.nih.gov/pubmed/22984531
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.
https://www.ncbi.nlm.nih.gov/pubmed/22323820
Fasting and differential chemotherapy protection in patients.
https://www.ncbi.nlm.nih.gov/pubmed/21088487
Fasting and cancer treatment in humans: A case series report.
https://www.ncbi.nlm.nih.gov/pubmed/20157582
Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index.
https://www.ncbi.nlm.nih.gov/pubmed/20145127
Fasting and the Brain
Tedx talk by Mark Mattson, one of the dominant researchers here:
Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment.
https://www.ncbi.nlm.nih.gov/pubmed/24886300
Intermittent fasting attenuates inflammasome activity in ischemic stroke.
https://www.ncbi.nlm.nih.gov/pubmed/24805069
Chronic Intermittent Fasting Improves Cognitive Functions and Brain Structures in Mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670843/
Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats.
https://www.ncbi.nlm.nih.gov/pubmed/11220789
Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice
http://onlinelibrary.wiley.com/doi/10.1046/j.0022-3042.2001.00747.x/abstract
Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats.
https://www.ncbi.nlm.nih.gov/pubmed/11220789
Energy intake, meal frequency, and health: a neurobiological perspective.
https://www.ncbi.nlm.nih.gov/pubmed/16011467
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151440/
The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022308/
Age and Energy Intake Interact to Modify Cell Stress Pathways and Stroke Outcome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844782/
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease.
https://www.ncbi.nlm.nih.gov/pubmed/17306982
Reversal of cognitive decline: A novel therapeutic program
http://www.aging-us.com/article/100690
Caloric restriction and intermittent fasting: Two potential diets for successful brain aging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2622429/
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease.
https://www.ncbi.nlm.nih.gov/pubmed/10398297
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease.
https://www.ncbi.nlm.nih.gov/pubmed/23276384
Intermittent fasting: A “new” historical strategy for controlling seizures?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740951/
Bonus: Discussion of Coffee, Diabetes, and Weight Control
http://www.bodyrecomposition.com/re...etes-and-weight-control-research-review.html/
