Surprising Update On Hanson & Wong. Could Be Nice! | Page 11 | HairLossTalk Forums

Surprising Update On Hanson & Wong. Could Be Nice!

Discussion in 'New Research, Studies, and Technologies' started by Pavi, Nov 7, 2017.

  1. Dolph

    Dolph Established Member

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    I have some (formulated to 1%) on the way. Given my reaction to oral finasteride (bad), I'll know if there are sides from this after a week. I'll be getting a full hormonal panel before and during. It will be a few weeks before I see my Doctor again for the tests, but I'll update here.
     
  2. MedicinallyCompetent

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    I address this by doing minoxidil in the morning after a shower and the finasteride at night.

    I'm now 2.5 weeks of using 1% liposomal H&W every other day. Since my last update I'm pretty sure the erection quality thing was psychological as they're now totally normal. I have seen a small increase in watery ejaculate. I'm not going to do pictures/bloodwork. To be honest I don't have the time or the effort in me to do it. At this point 1% every other day is totally sustainable with no sides. At this point on oral finasteride I started to reduce my frequency because the sexual sides were so bad. I'm going to finish the month protocol of every other day and if the sides don't get worse then I'll bump it to every day.

    The biggest problem is 1mL per application covers very little surface area. I'm going to call the pharmacy for the next batch to see if I can get the same equivalent of medicinal ingredient but twice the vehicle to cover more area of my head. If you're a diffuse thinner like me I think you'll have the same problem.
     
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  3. FutureSaitama

    FutureSaitama Experienced Member My Regimen

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    To solve the problem, you need to buzz your hair really short.
     
  4. vegetassj

    vegetassj Established Member

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    Mhm makes sense, maybe I try to switch minoxidil or finasteride to the morning. Thing is I can barely go out with this shit on my hair
     
  5. Calchas

    Calchas Established Member My Regimen

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    Finasteride doesn't work topically,period.
    Whatever results you get is from systemic absorption.
    Fina inhibits types 2 and 3 of 5ar.
    Scalp after puberty expresses only type 1 5ar, which can be blocked by duta.
     
  6. ALightInTheDark

    ALightInTheDark Established Member My Regimen

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    Oh I guess you tested it for 6months + and can report your resul..Ah. No. I thought so :)
     
  7. Calchas

    Calchas Established Member My Regimen

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    It's just science..
     
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  8. ALightInTheDark

    ALightInTheDark Established Member My Regimen

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    Science isn't exact and absolute truth. Everyone is different.
     
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  9. InBeforeTheCure

    InBeforeTheCure Established Member My Regimen

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    False.
     
  10. Calchas

    Calchas Established Member My Regimen

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    The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
    Faris Azzouni, Alejandro Godoy, Yun Li, and James Mohler

    9.1.2. Newborn-Onset of Puberty

    In newborns, 5α-R1 is expressed at the protein level in the liver, skin, scalp [13] and prostate [55]. 5α-R2 is expressed in prostate, seminal vesicles, epididymis, liver, and to lesser extent in scalp and skin [13]. Hepatic expression of 5α-R1 and 2 is present at the protein level (immunoblotting) throughout postnatal life. At approximately 1.5 years, the expression of both proteins is not detected in the skin and scalp until the onset of puberty. At puberty, only 5α-R1 is reexpressed in the skin and scalp and persists thereafter until 81 years. In the prostate gland, Lunacek et al. reported that both 5α-R1 and 5α-R2 were detectable at the protein level using IHC until approximately 1 year of age. After that, they were detectable at the mRNA level (RT-PCR) until 6 years of age. Thigpen et al. only detected 5α-R2 at the protein level using immunoblotting in prostatic tissue from a 7-year-old male. Since the methods used by this group did not detect 5α-R1 protein in the newborn, juvenile, or adult prostatic tissues, and since other groups detected 5α-R1 at the protein level in fetal and adult benign prostatic tissue, 5α-R1 and 5α-R2 appear to be expressed in the prostate in male fetuses and throughout postnatal life.
     
  11. InBeforeTheCure

    InBeforeTheCure Established Member My Regimen

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    The paper I cited explained this discrepancy. Those other studies sampled whole scalp skin and, since 5ar Type I is expressed throughout the hair follicle, the Type I signal dominates. Type II is expressed only in the mesenchymal part of the follicle (dermal papilla and dermal sheath). They examined that part of the follicle in isolation and detected Type II. Still, there are some conflicting results between studies for some reason.

     
  12. Calchas

    Calchas Established Member My Regimen

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    Yeah,the confusing part of the study you cited is that it doesn't find any difference in the expression of androgen receptors and 5ar between balding and non-balding follicles,which contradicts other studies that showed and increased expression of bot AR and 5ar in balding scalp.
     
  13. cretin

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    2018, still trying to market an underwhelming 30 year old drug. ;)
     
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  14. tjnpdx

    tjnpdx Banned

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    New guy gets it. ;)
     
  15. UberBaldaten

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    So we should focus our efforts on topical dutasteride ?
     
  16. cretin

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    you focus on something that is not baloney 30 year old no efficacy

    30 years old = exhausted potential. What you think guy log on tomorrow and report NW7 to NW2 with topical dutasteride? I have a 12 inch cock and i fuck gal gadot do you believe me
     
  17. ALightInTheDark

    ALightInTheDark Established Member My Regimen

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    Polichem Duta ;)
     
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  18. vegetassj

    vegetassj Established Member

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    It doesnt give me sides in comparisson to oral finasteride.

    I dont care how it works, if it works atleast a bit I can live with it. Need to do a hair transplant anyway.
    And atleast this does not come from alibaba or elsewhere and is produced by an european pharmaccia.
     
  19. cretin

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    my guy listen you have no idea how to compares until you use for at least 1 year

    finasteride guy 3 months "ohhhh its realy good i beat dick 5 time daily"

    finasteride guy 1 year thinking about becoming women full time

    always guys like this finasteride work for them for a little while and then side effects start

    no rational to believe works other than normal finasteride Method OF action! Drug is metabolized in blood and liver CYP 3A4 all the same! Wong et al must hypothesis and test new model if they want cucks to believe otherwise!
     
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  20. vegetassj

    vegetassj Established Member

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    Ur correct. I will report back 3-6 month.
     

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