SM04554 Phase 2 results

distracted · Mar 4, 2016

occulus said:
So we're certain it would cost $1000 to attend? If not, I will definitely go - I'm close and it would be easy for me.

Registration is closed.

throwaway592845 · Mar 4, 2016

Short question from someone who has not been in the game for long: Does SM04554 act downstream of the DHT-induced problem? Or has it a completely new method of action (meaning that in case it is effective it could be used together with finasteride for better results) ?

bbbeeeppp2 · Mar 4, 2016

throwaway592845 said:
Short question from someone who has not been in the game for long: Does SM04554 act downstream of the DHT-induced problem? Or has it a completely new method of action (meaning that in case it is effective it could be used together with finasteride for better results) ?

It uses the wnt signaling pathway. A key pathway involved in hair follicle neogenesis. It's completely different to Fins mechanism of action, it's basically signalling your hair follicles to grow and develop instead of inhibiting the signal to miniaturize as finasteride does. Histogen's approach is similar (although better in my opinion), it could potentially active dormant follicles or even signal new ones to develop. I wouldn't put money on that at this stage though, but it's an interesting area for future research.

If it works it might help to restore hair follicles undergoing miniaturization and may also increase the length of the hair cycle. So it could potentially be a pumped up minoxidil.

Pray The Bald Away · Mar 4, 2016

bbbeeeppp2 said:
It uses the wnt signaling pathway. A key pathway involved in hair follicle neogenesis. It's completely different to Fins mechanism of action, it's basically signalling your hair follicles to grow and develop instead of inhibiting the signal to miniaturize as finasteride does. Histogen's approach is similar (although better in my opinion), it could potentially active dormant follicles or even signal new ones to develop. I wouldn't put money on that at this stage though, but it's an interesting area for future research.

If it works it might help to restore hair follicles undergoing miniaturization and may also increase the length of the hair cycle. So it could potentially be a pumped up minoxidil.

So it doesn't solve the miniaturization problem? The hairs are still dying underneath?

bbbeeeppp2 · Mar 4, 2016

Pray The Bald Away said:
So it doesn't solve the miniaturization problem? The hairs are still dying underneath?

Who knows what it will actually do in practice, we'll need to wait and see what they announce. But as I said, wnt signaling is a key piece of the puzzle in hair follicle development. It's not out of the question that hair follicles in the process of miniaturization might reverse when the wnt pathway is sufficiently activated. Especially if combined with AAs like finasteride and other growth factors.

nameless · Mar 4, 2016

bbbeeeppp2 said:
It uses the wnt signaling pathway. A key pathway involved in hair follicle neogenesis. It's completely different to Fins mechanism of action, it's basically signalling your hair follicles to grow and develop instead of inhibiting the signal to miniaturize as finasteride does. Histogen's approach is similar (although better in my opinion), it could potentially active dormant follicles or even signal new ones to develop. I wouldn't put money on that at this stage though, but it's an interesting area for future research.

If it works it might help to restore hair follicles undergoing miniaturization and may also increase the length of the hair cycle. So it could potentially be a pumped up minoxidil.

Has science even completely mapped the entire hair growth/loss pathway? I don't really think so.

I think that once they do finally map the entire pathway they may find out that all of these things (minoxidil, anti-androgens, Wnt mediators, etc) work at different points on the same pathway.

If I'm wrong and if science has already definitely determined the entire hair loss/growth pathway with CERTAINTY could someone please post a link to that definitive CERTAIN map. Not guess work.

hellouser · Mar 4, 2016

nameless said:
Has science even completely mapped the entire hair growth/loss pathway? I don't really think so.

I think that once they do finally map the entire pathway they may find out that all of these things (minoxidil, anti-androgens, Wnt mediators, etc) work at different points on the same pathway.

If I'm wrong and if science has already definitely determined the entire hair loss/growth pathway with CERTAINTY could someone please post a link to that definitive CERTAIN map. Not guess work.

Swisstemples did a pretty good job of mapping it out:

http://swisstemples.com/prostaglandin-chart/

bbbeeeppp2 · Mar 4, 2016

hellouser said:
Swisstemples did a pretty good job of mapping it out:

http://swisstemples.com/prostaglandin-chart/

We definitely don't know all the signalling pathways involved in Androgenetic Alopecia or hair follicle development yet, plus Swiss's chart only shows prostaglandins. It's likely there are a number of unknown signaling pathways involved in Androgenetic Alopecia and hair follicle cycling/development.

Breyfogle · Mar 4, 2016

Question: How the hell are we going to know what SM says if no one is attending?

Are we hoping for a press release?

Janko · Mar 4, 2016

Dench already wrote it:
https://twitter.com/AADMtgs
https://www.samumed.com/media/

Breyfogle · Mar 5, 2016

Safety, tolerability and efficacy of SM phase 2 announced TOMORROW AT 1PM EST.

Here's their schedule:

https://www.aad.org/scientificsessions/am2016/SessionDetails.aspx?id=9717

Afro_Vacancy · Mar 5, 2016

Knowing our luck, it may be that this treatment is extremely effective and has perverse side effects.

E.g. it's twice as effective as finasteride, doesn't damage your dick, but greatly increases the odds of Alzheimer's.

Armando Jose · Mar 5, 2016

bbbeeeppp2 said:
We definitely don't know all the signalling pathways involved in Androgenetic Alopecia or hair follicle development yet, plus Swiss's chart only shows prostaglandins. It's likely there are a number of unknown signaling pathways involved in Androgenetic Alopecia and hair follicle cycling/development.

A recent study
Foxc1 reinforces quiescence in self-renewing hair follicle stem cells

and
[h=1]FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential
[/h]
http://www.pnas.org/content/early/2016/02/23/1601569113

rambo007 · Mar 5, 2016

https://twitter.com/GaryChoy1

Samumed's employee. Seems positive looking at his tweets. Can someone who have a twitter ask him if they are going to publish result somewhere, today?

el_rizos · Mar 5, 2016

Please , publish any news that is known today about samumed . I'll read to you from Spain . Fingers crossed because we have good news.

nameless · Mar 5, 2016

I think SM04554 will be a pleasant surprise for many disheartened people here.

Pray The Bald Away · Mar 5, 2016

Oh boy, it's almost here! Don't dissappoint me Samumed!

kiwipilu · Mar 5, 2016

can you hear that drum roll in the background?

youngkidwithhairloss · Mar 5, 2016

someone find out the results already lol jk

Pray The Bald Away · Mar 5, 2016

http://www.forbes.com/sites/matthew...omise-in-treating-male-baldness/#5a1f33d51600

SM04554 Phase 2 results

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