Sitri Conference 04.14.2018: Brotzu Presentation - Updates Only

sunchyme1

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Hey I'm hungover on 4loko and moonshine! But srs, I just want to talk to him on an equivalent level in terms of understanding what he's using. Not to mention his measures are quite drastic. I don't criticize at all, I just don't think we see eye to eye on all his treatment methods. But he is one of my favorite posters

bro just use the search function

hes talks about all this stuff in his other posts

life stuff as well
 

Arrade

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bro just use the search function

hes talks about all this stuff in his other posts

life stuff as well
Oh ok. I was just conversing, I didn't know he did. He is a valuable resource for us, but I'm going to disagree with statements like racemic equol is better than s equol, when s equol has no effect on hormones and as far as we know can do an equal job at protecting follicles from DHT.
I don't want someone taking the risks he does if they're 20 when at 31 his body won't be developing and have reverberating effects.
 

Vinc2097

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Well the whole point is to create a single comprehensive solution with everything in it. You shouldn't have to dump multiple solutions on your scalp multiple times a day. That's not sustainable.

So you could do 40 mL of:

60% water
30% PG
10% ethanol

And add:

0.4 grams desloratadine (1%) - assuming this much dissolves in your vehicle (I think it will)
2 grams niacinamide (5%).

Percent is calculated as weight in grams divided by volume in mL.

You should try to take an anti-androgen orally (eg. finasteride) or add one topically as well to the solution or you're not likely to have major success. But you might slow your loss down a bit this way.

Thanks ! very much !

so i can only order desloratadine from chinese website ? all my ''desloratadine buy online'' , ''desloratadine canada order'' research does not work.

and seti / fevi look absent from your post about all treatment you focus on ? is there a reason why
 

Cue Bald

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IdealForehead: sorry if you have been asked these questions before, I did do a search but there are so many posts on these boards it's hard to find anything (it's amusing in a way that there are thousands of hours of posts all about little strands of fibres... :D)

I hear that antihistamines have been able to regrow hair - such as citerizine - to block PGD2. Is there any evidence that antihistamines do anything at all? on success stories and other boards, every result I've seen has basically been down to the big 3. But I mean every little helps and if citerizine works it can't hurt to add it to my regimen.
My understanding of male pattern baldness is that it was caused by DHT in the (vulnerable scalp) follicles, that somehow causes minitiarization of the follicle -nobody knows why or even how DHT causes the follicle to shrink it seems. Perhaps it causes inflamation that physically damages the follicle irreversibly, which means no lotion or pill will ever regrow it (I now doubt that the follicles are permanently damaged as I've seen MTF regimens regrow a lot of hair from SLICK bald scalps)

Where does PGD2 fit into this? or does DHT release this PGD2 which itself shrinks the follicle? (if so, why does an antihistamine inhibit this? is PGD2 a type of histamine?)

If all this is true then a PGD2 inhibitor would basically be a Finasteride (maintainer) without anti-androgenic side effects, it would be a pretty good prophylactic for people with full heads of hair and a family history of male pattern baldness (of course those of us at NW6 wouldn't really benefit from it)
Do you think all this PGD2 stuff is legit or is it just nonsense?


Also there was another medication that apparently regrew hair; it was originally used for eyelash - bimatoprost - apparently it regrew head hair but I haven't found any real results. Apparently this Bimatoprost also involves prostaglandin somehow. (some prostaglandins are produced by the seminal vessicles, perhaps the male pattern baldness one, perhaps why females don't get male pattern baldness)

This guy says that the slick areas of his scalp remained slick, but otherwise it "turned the clock back 1.5 years" - not sure what that means in reality.
https://www.hairlosstalk.com/intera...ults-of-6-mo-usage-of-allergan-lumigan.57385/


Have you heard of this as well? sorry for the massive post. Personally I think a cure will involve either DHT or some kind of prostaglandin. (Either that, or cloning/stem cells, or finding out why hairs grow on wounded tissue) - any other purported "cure" will just be nonsense
 

kawnshawn

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How will Americans get this?
No details yet. The patent has been granted for Europe, so it will obviously be sold there.
I imagine there might be a select few places online a person could buy it and have shipped to America. If not the worst outcome will be having to have someone get it for you in Europe and ship it to you
 

IdealForehead

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Thanks ! very much !

so i can only order desloratadine from chinese website ? all my ''desloratadine buy online'' , ''desloratadine canada order'' research does not work.

and seti / fevi look absent from your post about all treatment you focus on ? is there a reason why

I'll answer further questions ITT with links since they're all things we've been through many times.

I order desloratadine from:
https://www.alibaba.com/product-det...l?spm=a2700.7724838.2017115.34.155d976fx4iBaC

I have not gotten it tested so can't confirm purity, but plan to during my next round of testing.

Seti/fevi are new agents with absolutely zero published data to suggest they actually stop hairloss. So I am not keen on them until proven. My opinion on them vs. androgen receptor antagonists is here:
https://www.hairlosstalk.com/intera...than-enzalutamide.105402/page-60#post-1649939

I have posted about my opinion on them in that I think topical antihistamines, which block PGD2 and many other inflammatory mediators elsewhere as well, make just as much sense or more. For example:
https://www.hairlosstalk.com/intera...really-high-doses.105459/page-12#post-1569350
https://www.hairlosstalk.com/intera...r-loss-and-hair-regrowth.109460/#post-1569406
https://www.hairlosstalk.com/intera...ace-look-like-sh*t.109593/page-3#post-1582962

Until a study comes out proving they are truly effective I am not sold. Right now oral seti costs $400 per month which is insane for an unproven drug when there are stronger agents already out there. Plus it's orally dosed and I prefer topicals.
 
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IdealForehead

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IdealForehead: sorry if you have been asked these questions before, I did do a search but there are so many posts on these boards it's hard to find anything (it's amusing in a way that there are thousands of hours of posts all about little strands of fibres... :D)

I hear that antihistamines have been able to regrow hair - such as citerizine - to block PGD2. Is there any evidence that antihistamines do anything at all? on success stories and other boards, every result I've seen has basically been down to the big 3. But I mean every little helps and if citerizine works it can't hurt to add it to my regimen.
My understanding of male pattern baldness is that it was caused by DHT in the (vulnerable scalp) follicles, that somehow causes minitiarization of the follicle -nobody knows why or even how DHT causes the follicle to shrink it seems. Perhaps it causes inflamation that physically damages the follicle irreversibly, which means no lotion or pill will ever regrow it (I now doubt that the follicles are permanently damaged as I've seen MTF regimens regrow a lot of hair from SLICK bald scalps)

Where does PGD2 fit into this? or does DHT release this PGD2 which itself shrinks the follicle? (if so, why does an antihistamine inhibit this? is PGD2 a type of histamine?)

If all this is true then a PGD2 inhibitor would basically be a Finasteride (maintainer) without anti-androgenic side effects, it would be a pretty good prophylactic for people with full heads of hair and a family history of male pattern baldness (of course those of us at NW6 wouldn't really benefit from it)
Do you think all this PGD2 stuff is legit or is it just nonsense?


Also there was another medication that apparently regrew hair; it was originally used for eyelash - bimatoprost - apparently it regrew head hair but I haven't found any real results. Apparently this Bimatoprost also involves prostaglandin somehow. (some prostaglandins are produced by the seminal vessicles, perhaps the male pattern baldness one, perhaps why females don't get male pattern baldness)

This guy says that the slick areas of his scalp remained slick, but otherwise it "turned the clock back 1.5 years" - not sure what that means in reality.
https://www.hairlosstalk.com/intera...ults-of-6-mo-usage-of-allergan-lumigan.57385/


Have you heard of this as well? sorry for the massive post. Personally I think a cure will involve either DHT or some kind of prostaglandin. (Either that, or cloning/stem cells, or finding out why hairs grow on wounded tissue) - any other purported "cure" will just be nonsense

See the post I just made above for most of the answers.

Also regarding bimatoprost, see here:
https://www.hairlosstalk.com/intera...ol-will-make-your-face-look-like-sh*t.109593/

That explains why I'm not into agents like that.

There are two published studies on topical antihistamines for hair loss, both using cetirizine, both showing significant growth stimulation:

https://www.ncbi.nlm.nih.gov/pubmed/28604133
http://onlinelibrary.wiley.com/doi/10.1111/jdv.13864/abstract

Again, I use desloratadine instead of cetirizine because of this:
https://www.hairlosstalk.com/interact/threads/degradation-of-cetirizine-in-alcohol-vehicles.66061/
 

Kev123

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Funny fact about Brotzu: During the conference tricologists in the room asked the sh*t out of Brotzu lol , however he insisted on mentioning the results with wash tests, pull tests and AA. Apparently the atmosphere was really tense

Good enough for his hardcore followers though.
 

Cue Bald

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See the post I just made above for most of the answers.
Also regarding bimatoprost, see here:
https://www.hairlosstalk.com/intera...ol-will-make-your-face-look-like-sh*t.109593/

That explains why I'm not into agents like that.

damn it seems you get nothing in this world for free.
i also don't use minoxidil because of the puffy face / eye bags etc
 

kiwipilu

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guys do you have any infos about the conference on histamines at sitri? was it about ceti or other potential drug?
 

alibaba92

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On a second thought, the result for the female in the presentation is impressive, as such, we can hope that they will release the product for the ladies (worst case), so the guys can buy to try
 

jared garnith

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No I am not using minoxidil anymore. That's why I said "or a custom base of 50% propanediol, 30% ethanol, 20% water". I am using my custom base now instead. You can use propanediol, propylene glycol, or dipropylene glycol for the 50%.

Propylene gylcol has the highest solubility for most things but can be a bit more irritating to the skin for people who are sensitive to it.
do you know of any other users using desloratadine and if they had any success with it?
 

WendyPayne

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Seriously, waiting for something without putting in any effort, and not using the methods and treatments available today, it is so stupid. That's why I became an atheist in general. All that is offered to you is to believe and hope, while you aren't allowed to use a lot of stuff related to medicine that will obviously help you. For example, for those who have problems with hair growth, I would highly recommend the company https://www.prendo.com/. They are engaged in simulations of various situations, and thus they can predict what awaits you in the future, and what can be avoided. As for hair, they will also collect statistics and show what you will become in a year or several years, as well as give advice on how you can improve hair growth.
 
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