Samumed Sm04554 Results Normalized To Baseline

[nick123]

Based on their unimpressive results there are Wnt agonists already on the market that will meet or exceed SM's potential. Instead of waiting for SM just use VPA, it's probably more potent.

Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis - PubMed

Valproic acid (VPA), a widely used anticonvulsant, inhibits glycogen synthase kinase 3β and activates the Wnt/β-catenin pathway, which is associated with hair growth cycle and anagen induction. To assess the efficacy of topical VPA for treating androgenetic alopecia (Androgenetic Alopecia), we performed a...

pubmed.ncbi.nlm.nih.gov

If you aren't a responder to minoxidil you can take oral minoxidil, which has a 100% response rate, or get minoxidil sulfate powder and mix it yourself, also 100% response rate. Microneedling and tretinoin also turn minoxidil non-responders into responders. Or you can go the PGF2a route, latanoprost and bimatoprost are already on the market and equivalent to minoxidil. SM will not perform as well as minoxidil so it's pretty much useless. If you get side effects from minoxidil or pgf2a analogues then just use VPA instead of waiting for SM. There's no drug more advanced than minoxidil coming in the next 5 years, but you can get KY19382 on the grey market which might exceed minoxidil.

Oh wow, I had no idea Valproic acid worked as well as it does for a readily available wnt agonist. Although I don't know anyone who actively uses it? Is there any reason to why it's not more widely used?

 

[jamesbooker1975]

Oh wow, I had no idea Valproic acid worked as well as it does for a readily available wnt agonist. Although I don't know anyone who actively uses it? Is there any reason to why it's not more widely used?

It can go systemic, However People all use Ru, that there is not even studies don in human and can go systemic, so.... I guess not influencer use it yet and that is the only valid reason.

 

[pegasus2]

Oh wow, I had no idea Valproic acid worked as well as it does for a readily available wnt agonist. Although I don't know anyone who actively uses it? Is there any reason to why it's not more widely used?

Because minoxidil is better

 

[nick123]

Because minoxidil is better

Minoxidil is better at regrowth for sure but is it a better Wnt agonist than VPA? Surely we can use both together?

 

[trialAcc]

Based on their unimpressive results there are Wnt agonists already on the market that will meet or exceed SM's potential. Instead of waiting for SM just use VPA, it's probably more potent.

Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis - PubMed

Valproic acid (VPA), a widely used anticonvulsant, inhibits glycogen synthase kinase 3β and activates the Wnt/β-catenin pathway, which is associated with hair growth cycle and anagen induction. To assess the efficacy of topical VPA for treating androgenetic alopecia (Androgenetic Alopecia), we performed a...

pubmed.ncbi.nlm.nih.gov

If you aren't a responder to minoxidil you can take oral minoxidil, which has a 100% response rate, or get minoxidil sulfate powder and mix it yourself, also 100% response rate. Microneedling and tretinoin also turn minoxidil non-responders into responders. Or you can go the PGF2a route, latanoprost and bimatoprost are already on the market and equivalent to minoxidil. SM will not perform as well as minoxidil so it's pretty much useless. If you get side effects from minoxidil or pgf2a analogues then just use VPA instead of waiting for SM. There's no drug more advanced than minoxidil coming in the next 5 years, but you can get KY19382 on the grey market which might exceed minoxidil.

Isn't minoxidil sulfate powder pretty unstable? I thought there were issues around mixing that yourself.

Also, VPA is interesting, but is the topical on the market? I thought it was just an oral medication.

 

[pegasus2]

Isn't minoxidil sulfate powder pretty unstable? I thought there were issues around mixing that yourself.

Also, VPA is interesting, but is the topical on the market? I thought it was just an oral medication.

It is unstable, but you can make weekly batches in a non-aqueous solution.

VPA raw powder is very cheap, you can make the topical yourself. People have been using it for at least ten years on the forums.

 

[trialAcc]

It is unstable, but you can make weekly batches in a non-aqueous solution.

VPA raw powder is very cheap, you can make the topical yourself. People have been using it for at least ten years on the forums.

Is there a user thread anywhere you could link me to?

 

[trialAcc]

No great responders come to mind. The kind of hair growth you can get from stuff like this is not picture worthy. Only the top responders to minoxidil and finasteride/dutasteride get cosmetic results. Excluding HRT. Maybe KY19382 will join that group.

I'm more looking for maintenance level results without using RU, not some growth explosion.

 

[jd_uk]

No great responders come to mind. The kind of hair growth you can get from stuff like this is not picture worthy. Only the top responders to minoxidil and finasteride/dutasteride get cosmetic results. Excluding HRT. Maybe KY19382 will join that group.

Do you think there's anything other then min/finasteride/dutasteride (and obviously HRT) that can provide cosmetic results? E.g. breezula when it comes out? I heard there's a group buy for ordering fluridil at 7.5% concentration too..could that have potential?

Btw seeing something about risk of cancer from sm on the second page of this thread..that sounds concerning. Like hair is important but...

 

[jd_uk]

I'm more looking for maintenance level results without using RU, not some growth explosion.

Difficult thing abour maintenance results is who is to say what would have happened without the medications... some people just develop receding hairlines and then not much after that..or thin and then stop thinning. About 10 years ago I was told on this site that if i didn't use finasteride I'd be NW6 by now. Well my hair is definitely not in as good shape as it was but I'm nowhere near NW6 (even though that is probably my thinning pattern). I'm around NW3V in reality and back then I was more like NW2 with only slight thinning at the crown.

 

[pegasus2]

Do you think there's anything other then min/finasteride/dutasteride (and obviously HRT) that can provide cosmetic results? E.g. breezula when it comes out? I heard there's a group buy for ordering fluridil at 7.5% concentration too..could that have potential?

Btw seeing something about risk of cancer from sm on the second page of this thread..that sounds concerning. Like hair is important but...

Breezula and RU, but the results probably don't even last as long as minoxidil which is not long.

 

[jd_uk]

Breezula and RU, but the results probably don't even last as long as minoxidil which is not long.

Wouldn't the results last longer than minoxidil though if their mode of action is stopping DHT at the follicle? Not convinced on fluridil? I was excited about the idea of getting it at higher concentration but sounds like it needs to be stored in the freezer which for me is pretty impractical especially considering travel.

What's your hair situation and routine BTW?

 

[pegasus2]

Wouldn't the results last longer than minoxidil though if their mode of action is stopping DHT at the follicle? Not convinced on fluridil? I was excited about the idea of getting it at higher concentration but sounds like it needs to be stored in the freezer which for me is pretty impractical especially considering travel.

What's your hair situation and routine BTW?

They should be, but it doesn't look like it for reasons I don't care to speculate about.

Not enough to join the group buy for it.
My routine is complicated lol

 

[jd_uk]

They should be, but it doesn't look like it for reasons I don't care to speculate about.

Not enough to join the group buy for it.
My routine is complicated lol

Would be interested to hear it sometime. Both your routine but also about why you think things like CB or even RU won't work very long.

 

[nick123]

Would be interested to hear it sometime. Both your routine but also about why you think things like CB or even RU won't work very long.

Here are the CB 1 year results, see for yourself the drop after 6 months.

 

[Roeysdomi]

Here are the CB 1 year results, see for yourself the drop after 6 months.
View attachment 158608

That make me think that using CB make your folicels even more sensetive long term. Meaning when you stop using it , you would lose faster then if you never used it before.

 

[jd_uk]

Here are the CB 1 year results, see for yourself the drop after 6 months.
View attachment 158608

Hm. I was aware of that but wasn't sure if it were the dose or vehicle they plan to make available. Hopefully the phase 3 might show better results (although perhaps that's not what they're testing for at phase 3). Shame we can't see data over 2 years.

Any idea what OD means btw? I know BID is twice a day.

 

[5minutesbeforemiracle]

Any idea what OD means btw? I know BID is twice a day.

OD = Once daily
BID = Twice daily

 

[jd_uk]

OD = Once daily
BID = Twice daily

Ah, of course.

 

[MrJolly26]

Then I want him to be richer! Just need that this new brotion works, so fingers crossed while we wait for news.