Samumed Sm04554 Results Normalized To Baseline
- Thread starter hypetraintime
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What tells you they are legit? Intuition?
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If this never gets released I swear I'll give up, shave my head and use a cap for the rest of my life.
charlie76761
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Also seems to dissolve in DMI - similar to DMSO but less harsh
Flamingflaps
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I feel you. Having one of those bad hair days and feeling desperate for some more info on this. I should curtail my anticipation as we all know how these things tend to play out...
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Is either this or basically not cutting my hair anymore until I die. We won't be on quarantine forever so there is very unlikely
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It could be the worst company ever, as long as I get even some hair back I don't give a fck.This can be interesting in regards to the article from that former employee that was posted, some reviews of working at samumed:
They get at 3.7/5 score
Working at Samumed
See what employees say it's like to work at Samumed. Salaries, reviews, and more - all posted by employees working at Samumed.www.glassdoor.com
They're laying it on thick here but I do agree with some of the points they made. A lot of the ideas and emerging trends in medicine right now have actually been around or researched in prior decades, with the only difference now being timing. Money is flowing into biotech right now, and VC firms wealthy off of their success in tech are eager to finance startups that have access to research that previously wouldn't have gotten funding and push them to market in untapped industries. Hair happens to be one of these, but so are largely untreated genetic conditions that big pharma has kept it's distance from due to the numbers game.Another article about Samumed.
More Time To Think: How A $12 Billion Biotech Startup Freed Up Its…
They had found the recipe For Anti-Aging. The only question was: How Could They Empower Their Team To Turn It Into A Reality?procurify.medium.com
And no wonder Osman has great hair at his age, could be that the CEO already uses his own product
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In many cases, the research that gets turned into eventual therapies or cures will come from research that was never pursued due to funding reasons.
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I think I'll change my username. I think by the end of the year I'll be completely bald
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You're going to die bald, no matter what timelines you read on Folliclethought.
Shedding is not surprising considering phase 2 results. Anyway, good luck.
could you please elaborate more?
for me shedding should occur, as to change the phase of follicule, you need to change the hair ( like minoxidil) but it's taking ages...
I think it depends on individuals, but if the average guy shows shedding in the first months, then there is a chance that you got a noticeable shedding in the same period of time.
First of all I hope your brother and you avoid the MD. Fingers crossed mate.
But I would like to touch upon this discussion as well.
I've been following Parkinson research space for the past 6 months and it seems like an apt comparison for multiple reasons.
PD is not a disease it is more of a syndrome that gathers multiple different causes together because they all lead to similar symptoms.
There are several variants of PD the idiopathic one is the one that happens to most older people (above 50), however there are multiple variants that happen due to multiple possible mutations on gene or genes that are grouped together (PARKIN, PINK1, GBA, SNCA etc.). So basically as you both mentioned those variants are polygenic diseases and would require multiple edits which is definitely a difficult task.
Why did I use this comparison? Because just like Androgenetic Alopecia finding the exact cause of PD (all of the variants) eludes us. This is why I like to compare both.
Thankfully in the case of Androgenetic Alopecia we don't really need to find the culprit. We just need to clone hair follicles and transplant them. Basically I agree with you. We are 15-20 years away from the gene route. However we are definitely close to the cloning part. The timeline will be much more clear when a company like Stemson/ Tsuji/ Hewitt starts their clinical trials.
However when it comes to the new age of medicine and fixing polygenic diseases by fixing genes themselves the cure is still far away.
But that doesn't mean we are not closer to actually treating those diseases. For example a PARKIN PD variant might be due to the oxidative changes causing a certain PARKIN protein to become insoluble. However instead of fixing the genes causing the oxidation of the protein we could supply the soluble version of protein making that variant a treatable disease instead. This is not a cure but just making neurodegenerative diseases treatable would a massive step forward.
To get back to Androgenetic Alopecia one could say that it is already treatable but all of us are here because we know that the current treatments are not good enough. They are just slowing the progression and for a lot of people on this forum not sufficiently or with too grave of side effect profile.
Better treatments might be upon us! SM here might be something like that. I am eagerly awaiting Phase 3 results.
Haha it doesn't look like either of us avoided it, but I do hope we will have a treatment in the next 3-6 years that will spare us from the bulk of the skeletal muscle issues. Thank you for the well wishes!
The science is so well understood and the issue is so well defined (with the muscles) that I think we will be spared from the worst aspects of the condition. Parkinson is a bit different, because as you said, multiple variants and multiple mutations of different genes. Our form of muscle dystrophy is 1 single mutation on the DMPK gene that causes repeat toxic RNA expansions that inhibit different proteins in different systems. The same mechanism as Huntington's disease but the brain's motor neurons are not the target, but both are repeat expansion disorders. You don't even need to alter the DNA to cure both huntingtons and DM, you just need to eliminate the toxic expansions that alter normal functions. Luckily for us and people with huntingtons', small molecule RNA nucleotides are finally able to finally target the toxic RNA and maybe 5-8 different companies are racing to the clinic right now, and dozens for huntingtons. This isn't even the gene therapy path, which offers even yet another path to cure/disrupt both diseases by making 1 time changes to the RNA that eliminates the expansions all together. This is probably 10-15 years away at the current pace, but technology could speed that up.
Either way, you are correct that we are quite far from even cures of single point mutations like the two diseases above, but treatment with significant modification of disease course is very close from a clinical standpoint (ie under 10 years for currently orphan diseases).
For Androgenic Alopecia, the issue is actually much more simple then I think people really give credit (in the grand scheme of things) because like you said, you can tackle the issue and effectively cure the condition without actually curing the polygenic genetic factors that are responsible for the overall condition. I think we will see dozens of similar start-ups to Moogene in the next 5-10 years all racing towards a targeted approach that stops at the follicles and doesn't hit the system as the science behind targeted small molicule medicines and gene alterations becomes more advanced and common place. The real issue here is that traditionally AA has been ignored almost completely by medicine, as funding goes to the high priority areas rather then something seen as cosmetic. The current bull market in venture capital has changed this though, and VC firms are actually looking for big ticket items like balding cures and anti-ageing in general.
I too am eagerly waiting the results of this though. I'm more positive on it then post people are around here, probably because I can actually put phase 1/2 testing into context. Most people saw the 10% increase in hair count (at 90-125 days of course) and instantly wrote it off. Not many hair treatments work to their actual potential in a 90 day dosage period, and we all know phase 2 is aimed at exploring dosage and safety, rather then pure efficacy.
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