Samumed Sm04554 Results Normalized To Baseline

[nick123]

We're talking about Turkey, you will be able to get it, prescription or not. Btw, if we're lucky, this could be approved this year in Turkey already. But of course because of the 'rona, I'd keep expectations low in that regard.

Not really familiar with Turkey to be honest.. I wonder if a bunch of turkish resellers will pop up and ship to other countries.

 

[MrV88]

Not really familiar with Turkey to be honest.. I wonder if a bunch of turkish resellers will pop up and ship to other countries.

I think it won't be some sh*t like Kane that is sold over the counter. Depends on the treatment, probably something you get done in private clinics and/or hair clinics. If it's something you could buy in apothecaries it will be available soon all over or you can at least get your order in 5-48 hours, no need for shady guys that charge you more if Turkey really approves it.

Could take years to get an FDA or EMA approvement, if at all.

 

[John Difool]

I added SM abput a year ago. At 0.15% this is a financial no brainer. I am planning to buy a year batch (that I will test for validity and purity) to renew my stach so if anyone is interested PM me now.

 

[wow-wow]

I added SM abput a year ago. At 0.15% this is a financial no brainer. I am planning to buy a year batch (that I will test for validity and purity) to renew my stach so if anyone is interested PM me now.

Did you test it?
What is your results and other regimen?

 

[TurboFixer]

If you go deep into Samumed's history and watch their presentations, they aren't some random company making some random drugs. They have stumbled upon a method that allows them to create a platform, not just one hit wonder drugs like Clascoterone (one drug they rub everywhere for different effects). They are able to slightly modify their approach and tackle many degenerative diseases with their secret sauce.

If you dive deep into their history, you can see that Samumed was a spin off from Wintherix & Epitherix (founded by some pretty notable researchers) (pre 2008) which was a startup backed by Pfizer. The relationship eventually turned sour. The technology was at the centre of a battle for rights between Pfizer and Wintherix where Pfizer eventually settled in 2012 and gave over the IP. This was then spun into Samumed who didn't even start advertising a research pipeline until 2016, nearly 10 years after the beginning. From basically nothing to 2018, where they were listed as one of the most valuable companies you have never heard of, around 12 billion. They know something and have made it a point to only let the results of their clinical trials do all the talking (which take time).

A lot of people subscribe to the idea that DRUG -> INDUCE GROWTH or MORE DRUG (higher %) -> INDUCE MORE GROWTH. This works for something like minoxidil, but it's not what Samumed is trying to do. Knowing what I know about Samumed's history and how they are trying to selectively target pathways to restore original function (inhibit or activate), not augment (chemically like finasteride), I subscribed to DRUG -> RESTORES FOLLICLE FUNCTION -> INDUCE GROWTH (like a normal head). An equivalent idea would be something like a pacemaker, which is basically used to help regulate abnormal heart rhythms back to normal. It fixes the problem and lets the heart operate like normal. So basically, fix the follicle, then let the body take over and do what it does best, grow hair.

When they released their phase 2 results, everyone was mad that a higher concentration produced less results with only moderate hair growth in the lower concentration group. Again, knowing what I think Samumed is trying to achieve (restore function), most people seemed to miss the most important detail.. that hair continued to grow after the drug was stopped. This could indicate that the follicles were actually repairing (big news). I believe Samumed was trying to find the exact concentration which activates the wnt pathway just enough to restore follicle function for Androgenetic alopecia suffers, not directly grow hair. Once the follicle is working again, the hair will follow. But, this takes time (almost like a baby growing their hair), It will take a few cycles to mature back to thick terminal.

So my theory is that Samumed believes faulty wnt signalling (inhibited) within the follicle is a main driver of balding and by selectively activating it, they can reinstate the follicles original function. So finasteride and minoxidil will help get back a lot of gains faster, but at a certain point, SM would have healed your follicles to the point that it's equivalent to applying minoxidil or finasteride to someone who isn't balding.. It's doing nothing. Then the continuation of SM would be needed to keep the pathways responsible for regulating the follicle functioning properly.

If you stopped SM, you would begin balding again, but starting from healthy follicles. So it could be years before you even started to notice you were balding again.

Also, aliens are real.

But who knows, we will find out soon enough ¯\_(ツ)_/¯

big if true

not worth holding breath though been let down to many times.

 

[John Difool]

Combined @bridgeburn and @pegasus2.regimens: SAG PGE2 WAY3 RU E2 P4 BICA Results similar to @Itsnoahkennedy.

I only test large batches. It's more economically sound that way. Therefore the group buy.

 

[Frenchboy]

Combined @bridgeburn and @pegasus2.regimens: SAG PGE2 WAY3 RU E2 P4 BICA Results similar to @Itsnoahkennedy.

I only test large batches. It's more economically sound that way. Therefore the group buy.

What about the sides ? I don't know all the things that you're taking haha, are they anti-androgens or not ?

 

[John Difool]

You need AA either topical or oral for any effective regimen to function. Unless you transition and make sure no backdoor pathway is still activated. My goal is to regrow then dial down back to basic stuff. Do I get sides? Lol, of course I do! E2 & Bica are definitely not side free. Every treatment presents risks that you need to understand first then decide is it worth it. Regrowing hair is definitely worth it for me.

 

[Frenchboy]

You need AA either topical or oral for any effective regimen to function. Unless you transition and make sure no backdoor pathway is still activated. My goal is to regrow then dial down back to basic stuff. Do I get sides? Lol, of course I do! E2 & Bica are definitely not side free. Every treatment presents risks that you need to understand first then decide is it worth it. Regrowing hair is definitely worth it for me.

Ok it's your choice, no matter what I think. I'm from france, only on finasteride since 6 month.
I was wondering that the SM04554 would be side free and be use without finasteride or minoxidil, but I think now we need to wait for the results of the phase III to have a vision.

 

[MrV88]

So basically this treatment will bring back dormant follicles or thicken more or less half dead zombie follicles? Is it about the hair itself or maybe about the skin around it too, so that it can form new follicles?

 

[RolfLeeBuckler]

HOW THE f*** DOES IT NEED FOR SAMUMED TO COMMERCIALIZE THE PRODUCT 1 YEAR AFTER PHASE III RESULTS?

THEY HAVE SHOWN SAFETY AND EFFICACY AT 625 PEOPLE: WHY COMMERCIALIZATION IN 2022 AND NOT IN APRIL 2021.

this f*****g MRNA covid19 vaccine is approved within half year and for a f*****g hairloss topical they need 5 years!!!!!!!!!

#fuckTSUJI
#fuckTISSUSE
#fuckSHISEIDO
#fuckYOUNGJET

 

[Tom4362]

HOW THE f*** DOES IT NEED FOR SAMUMED TO COMMERCIALIZE THE PRODUCT 1 YEAR AFTER PHASE III RESULTS?

THEY HAVE SHOWN SAFETY AND EFFICACY AT 625 PEOPLE: WHY COMMERCIALIZATION IN 2022 AND NOT IN APRIL 2021.

this f*****g MRNA covid19 vaccine is approved within half year and for a f*****g hairloss topical they need 5 years!!!!!!!!!

#fuckTSUJI
#fuckTISSUSE
#fuckSHISEIDO
#fuckYOUNGJET

Bro you just destroyed the dopamine spike I got from seeing a new post in this thread

 

[RolfLeeBuckler]

Relax man, we could see it this year in Turkey.

Bro, please explain me how you supect, that SM04554 could be avialable this year in turkey?

 

[RolfLeeBuckler]

Already talked about this on the previous page. The turkish stage III trail should be completed this month, so if the turkish medical authorities work fast enough they could approve it this year. We should try to find how fast they approve after stage III.

do you think that we will get Samumed's plan for commercialization in the moment the Phase 3 results are published?

 

[Frenchboy]

I red that the results will be published in march 2021. A member from here sent them an email to ask them.
I'm trying to do the same, i will tell you.

 

[RolfLeeBuckler]

I red that the results will be published in march 2021. A member from here sent them an email to ask them.
I'm trying to do the same, i will tell you.

so the member told ya in personal chat?

I also read the info that they possibly will publish in march at folliclethought or hlc2020. The reason of that is that Samumed always publish results 2 months later after the trial finished

 

[RolfLeeBuckler]

I red that the results will be published in march 2021. A member from here sent them an email to ask them.
I'm trying to do the same, i will tell you.

are you able to answer my question NOW?
i am tired of waiting so answer me

 

[Frenchboy]

are you able to answer my question NOW?
i am tired of waiting so answer me

wtf bro
we are on a forum, not twitter, relax
here : https://www.hairlosstalk.com/intera...4554-only-drug-on-phase-3.130290/post-1924485

 

[John Difool]

are you able to answer my question NOW?
i am tired of waiting so answer me

Baldness is not just a cosmetics issue. It's psychologically impacting the brain of people to refrain them from speaking calmly and respectfully.

 

[John Difool]

this f*****g MRNA covid19 vaccine is approved within half year and for a f*****g hairloss topical they need 5 years!!!!!!!!!

Because covid unlike male pattern baldness does kill people and commercialising it quickly with a lower safety margin presents more benefits even with some risks? I mean, who wants to die from a hair treatment that has been approved in a rush?