- Reaction score
- 119
Samumed update (just a statement about old data)
https://www.samumed.com/medium/imag...s-phase-2-biopsy-study-for-a-pot_63/view.aspx
https://www.samumed.com/medium/imag...s-phase-2-biopsy-study-for-a-pot_63/view.aspx
I'm not picky. This causes neogenesis? Sure, sounds good. I'll get a transplant and use this and stay on finasteride and minoxidil. Potentially rebuild the donor after a year and repeat. I'll take what I can get. It's a totally different mechanism of action than finasteride. Might be that this works well with wounding too.
I hope they continue the research. We haven't even seen what this could do for a head that's on finasteride where the DHT isn't inhibiting follicular neogenesis.
Take all the drugs and get a FUE. You'll see me randomly shirtless in the grocery store all like:
You can't get neogenesis in scar tissue.
Neogensis mean the results are permanent right? If you stop the treatment you won't shed.
Yeah, as if ANY of those f*****g experimental lotions/research are anywhere near as making us inmune.
Castration is always the answer to Androgenetic Alopecia arrest.
Tranny regimen you might get your hair back to some extent.
The tranny regime has given nw4/5 to nw1 . Just looked at the recent log on here. Its funny all these companys trying to birth folicles when it would appear they never die
You mean..
Painful to look at. Androgenetic Alopecia is damn brutal.
Pray for Tsuji mate.
Hahaha i got my hands in prayer right now
You mean..
Painful to look at. Androgenetic Alopecia is damn brutal.
Pray for Tsuji mate.
That right there along with what Dr. Cotsarelis said a few years back is solid evidence that follicles DEFINITELY don't die. I wonder what makes the DP count increase in the follicles?
Dr. Van Voorhees: What is the mechanism that accounts for the miniaturization of hair?
Dr. Cotsarelis: We know that inhibiting the testosterone pathway slows down the miniaturization of the follicle. Jaworsky, Kligman, and Murphy had a paper 20 years ago showing that half the time there is also inflammation around the hair follicle, which led to some thought that maybe inflammatory cells including mast cells were contributing to hair loss. Studies and case reports of transgender operations where men become women and receive high doses of estrogen show that a scalp that was almost completely bald can have, after castration and high estrogen supplementation, a tremendous amount of hair growth.
Those pictures are absolutely outrageous. The woman on the bottom goes from a legit 6.5 to a NW0. That is both highly encouraging and disheartening at the same time.
So what is it about estrogen that helps so much ?
What mechanism is estrogen on the scalp... pge1 ?
We can mimick this without effecting our dicks im sure of it
Gene Fold Change
FLNA 2.18
COMP 2.16
KRT19 1.92
KRT2 1.92
TAGLN 1.87
SRRM2 1.86
KRT75 1.85
LAMA5 1.76
PDLIM7 1.73
KRT37 1.73
KRT17 1.7
NKTR 1.64
MAGEA11 1.63
COL18A1 1.61
PMEL 1.57
ATP5D 1.56
ACTB 1.56
KRT14 1.55
COL6A2 1.54
CSPG4 1.54
MAP2K2 1.52
PTK7 1.52
GSTP1 1.52
CCND1 1.52
ERCC2 1.52
NFATC4 1.51
COL11A1 1.51
COL16A1 1.49
TKT 1.49
PPP1R13L 1.49
FOSL2 1.48
NDUFA3 1.47
KRT5 1.46
BASP1 1.44
MGP 1.43
EGFR 1.42
Gene Fold Change
MMP3 0.18
FLG 0.2
MMP1 0.32
SPP1 0.33
JAK1 0.35
FN1 0.36
ITGAV 0.37
SOD2 0.38
FGFR2 0.39
CDKN2B 0.4
GLRX 0.41
HACL1 0.41
AIM1 0.42
COL12A1 0.42
CDH1 0.43
CDKN1A 0.43
DCN 0.43
S100A9 0.44
SPRR2D 0.44
EPS8 0.44
HK2 0.45
CD36 0.45
S100A7 0.46
SPRR1A 0.46
SOCS5 0.46
NOV 0.47
LCN2 0.48
SPARCL1 0.48
MCL1 0.49
SDCBP 0.5
GJA1 0.5
TDG 0.5
CANX 0.5
CASP2 0.5
NID1 0.51
SERPINE1 0.51
IL1A 0.51
EDNRB 0.52
PTGDS 0.52
TNFRSF19 0.52
TXLNA 0.52
CCNG2 0.53
DSC1 0.53
ITGA6 0.53
CXCL1 0.53
IQGAP1 0.54
ITGB6 0.54
PDLIM5 0.54
MAPK14 0.54
DDX3X 0.55
EMP1 0.55
UBQLN1 0.56
TJP2 0.56
IL6 0.56
PLIN2 0.56
RAF1 0.56
EPS15 0.57
ITGA2 0.57
PPIL4 0.57
CALR 0.57
CCT8 0.57
EIF4H 0.58
ADAM9 0.58
ABCC5 0.58
MAPK6 0.59
SEC31A 0.59
HIF1A 0.6
GLUL 0.6
FOS 0.6
STAT2 0.6
STAT1 0.6
CCT4 0.6
FCGR1A 0.6
FMOD 0.61
VCAN 0.61
BCL2L13 0.62
COL6A3 0.62
THBS2 0.62
UNG 0.62
VEGFA 0.62
THBS1 0.62
LTBP1 0.62
ASAH1 0.62
GCLC 0.62
TNFRSF1A 0.62
CCNC 0.63
KRT38 0.63
MAPK1 0.63
CLU 0.63
IGFBP3 0.63
CD55 0.63
MCC 0.63
CASP8 0.63
HSPD1 0.64
S100A8 0.64
CORO1C 0.64
CDH5 0.64
TFDP1 0.64
DNAJA3 0.64
ERO1A 0.65
ABCB6 0.65
CD44 0.65
CGA 0.65
LUM 0.65
CDKN1B 0.65
PSAP 0.65
TGFA 0.65
CASP7 0.65
HADHB 0.65
GLIPR1 0.65
MFAP3 0.65
BCL10 0.65
PTK2 0.65
KRT1 0.65
CD34 0.66
ACOX1 0.66
VHL 0.67
EIF3E 0.67
BCL2L2 0.67
PSEN1 0.67
TNFSF10 0.67
LDLR 0.67
RIPK1 0.67
KRT36 0.67
PIM1 0.68
GJB2 0.68
B2M 0.68
LAMA4 0.68
XRCC5 0.68
CPE 0.68
HOPX 0.69
P4HB 0.69
PRKCH 0.69
LGALS8 0.69
MFAP5 0.69
VBP1 0.69
BCL2L1 0.69
ITGB1 0.7
CWC27 0.7
TP53 0.7
CTNNB1 0.7
MCM5 0.7
PDZK1IP1 0.7
Genes upregulated by estrogen in male hair follicles:
Code:Gene Fold Change FLNA 2.18 COMP 2.16 KRT19 1.92 KRT2 1.92 TAGLN 1.87 SRRM2 1.86 KRT75 1.85 LAMA5 1.76 PDLIM7 1.73 KRT37 1.73 KRT17 1.7 NKTR 1.64 MAGEA11 1.63 COL18A1 1.61 PMEL 1.57 ATP5D 1.56 ACTB 1.56 KRT14 1.55 COL6A2 1.54 CSPG4 1.54 MAP2K2 1.52 PTK7 1.52 GSTP1 1.52 CCND1 1.52 ERCC2 1.52 NFATC4 1.51 COL11A1 1.51 COL16A1 1.49 TKT 1.49 PPP1R13L 1.49 FOSL2 1.48 NDUFA3 1.47 KRT5 1.46 BASP1 1.44 MGP 1.43 EGFR 1.42
Genes downregulated by estrogen in male hair follicles:
Code:Gene Fold Change MMP3 0.18 FLG 0.2 MMP1 0.32 SPP1 0.33 JAK1 0.35 FN1 0.36 ITGAV 0.37 SOD2 0.38 FGFR2 0.39 CDKN2B 0.4 GLRX 0.41 HACL1 0.41 AIM1 0.42 COL12A1 0.42 CDH1 0.43 CDKN1A 0.43 DCN 0.43 S100A9 0.44 SPRR2D 0.44 EPS8 0.44 HK2 0.45 CD36 0.45 S100A7 0.46 SPRR1A 0.46 SOCS5 0.46 NOV 0.47 LCN2 0.48 SPARCL1 0.48 MCL1 0.49 SDCBP 0.5 GJA1 0.5 TDG 0.5 CANX 0.5 CASP2 0.5 NID1 0.51 SERPINE1 0.51 IL1A 0.51 EDNRB 0.52 PTGDS 0.52 TNFRSF19 0.52 TXLNA 0.52 CCNG2 0.53 DSC1 0.53 ITGA6 0.53 CXCL1 0.53 IQGAP1 0.54 ITGB6 0.54 PDLIM5 0.54 MAPK14 0.54 DDX3X 0.55 EMP1 0.55 UBQLN1 0.56 TJP2 0.56 IL6 0.56 PLIN2 0.56 RAF1 0.56 EPS15 0.57 ITGA2 0.57 PPIL4 0.57 CALR 0.57 CCT8 0.57 EIF4H 0.58 ADAM9 0.58 ABCC5 0.58 MAPK6 0.59 SEC31A 0.59 HIF1A 0.6 GLUL 0.6 FOS 0.6 STAT2 0.6 STAT1 0.6 CCT4 0.6 FCGR1A 0.6 FMOD 0.61 VCAN 0.61 BCL2L13 0.62 COL6A3 0.62 THBS2 0.62 UNG 0.62 VEGFA 0.62 THBS1 0.62 LTBP1 0.62 ASAH1 0.62 GCLC 0.62 TNFRSF1A 0.62 CCNC 0.63 KRT38 0.63 MAPK1 0.63 CLU 0.63 IGFBP3 0.63 CD55 0.63 MCC 0.63 CASP8 0.63 HSPD1 0.64 S100A8 0.64 CORO1C 0.64 CDH5 0.64 TFDP1 0.64 DNAJA3 0.64 ERO1A 0.65 ABCB6 0.65 CD44 0.65 CGA 0.65 LUM 0.65 CDKN1B 0.65 PSAP 0.65 TGFA 0.65 CASP7 0.65 HADHB 0.65 GLIPR1 0.65 MFAP3 0.65 BCL10 0.65 PTK2 0.65 KRT1 0.65 CD34 0.66 ACOX1 0.66 VHL 0.67 EIF3E 0.67 BCL2L2 0.67 PSEN1 0.67 TNFSF10 0.67 LDLR 0.67 RIPK1 0.67 KRT36 0.67 PIM1 0.68 GJB2 0.68 B2M 0.68 LAMA4 0.68 XRCC5 0.68 CPE 0.68 HOPX 0.69 P4HB 0.69 PRKCH 0.69 LGALS8 0.69 MFAP5 0.69 VBP1 0.69 BCL2L1 0.69 ITGB1 0.7 CWC27 0.7 TP53 0.7 CTNNB1 0.7 MCM5 0.7 PDZK1IP1 0.7
Source: Substantial Sex-Dependent Differences in the Response of Human Scalp Hair Follicles to Estrogen Stimulation In Vitro Advocate Gender-Tailored Management of Female Versus Male Pattern Balding
If you figure out a way to mimic this, let us know.
Would you rather lose your balls or your hair?
I know SARMS ( selective androgen receptor modulator )are being designed to act like steroids with minimal side effects.
!