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Ru58841 Side Effects, Lethargy En Lack Of Sleep

Discussion in 'Antiandrogens - Propecia, Dutasteride, etc.' started by ryan r, Apr 14, 2020.

  1. ryan r

    ryan r Established Member

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    Hi all,

    I think I may have gotten bad sides from RU usage. As of lately, I have gotten extremely lethargic, also my sleep quality has suffered significantly.

    Has anyone else noticed this or any other sides on RU, and how long did it take for the sides to disappear?

    It is a shame, because I really hoped RU combined with dutasteride was a winning combo for me. dutasteride still works, but not sure if my hairline will hold.

    Hope to hear your thoughts!
     
  2. Pigeon

    Pigeon Senior Member My Regimen

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    Duta and RU are both strong anti androgens.

    Lethargy and problems with sleep are known side effects.
     
  3. Hair-pun

    Hair-pun Established Member My Regimen

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    Hey Ryan, I'm also on this same combination as we discussed previously. I haven't felt this side effect or read that lethargy is a side effect of anti androgens. However, what I do know is when I first used RU about six months ago I read that heart problems were a side effect. It was about that time that I felt chest pains. Also, when I started oral minoxidil I *thought* that I was having heart palpitations but these went away.
    What I'm saying is that it could be psychosomatic. I restarted RU and I have since not felt any chest pains and additionally when I was not using RU I felt chest pains but of course didn't attribute them to RU. If you are worried you could switch to CB at the same dosage, I have found them to be similar in effectiveness though it is too early to say with any certainty. I guess it would be a shame to drop topical AAs if you feel they are working
     
  4. ryan r

    ryan r Established Member

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    Yeah I had a lot of things going on that can cause fatigue. I am starting to feel better. If I can keep this up I am gonna start with RU again. I don't think it caused the fatigue to be honest. But I am gonna wait for a couple more days. I really want to keep using it!

    Thanks for the advice!

    I will report my findings here....
     
    #4 ryan r, Apr 22, 2020
    Last edited: Apr 22, 2020
  5. Ausgebombt

    Ausgebombt Established Member My Regimen

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    I’ve been on 30 mg RU for the past 7 weeks and it’s done absolutely nothing to me. Still shedding like a dog.

    how can you objectively measure lethargy during a social isolation lockdown?
     
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  6. ryan r

    ryan r Established Member

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    Jep, there is the lockdown, and there is the fact that I was on meds that were making me tired, plus there is other stuff going on in my life that can cause some serious fatigue issues. My energy is coming back and if it stays there for a couple of days, I will hop back on it.

    Sucks that you keep shedding, but its only been 7 weeks, stick with it for a couple of months until you can make an informed decision.
     
  7. FCKW36

    FCKW36 Experienced Member

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    I also think it's all in your head. I'm taking 140mg RU every day for 6 years straight. When I first read about the myth that RU can cause heart problems I felt chest pain and shortness of breath for several days so that I stopped it for some days. Never had this problems again after clearing up my mind.
     
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  8. Ausgebombt

    Ausgebombt Established Member My Regimen

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    I
    It seems like everybody has a different opinion on this. I’ve heard everything from 10-150 mg working for people. 50 mg worked on the monkeys.
     
  9. baba_yaga

    baba_yaga Experienced Member My Regimen

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    Ru does sh*t
     
  10. Hair-pun

    Hair-pun Established Member My Regimen

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    It's of course very difficult for anyone to say whether a drug will work for you or not because androgenic alopecia is multi-faceted and RU may not be addressing the issue that is causing your loss. However, I would agree that 30mg is a low dose. I needed 50mg to reduce shedding. RU works differently to other anti androgens in that if it works it works quickly. I *think* that I saw a reduction in shedding at about two weeks. To give yourself a good chance to evaluate whether it is working I would do this:
    1) Mix 50mg powder daily (keep refrigerated of course) in 1ml of stemoxidine and immediately apply it to clean dry scalp shortly after showering.
    2) Cut your hair short or part it methodically as you work across the scalp to make sure it is getting to your scalp and not sticking to the hair. 3)Monitor shedding closely for 3 months and see if there is a reduction. If not then you can drop it and continue to keep an eye on shedding- if there is any increase after dropping it then you'll know that it was working and it's worth continuing. If shedding remains the same you could try CB at 50mg per day to see if that works any better.
    It's also worth mentioning that I read that RU has a higher binding affinity than testosterone but not DHT. I don't know if this is true but if it is it would mean that it is only really effective when used in combination with oral finasteride or dutasteride as these crush DHT systemically, but don't address the testosterone attacking follicles locally in the scalp.
     
    #10 Hair-pun, Apr 22, 2020
    Last edited: Apr 22, 2020
  11. Hair-pun

    Hair-pun Established Member My Regimen

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    That's interesting to hear that you have been on RU for 6 years, people often report a loss of effectiveness after a short time. Did you experience this? Also, I'm new to RU and keen not to take any unnecessary health risks- do you have any regular medical checks to make sure it isn't causing any cumulative damage to heart/ arteries?
     
  12. Ausgebombt

    Ausgebombt Established Member My Regimen

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    In the human-graft on mice study they used even less than the monkeys and still grew hair. I think they used like 0.1 mg effective RU dose 5 days per week or something like that. I’ll have the research paper at home I’ll check what the exact value was later.

    Considering the binding affinity of RU is super high over an order of magnitude that of CB, I wouldn’t expect that massive doses are required but of course there are other factors at play.
     
  13. Hair-pun

    Hair-pun Established Member My Regimen

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    Have you used Anagenic's RU? Wondering how they compare to Chemyo or others. I use Wuhan for CB
     
  14. FCKW36

    FCKW36 Experienced Member

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    I don't really know how effective it is. When I started treatment 6 years ago with minoxidil, I got massive regrowth, but now I'm beyond baseline. But without RU or minoxidil I would be slick bald by now.

    No I don't have regular check ups. Had a lot of blood work down recently because I had an operation because of a tonsillar abscess and everything was fine even liver and so on.
     
  15. Hair-pun

    Hair-pun Established Member My Regimen

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    Thanks for this reassurance- I'm probably just being paranoid! Great to hear that you have more than maintained on this combo!
     
  16. FCKW36

    FCKW36 Experienced Member

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    No worries, being sceptical has nothing to do with being paranoid. We are talking about a research compoind which is produced in Chinese backyard laboratory. But from my experience it's well tolerated. I have absolutely no side effects.
     
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  17. Ausgebombt

    Ausgebombt Established Member My Regimen

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    If you have some science ability and about $800, you can purchase the equipment to test RU beyond reasonable doubt. Look into a UV-Vis spectroscopy, thin layer chromatography, and melting point tests. Then cross reference your results with the RU scientific literature.
     
    #17 Ausgebombt, Apr 22, 2020
    Last edited: Apr 22, 2020
  18. ryan r

    ryan r Established Member

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    I am back on it. I don't know what caused the extreme fatigue. I know for a fact that the fatigue wasn't in my head, but did RU cause it? Lets hope not. I really need something besides RU to keep my hair in the long term. Using both RU and dutasteride seems like an amazing combo to me.

    BTW I am only using a 3 percent solution, I see people talking here about effective dosage, I drop 1ml of liquid on my scalp. Thoughts?
     
  19. Hair-pun

    Hair-pun Established Member My Regimen

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    I'm guessing it's different for everyone but I didn't see a decent reduction in shedding until i hit 5% and it seems that 5% of 1ml is pretty standard for most people. Worked up from 2%. If anything changes my next step will be twice a day i think
     
    ryan r likes this.
  20. ryan r

    ryan r Established Member

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    I am quitting again...I just cant seem to handle it....Maybe I will try again in a couple of months but for now I need my sleep and my energy.
     

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