RIKEN Announcement: Succeeded in Developing Tech for HF Regenerative Medicine: Study to be Published Feb 10

[werefckd]

Ok in a more serious tone. I'm happy Tsuji san is still trying. But he obviously got huge setbacks and now is trying a fresh start with some discoveries he had in vitro. Although I don't see it as adequate all that fuss about press conference and embargo just to announce that kind of study.

My comments are more directed at Pegasus that was denying the fact that Organ went under because the research reached a dead end, and was predicting that everything went right and that they were going to show us the first cloned hair in a human.

I'm sick of these fairy tales stories. If something doesn't sound right then it probably isn't.

 

[1919]

Let's rationalize for a moment:
2 days ago we were all convinced Tsuji's research had failed and stopped.
Now they publish a study with the longest cloned hair i've ever seen.
If the translation is correct, and the next stop is actually clinical studies, considering how easy it is in japan to get approval for stem cell therapies (they've approved a spinal chord threatment with only 13 participants, not double blinded and with no clear signs of efficacy), this could be available realistically in a couple of years.
I think today is a great day

Agreed. But id put a longer time stamp on it just to save some tears.

 

[Gegen]

I don't understand what should be negative about it?

Nothing really negative. Just the hype that is coming down after ( once again ) huge expectations.

 

[werefckd]

Let's rationalize for a moment:
2 days ago we were all convinced Tsuji's research had failed and stopped.
Now they publish a study with the longest cloned hair i've ever seen.
If the translation is correct, and the next stop is actually clinical studies, considering how easy it is in japan to get approval for stem cell therapies (they've approved a spinal chord threatment with only 13 participants, not double blinded and with no clear signs of efficacy), this could be available realistically in a couple of years.
I think today is a great day

P.S. We don't even have the knowledge to really understand if and how much of a breakthrough this study is.

Tsuji research indeed failed and stoped. And now they did some in vitro studies and are trying to start again. Good. But it's basically confirmation that they are many years behind now because of what happened at Organ.

 

[frank33]

Ok in a more serious tone. I'm happy Tsuji san is still trying. But he obviously got huge setbacks and now is trying a fresh start with some discoveries he had in vitro. Although I don't see it as adequate all that fuss about press conference and embargo just to announce that kind of study.

My comments are more directed at Pegasus that was denying the fact that Organ went under because the research reached a dead end, and was predicting that everything went right and that they were going to show us the first cloned hair in a human.

I'm sick of these fairy tales stories. If something doesn't sound right then it probably isn't.

I agree with you about Pegasus, but this study shows in vivo results, not in vitro.

 

[werefckd]

Also, we don't know if Tsuji is really going to try to partner with a company again, rise funds again, do all that stuff necessary to commercially release hair cloning in the market, OR is just hyping some in vitro studies to be relevant in the media again

 

[1919]

Thats fine to have a difference of opinion, its normal. But the way you reacted was extremely strange pal - you must realise that reading your comments back, right?

Im pretty sure he was f*****g around.

 

[frank33]

Agreed. But id put a longer time stamp on it just to save some tears.

That's right.

Impossible this will get on the market in 5 years imo and even if that optimistical scenario would occur, it's going to be expensive as hell.

You could be right, but as i've said i'm assuming their next stop actually is clinical studies, so every prediction is based on that assumption.

Also, we don't know if Tsuji is really going to try to partner with a company again, rise funds again, do all that stuff necessary to commercially release hair cloning in the market, OR is just hyping some in vitro studies to be relevant in the media again

In vivo, not vitro!

 

[werefckd]

I agree with you about Pegasus, but this study shows in vivo results, not in vitro.

A collaborative research group consisting of Takashi Tsuji, team leader of the Organ Induction Research Team, RIKEN Center for Biofunctional Science, and Makoto Takeo, a senior researcher, has more than 100 times more hair follicle stem cells in vitro while maintaining hair follicle regeneration ability. We established a culture method to amplify and clarified the stem cell population required for periodic hair follicle regeneration over a long period of time.

The results of this research are expected to contribute to basic research such as developmental biology and to realize hair follicle regenerative medicine, which is next-generation organ regenerative medicine.

---
I didn't see anything about them trying it in vivo.

Basically they are claiming to have solved something but haven't even tested it in a living being!

This is weaker than a study in mice!

 

[werefckd]

but I would have liked a more detailed statement from Tsuji. Sometimes they are already mysterious. As if one had to interpret verses of the Koran. Just say how it goes from now on

They are "mysterious" because they don't have anything more interesting to show

 

[jan_miezda]

so this is the first hair follicle regeneration from completely human cells. Stemson didn’t even use humanEC

 

[frank33]

A collaborative research group consisting of Takashi Tsuji, team leader of the Organ Induction Research Team, RIKEN Center for Biofunctional Science, and Makoto Takeo, a senior researcher, has more than 100 times more hair follicle stem cells in vitro while maintaining hair follicle regeneration ability. We established a culture method to amplify and clarified the stem cell population required for periodic hair follicle regeneration over a long period of time.

The results of this research are expected to contribute to basic research such as developmental biology and to realize hair follicle regenerative medicine, which is next-generation organ regenerative medicine.

---
I didn't see anything about them trying it in vivo.

Basically they are claiming to have solved something but haven't even tested it in a living being!

This is weaker than a study in mice!

Are you blind? That study is literally full of pictures of hair growing in mice!

Stem cells are multiplied IN VITRO, then implanted IN VIVO.

 

[1919]

If they started trials in 2021 and its successful it could theoretically be drip commercialised by 2022/2023. But yes, that would be the very best case scenario and it would most likely be very expensive.

It's all speculation though, may as well just get on with life and see what develops.

I imagine Rooney getting to die with a full head of hair after chasing it his whole life

 

[werefckd]

Dude, please stop assuming and spreading FUD.

You clearly do not have a background in this, research stops and stars all the time. That doesn't it's failed.

It's okay to give your opinion, but you are presenting your opinions as a fact. It's ludicrous.

Dude wake up and smell the coffee. I'm just stating what happened. Why do you think Organ went under??? Come on I'm getting tired of having to argument the obvious here.

 

[Pls_NW-1]

what do you think, when do the studies start?

5 years!

 

[jan_miezda]

what do you think, when do the studies start?

I think this is really good news. This was a part they were stuck with and they developed the tech in November to help them proliferate EC. Now 3 months later they already made follicles.

 

[jan_miezda]

I think this is a clear indication that clinical trials will start in 2021. This is big news. Finally they have the tools to differentiate and maintain EC that work in organogenesis of hair follicle and DPC and it worked in mice. They said there are different type of EC so it’s good news . They already had problems win hair “regenerating” and cycling and now they said it’s fixed

 

[werefckd]

Jesus, they're multiplied in vitro.. thats the only way. They show you pictures of the hairs in mice.. do you need them to spell it out for you?

Yea, they used a mouse later. I stand corrected.

 

[1919]

THEY ARE READY FOR CLINICAL TRIALS!!!!!!

移植後も「生え替わる髪」期待　理研、臨床で実用化へ

理化学研究所などの研究チームは１０日、マウスから採取した毛のもとになる細胞を培養して大量に増やし、マウスの皮膚に移植して周期的に生え替わらせる再生技術を開発した...

news.goo.ne.jp

was posted on Twitter by Riken

This would mean that yadonkey was right!

 

[werefckd]

Im pretty sure he was f*****g around.

lol some people take this board too seriously