Another thing, when you take Bicalutamide, you won't be in need to take estrogens, as bicalutamide increases your sex hormones, but stops androgen/male hormones to work in the body. I do wonder what the health-related effects are of androgen deprivation therapy. Some studies show it as a "Quality of Life; drug", and some say it is hepatotoxic or even, it can hurt the heart. Tho, I do think that Bicalutamide is safe, due to it's low binding affinity. The blockage of the AR signaling by Bicalutamide depends on the concentration of itself and the concentration of androgens. Peripheral tissues (skin, outer regions) have lesser androgen concentration, as like the testicles, bones or muscles. No wonder why Bicalutamide has no effect on testicles, bones and muscles.
BUT I ALARM YOU! This drug is taken for advanced prostate cancer patients, who don't have to choose, because their lives depends on it!
I don't have the permission to give medical advice, nor others. Keep your own research and evaluate between risk-benefit scale.