i have insider info , a friend of a friend of an admin in italian forums who knows someone that works for almirall.
JK , i just assumed they ll need 5-6 months more for results+ a year or less to start production .
P-3074 (polichem Topical Finasteride) Phase Iii Just Ended.
- Thread starter fuDHTck
- Start date
JK , i just assumed they ll need 5-6 months more for results+ a year or less to start production .
br1
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their "promise" is to deliver a finasteride that won't go systemic. that (if possible) would be something interesting.
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A molecule that moulder after a certain time, or helped by a specific vehicle, to reduce scalp DHT and limit collateral damages in serum level.
Basically reduce DHT level only on scalp bloodstream.
In case of P-3074
Results: Change from baseline in scalp DHT was -70% for P-3074 o.d. and approx. -50% for P-3074 b.i.d. and the tablet. Serum DHT decreased by 60 - 70%. The doses of 100 and 200 μL P-3074 resulted in a -47/-52% scalp DHT reduction, similar to the 300 and 400 μL doses (i.e., -37/-54%). A -5.6% inhibition was observed for the vehicle. Serum DHT was reduced by only -24/-26% with 100 and 200 μL P-3074 and by -44/-48% with 300 and 400 μL P-3074. No relevant changes occurred for serum testosterone.
https://www.researchgate.net/public...one_in_healthy_men_with_androgenetic_alopecia
Very poor results if you ask me
br1
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AFAIK DHT is produced by the body in the areas where it is used. So, it is produced in the tests and in the scalp(?). If so, by applying finasteride on the scalp and having it blocking the 5a-r enzyme only there, the patient would not suffer sexual sides but still block the DHT (in the scalp only).
that is i believe the most important point of p3074 phase 3 , to evaluate with a double blind study if dht which is considered to be a pararine hormone (acting topically ) at least for the prostate ,acts the same way for the scalp , and how much the bloodstream levels of dht damage your hair
(Of course provided that they can replicate the phase 2 results for dht levels )
how is that poor ? tablet inhibits 50 % scalp dht and 70 % serum , p3074 low dose inhibits ~ 50 % scalp and 25 % serum
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Nope DHT is also produced in the skin, hair follicle, liver, brain...by the 5ar-reductase
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Thus, DHT should be thought of as a paracrine hormone formed and acting primarily in target tissues. 3 alpha androstanediol glucuronide (3 alpha diol G) is a major metabolite of DHT. An important site of its formation is the skin
(https://www.ncbi.nlm.nih.gov/pubmed/1551803 )
well the same study concluded that oral finasteride only inhibits 50 % of scalp dht , and high dose topical finasteride 70 % of scalp dht . So either there was some statistical error from the real value of oral finasteride , or it indicates that topically it should work better in high doses ( w/o limiting sides ofc at these doses )
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Old, but gold
The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia.
https://www.ncbi.nlm.nih.gov/pubmed/10495374
The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia.
https://www.ncbi.nlm.nih.gov/pubmed/10495374
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Anyway, whatever to limit those sides
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If those dht serum levels are from scalp absorption, then I will stop eating with my mouth and just blend my food and put it on my scalp.
They are probably mostly from the prostate
Since you need 5 years of fda testing what do you expect ? if you invent a drug tomorrow it will still take 5-6 years to come the market
They 've been in phase 3 since 2015, so should be more than 5+ year. They are testing, we are dying.
Btw, 20+ years and no such new treatment invented. Only starting from 2015 (maybe), a lot of new "promising" treatment. Did they just realize that the balding industry is a cash cow industry ?