My Zix Experience - How B6 And Zinc Have Saved My Hair

smoothbrain

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anyone try melatonin yet? i cant find the actual mg to put in a solution. I think its 0.1% melatonin solution, but how many mg would that be for say 2oz? I have Premier research lab liquid melatonin that has 8mg per dropper (1ml), but not really sure on the right math.
I found they used 1ml of .1% alcohol solution of melatonin per application. So if my math is correct they used 1mg per application. Maybe I'll just add that each time I apply the zix.
 

fugged

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Not sure you want to mix melatonin in zix as it’s a chemistry experiment you can’t realistically track- some of us are already adding Argenine which is also experimental. The ionic zinc might be a good idea, but you’d have to try it and get back to us. Melatonin sounds promising, but I’m not sure how many topicals can be used since they may react or whatever with one another- as I recall there is some research behind it but you’d have to do the math on dosage, and also make sure, or at least consider how stable it is in your solution once diluted. I don’t think you need much. For sleep most supplements are way too high a dosage apparently with melatonin.
 

smoothbrain

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Not sure you want to mix melatonin in zix as it’s a chemistry experiment you can’t realistically track- some of us are already adding Argenine which is also experimental. The ionic zinc might be a good idea, but you’d have to try it and get back to us. Melatonin sounds promising, but I’m not sure how many topicals can be used since they may react or whatever with one another- as I recall there is some research behind it but you’d have to do the math on dosage, and also make sure, or at least consider how stable it is in your solution once diluted. I don’t think you need much. For sleep most supplements are way too high a dosage apparently with melatonin.
If my math is correct, they used 1mg melatonin per application. I have a liquid melatonin by premier research and 4 drops is equivalent to 1mg. If I end up using it with zix I would just add 4 drops each time when I apply it.
 

fugged

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My recollection from something I read a while back is you could use way less. Have you searched the literature? There is a paper or two.
 

Yagel

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I have bought the Zinc Arginine Study https://pubmed.ncbi.nlm.nih.gov/33878855/
and the results are pretty good. Apparently the Lotion consisting of Zinc-Gluconate and Arginine was as good as Finasteride after 6 months. However I think the dosages are very important and the study doesn't tell them.

They just say that the combination of 0,04% Zinc-Gluconate and Arginine caused a 75% Reduction in 5-Alpha Reductase in-vitro.
 

Pigeon

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I have bought the Zinc Arginine Study https://pubmed.ncbi.nlm.nih.gov/33878855/
and the results are pretty good. Apparently the Lotion consisting of Zinc-Gluconate and Arginine was as good as Finasteride after 6 months. However I think the dosages are very important and the study doesn't tell them.

They just say that the combination of 0,04% Zinc-Gluconate and Arginine caused a 75% Reduction in 5-Alpha Reductase in-vitro.
They also had an in vivo test right?

"We also performed an in-vivo study."

Did they say anything about that. Or could you post the most important parts of the study here please.

Edit: also very interesting they use zinc-gluconate, that's what is used in most zinc supplements. So basically confirms what most people already thought, no need for zinc sulfate heptahydrate. @worm
 

fugged

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They also had an in vivo test right?

"We also performed an in-vivo study."

Did they say anything about that. Or could you post the most important parts of the study here please.

Edit: also very interesting they use zinc-gluconate, that's what is used in most zinc supplements. So basically confirms what most people already thought, no need for zinc sulfate heptahydrate. @worm
Pigeon how do you measure your arginine? I empty capsules of zinc and basically fill and empty three of those…
 

Pigeon

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Pigeon how do you measure your arginine? I empty capsules of zinc and basically fill and empty three of those…
I use L-arginine supplements that are already in capsules so I know how much is in each one.
 

fugged

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Hmm I got “pure” powder, weren’t you worried about the extra ingredients like corn starch etc? It may be nothing but over the days it would almost certainly start to change in solution I’d imagine.
 

Pigeon

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Hmm I got “pure” powder, weren’t you worried about the extra ingredients like corn starch etc? It may be nothing but over the days it would almost certainly start to change in solution I’d imagine.
Yeah, pure is much better but so far it seems okay. I also make a new batch every 2-3 weeks.
 

Yagel

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They also had an in vivo test right?

"We also performed an in-vivo study."

Did they say anything about that. Or could you post the most important parts of the study here please.

Edit: also very interesting they use zinc-gluconate, that's what is used in most zinc supplements. So basically confirms what most people already thought, no need for zinc sulfate heptahydrate. @worm
Yes they did. They had 20 participants taking the Lotion with Zinc and Arginine and 20 with placebo.
Mean Hair Count improved by 52% after 6 months. These results are on the same level as finasteride.
They did not provide any photographs.

Unfortunately they did not tell the dosages of the ingredients.

It is also important to note, that some of the patients had telogen effluvium and not Androgenetic Alopecia.
 

EndlessPossibilities

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Yes they did. They had 20 participants taking the Lotion with Zinc and Arginine and 20 with placebo.
Mean Hair Count improved by 52% after 6 months. These results are on the same level as finasteride.
They did not provide any photographs.

Unfortunately they did not tell the dosages of the ingredients.

It is also important to note, that some of the patients had telogen effluvium and not Androgenetic Alopecia.
No photos. What a bust. f*****g scientist. I cant beleive they database published them. The standards for getting published need to go up. Way way up.
 

smoothbrain

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Edit: also very interesting they use zinc-gluconate, that's what is used in most zinc supplements. So basically confirms what most people already thought, no need for zinc sulfate heptahydrate. @worm
I read some study linked here that tested like 4 forms of zinc. It said they all worked, but zinc sulfate was less irritating than the others. I know many hair loss shampoos use zinc chloride, which is the more irritating form, but may not matter if your rinsing it off.

My recollection from something I read a while back is you could use way less. Have you searched the literature? There is a paper or two.
They used a .1% solution of melatonin In alcohol per 1ml each application. So my maths came up with 1mg per application.
 

smoothbrain

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I feel like the arginine helps only because it's a vasodilator. So it basically just increases circulation. I think there's many things things that can do that like scalp massages or tipping your head in a downward slope. I use some herbal oil on the scalp that I massage and leave on for 20 min before shampooing.
 

Yagel

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I feel like the arginine helps only because it's a vasodilator. So it basically just increases circulation. I think there's many things things that can do that like scalp massages or tipping your head in a downward slope. I use some herbal oil on the scalp that I massage and leave on for 20 min before shampooing.
According to the study, arginine is an inhibitor of 5-alpha-reductase aswell. But I think the problem is the dosage. Unfornately the study only provides the ingriedients of the Lotion and not the dosages.

I have tried to contact the author of the study, but I don't speak italian and the secretary of his Institute doesn't speak english.
 

fugged

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Thanks for trying! Maybe we need a translated email. Unfortunately they probably want to keep it proprietary. Can we glean anything from the previous study that involved arginine? There was a second study correct?
 

smoothbrain

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I just made my zix and I'm leaving it out for a night to dissolve more fully, but I'm considering leaving out the sediment when pouring the solution into bottles. I used a liquid zinc and the pure formulas b6 powder. I'm thinking the sediment is just fillers not actual b6.

The reason I think so is because I have used liquid b vitamins before and one 1oz bottle had 150mg b6 p5p total and I don't remember sediment.

Anyone ever buy pure p5p in powder form from bulk supplements or something and try to make zix? Did you still have sediment?
 

Myco.1934

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According to the study, arginine is an inhibitor of 5-alpha-reductase aswell. But I think the problem is the dosage. Unfornately the study only provides the ingriedients of the Lotion and not the dosages.

I have tried to contact the author of the study, but I don't speak italian and the secretary of his Institute doesn't speak english.
Can you try to translate your message into italian with google translate?
Thank you for sharing the article with us.
 
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