BiqqieSmalls
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They probably made it a pill so that way it could be implemented into the big three regimen and wouldn't take the place of minoxidil. I'd like Hellhouser's opinion though.
Kythera Acquires Rights to PGD2 Inhibitor
- Thread starter hellouser
- Start date
They probably made it a pill so that way it could be implemented into the big three regimen and wouldn't take the place of minoxidil. I'd like Hellhouser's opinion though.
bushbush
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With cetirizine people were completely stabbing in the dark on delivery method, dosage, and timing of application.
While the idea is the similar (and originated from early publications in this very same work), this compound, tested in a systematic and scientific way, is much more promising.
While the idea is the similar (and originated from early publications in this very same work), this compound, tested in a systematic and scientific way, is much more promising.
bushbush
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Reversal would be ideal, but this could still be of great benefit even without, especially given that it is looking more and more likely that hair cloning treatments will also require a co-therapy to maintain (and preferably one without sexual side effects).
I think this will be more preventive, maintaining drug.
I experimented with cet. (orally and topically) 5-15mg ED. Nothing drastic happened.
BiqqieSmalls
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From what I understand, Setipiprant completed Phase III trials for asthma. Is this correct?
Would they have to start at Phase I trials for male pattern baldness? Their next steps are to open an IND for Setipiprant. Correct me if I am wrong, but an IND means an Investigational New Drug, which alludes to Kythera having to start from the beginning of Phase I trials. I hope I am wrong
Couldn't doctors prescribe Setipiprant off-label for male pattern baldness when it gets approved by the FDA for asthma?
Would they have to start at Phase I trials for male pattern baldness? Their next steps are to open an IND for Setipiprant. Correct me if I am wrong, but an IND means an Investigational New Drug, which alludes to Kythera having to start from the beginning of Phase I trials. I hope I am wrong
Couldn't doctors prescribe Setipiprant off-label for male pattern baldness when it gets approved by the FDA for asthma?
From what I understand, Setipiprant completed Phase III trials for asthma. Is this correct?
Would they have to start at Phase I trials for male pattern baldness? Their next steps are to open an IND for Setipiprant. Correct me if I am wrong, but an IND means an Investigational New Drug, which alludes to Kythera having to start from the beginning of Phase I trials. I hope I am wrong
Couldn't doctors prescribe Setipiprant off-label for male pattern baldness when it gets approved by the FDA for asthma?
I think YES, but it might skip some safety trials.
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Why would it need to be '100X more powerful than cetirizine' ?? Not all AAs work the same. Take Saw Palmetto versus Finasteride or Dutasteride. All three have varying degrees of strength and dutasteride being the 'strongest' but working different than the other two anyway. Keep in mind cet likely never worked because it didnt target the receptors at the follicle, which SET *has to* if Dr. Cotsarelis gave the green light on.
Not all PGD2 inhibitors will be or are the same, hence why they didnt just randomly select a drug from the list of them that Cotsarelis had in mind to tackle hair loss.
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From what I understand, Setipiprant completed Phase III trials for asthma. Is this correct?
Would they have to start at Phase I trials for male pattern baldness? Their next steps are to open an IND for Setipiprant. Correct me if I am wrong, but an IND means an Investigational New Drug, which alludes to Kythera having to start from the beginning of Phase I trials. I hope I am wrong
Couldn't doctors prescribe Setipiprant off-label for male pattern baldness when it gets approved by the FDA for asthma?
From the presentation they gave, yes, they clearly stated they can jump straight into Phase 2A trials. SET has already undergone 8 clinical trials, so theres no reason to test safety anymore.
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Doubt it. If its more effective orally, then they'll do it that way. Finasteride can be mixed into a topical formulation, and its been done before, but we all know it doesnt do sh!t for halting DHT unless it goes systemic, therefor, oral is the ONLY route finasteride can be taken.
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Just a heads up, I think you guys should start requesting that Spencer Kobren tries to get Dr. Cotsarelis on the show to talk about the news about PGD2 and/or perhaps Keith Leonard from Kythera (CEO). Perhaps we could ask questions like:
- What will the dosages be trialed at?
- What is the half life of the drug?
- Any chance of a faster release outside of USA?
etc.
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This is the link:
http://www.keyorganics.net/bionet/setipiprant-mfcd23136043-c24h19fn2o3-1.html
Too expensive for most especially if it requires more than 1mg per day.
BiqqieSmalls
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I think this is a good idea. Any other questions?
Hairismylife
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Economies of scale dude. That's not going to be price for consumer after its mass produced, lol.
Hairismylife
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So we should organize a group buy asap.
But we still dunno the "novel" delivery method in the patent. I just dont wanna wait for its official commercialization which is likely 2~3 years away.
K
karankaran
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Sounds like great news. Awesome.
0-100realquick
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Sounds promising, but when do they "think" it will be released to public in the United States and Canada?
BiqqieSmalls
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If I had to guess, about 1.5 years in Phase II and 2 years in Phase III. So 4-5 years max?
0-100realquick
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Ah alas, the good ol "4-5 years". That's what they always say. I hope you are right.