Kintor has started Phase 3 trial in China for Pyrilutamide

[hairboy12345]

Yeah those placebo results are weird af????

 

[pegasus2]

So we need 20mg a day of this stuff versus 200mg of RU

 

[Redgate]

It's most likely that placebo is high because people are on minoxidil and finasteride. I wouldn't stop other treatments even if I wasn't in the placebo group.

 

[Intrigued77777777]

It's most likely that placebo is high because people are on minoxidil and finasteride. I wouldn't stop other treatments even if I wasn't in the placebo group.

Surely it's a controlled trial?? How can you test a hairloss drug if the subjects are taking other hairloss drugs??

 

[JohnDoe5]

It's most likely that placebo is high because people are on minoxidil and finasteride. I wouldn't stop other treatments even if I wasn't in the placebo group.

I really doubt that.

 

[Dr sanches]

It's most likely that placebo is high because people are on minoxidil and finasteride. I wouldn't stop other treatments even if I wasn't in the placebo group.

Retarded statement it says in the study criteria no treatments before

 

[Redgate]

Retarded statement it says in the study criteria no treatments before

Every study criteria says this, no one checks.

 

[Nebula74]

Here is the results, I found them on reddit what's weird to me is that N @ 24 weeks is a lot lower than N at the start, I wonder why that is

 

[hairboy123]

Here is the results, I found them on reddit what's weird to me is that N @ 24 weeks is a lot lower than N at the start, I wonder why that is

Damn straight!!!!! Could it be that they also had 60 users on QD not BID? I’m so f*****g excited

 

[Nebula74]

Damn straight!!!!! Could it be that they also had 60 users on QD not BID? I’m so f*****g excited

Yes I need to get my hands on it fast, only thing is I hope they didn't drop out due to sides, but QD makes sense

 

[hairboy123]

Yes I need to get my hands on it fast, only thing is I hope they didn't drop out due to sides, but QD makes sense

Also helps make sense of the placebo result assuming there was 30 of them too. The ones who were losing a lot would have dropped out?

 

[Nebula74]

Also helps make sense of the placebo result assuming there was 30 of them too. The ones who were losing a lot would have dropped out?

Yeah, I think that would've made sense that 0 or so might drop out from placebo, and then if you account for another ~30 that would've taken it QD, then that adds up to 120, with four treatment groups, good deduction lol

 

[Dr sanches]

Every study criteria says this, no one checks.

Pretty easy to check if they saw your dht was in the gutter via blood tests they would know you are on finasteride and finasteride stays in the blood for months

 

[Nebula74]

I still do not understand why breezula did so well initially and then so poorly when other anti androgens like finasteride or dutasteride really start to show the best results after 12-15 months. its strange because anti androgens take a long time to show their positive effects however with this one it seems to be potent initially and then diminish(breezula). personally I am hopeful that Pyrilutamide does not have this property

I think it might have something to do with the MOA too, as we know how hair becomes more sensitive to androgens over time, so maybe AR blockers require increased dosages over time to block the same amount of androgens, whereas 5aris significantly DHT production, and therefore do a better job at solving the issue at its root, if you discount for side effects

 

[Dr sanches]

I think it might have something to do with the MOA too, as we know how hair becomes more sensitive to androgens over time, so maybe AR blockers require increased dosages over time to block the same amount of androgens, whereas 5aris significantly DHT production, and therefore do a better job at solving the issue at its root, if you discount for side effects

No this isn’t the reason the reason breezula doesn’t do well is it because it’s binding affinity is low . Ru literally had a 70 Times higher binding affinity both ru and breezula don’t compete for dht as well as pyri

 

[oddmood]

There is a disease called androgen insensitive syndrome where androgen receptors are partially or completely insensitive to androgens and there are still reports of certain types of alopecia. So, maybe androgens are just a piece of the puzzle

https://sci-hub.se/10.1111/ijd.13100

https://sci-hub.se/https://doi.org/10.1111/j.1365-2133.2010.09661.x

 

[Znx]

Whats QD guys?

 

[Kagaho]

There is a disease called androgen insensitive syndrome where androgen receptors are partially or completely insensitive to androgens and there are still reports of certain types of alopecia. So, maybe androgens are just a piece of the puzzle

https://sci-hub.se/10.1111/ijd.13100

https://sci-hub.se/https://doi.org/10.1111/j.1365-2133.2010.09661.x

Thats an exceptional case of scarring alopecia, a non androgen form of hairloss.

 

[fran15]

Whats QD guys?

Once a day. BID is twice a day.

 

[Diffused_confidence]

Placebo at nearly 10 hairs? Sorry but this drug is worthless. Epic fail by kintor. These results look identical to breezula. And if the results were a 6 month trial then it will probably lose efficacy like breezula did after 12.