Kintor has started Phase 3 trial in China for Pyrilutamide

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Nebula74

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Diffused_confidence said:
Minoxidil is barely helpful at stopping hair loss. If this just is just as effective as minoxidil then why not use minoxidil? When you look at the finasteride and dutasteride studies, hair counts went DOWN for the placebo.

It's a tough pill to swallow but kintor is not the answer. Complete failure, as usual
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because not everyone responds to minoxidil due to the enzyme not activating in the scalp. this has a different moa to min as it blocks the ar so you'd assume the results would be more long term than min, anyway 11 people dropped out of placebo so you'd assume their hair was getting worse, anyway here is a finasteride study where placebo increased



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5minutesbeforemiracle

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Diffused_confidence said:
Minoxidil is barely helpful at stopping hair loss. If this just is just as effective as minoxidil then why not use minoxidil? When you look at the finasteride and dutasteride studies, hair counts went DOWN for the placebo.

It's a tough pill to swallow but kintor is not the answer. Complete failure, as usual
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Why are you judging a product based on how the placebo performed?
 
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Anatman

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5minutesbeforemiracle said:
Why are you judging a product based on how the placebo performed?
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because you want a comparison: you want to know to what extent the remedy is helpful in relation to no treatment (placebo). Since we know that hair loss is a b**ch, we assume that the hair loss will progress, i.e. the result with placebo will be worse. here, however, it has increased significantly, which is unusual and of course also makes the end result worse or more unreasonable overall. The success of KX would have been clearer if the placebo group had not had an improvement. Also, it's questionable why they had any improvement: seasonal shedding, continued use of other treatments (have heard from a few at Tressless who were convinced they were in a placebo group and therefore switched to finasteride etc.) or whatever. it remains unclear, I would say.
 
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5minutesbeforemiracle

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Anatman said:
because you want a comparison: you want to know to what extent the remedy is helpful in relation to no treatment (placebo). Since we know that hair loss is a b**ch, we assume that the hair loss will progress, i.e. the result with placebo will be worse. here, however, it has increased significantly, which is unusual and of course also makes the end result worse or more unreasonable overall. The success of KX would have been clearer if the placebo group had not had an improvement. Also, it's questionable why they had any improvement: seasonal shedding, continued use of other treatments (have heard from a few at Tressless who were convinced they were in a placebo group and therefore switched to finasteride etc.) or whatever. it remains unclear, I would say.
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Yep, I agree with what you wrote. On top of the confounding factors you mentioned, it also looks like quite a few participants in the placebo group actually dropped out of the trial; presumably they noticed their hairloss progressing. Those people dropping out would've raised the average score of the placebo group. But the person I was replying to was saying that Kintor's a "complete failure" because the placebo group improved lmfao.

Btw, you say people on tressless were in the Kintor trial? Wasn't it in China? Of the 19 placebo patients that finished the trial, some of those Chinese people are posting on reddit tressless in English? Sounds sketch to me.
 
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JohnDoe5

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Anatman said:
because you want a comparison: you want to know to what extent the remedy is helpful in relation to no treatment (placebo). Since we know that hair loss is a b**ch, we assume that the hair loss will progress, i.e. the result with placebo will be worse. here, however, it has increased significantly, which is unusual and of course also makes the end result worse or more unreasonable overall. The success of KX would have been clearer if the placebo group had not had an improvement. Also, it's questionable why they had any improvement: seasonal shedding, continued use of other treatments (have heard from a few at Tressless who were convinced they were in a placebo group and therefore switched to finasteride etc.) or whatever. it remains unclear, I would say.
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I also don't see any point to worrying about the placebo group. What matters is the active therapy group.
 
RoryGall29

RoryGall29

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ZLulic said:
No one knows yet. AR upregulation might be a real thing and Kintor didn't want to risk it with 12 months.
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Risk what? If customers find out that it's efficacy goes heavily down after 6 months no one will buy it anymore, what's the point of releasing it in the first place?
 
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pegasus2

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Flamingflaps said:
A year of sales wouldn’t cover development costs… not even close.
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I've seen drugs get approved that will never recoup their development costs lol
 
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Ljames

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Hard_science_only said:
Bad news guys. Kintor has delayed the publication of phase II results again to September 2022.
Unfortunately, really looks like an other scam.
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I don't understand why you would progress to phase 3 and the costs involved in that if you're aware the phase 2 results are lacking
 
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Hard_science_only

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Ljames said:
I don't understand why you would progress to phase 3 and the costs involved in that if you're aware the phase 2 results are lacking
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Probably to keep the stock price elevated till they can raise new funds, management can cash out, other product candidates can progress to more promising stages etc.
 
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