There's also the fact that finasteride doesn't just inhibit 5-alpha reductase type 2. It also inhibits type 3.What a plot twist, he talks negatively about Dutasteride lol because coincidentally 5ar1 is important but 5ar2 can be inhibited by the "extremely safe" drug Finasteride. How coincidental the only enzyme that we have to block to stop hair loss is the enzyme that can be safely inhibited while any other enzymes can cause problems when inhibited.
And recent research has found that finasteride also inhibits 5-beta reductase, which is a different enzyme from the three types of 5-alpha reductase. Interestingly, dutasteride doesn't inhibit this enzyme. See the following studies:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740403/
Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride - Nature Communications
Human steroid 5α-reductase 2 (SRD5A2) is an integral membrane enzyme and catalyzes 5α-reduction of testosterone to dihydrotestosterone. Structural analysis accompanied by computational and mutagenesis studies reveal the mechanisms of catalysis and inhibition by clinically relevant drugs...
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