Folks,
I've been working with a group of biochemists and Nano-medicine scientists. I've been told by experts in the field that the Brotzu lotion has a "low" concentration of the bio actives in the vesicle.
Furthermore, the usual encapsulation efficiency for a liposome is 10-20% of the original active substance, Brotzu mentions he got higher than 80% which makes no sense as a lot of bio active gets lost in the preparation proces with sonication.
The liposome in the patent mentions an "unbelievably" high encapsulation efficiency. Which makes it questionable.
Also, in working with the scientists at the labs, I was informed that liposomal science is undergoing a change in thinking as liposomes don't necessarily transport active drug /cosmetic (eg S-Equol, DGLA and Carnitine) to the skin, it breaks on contact. So these compounds don't get to the skin via liposome, so the next question is , will a topical application allow them to pass the skin barrier?
The following article from research at the University Southern Denmark speaks to it.
I've been working hard to get Broztu's lotion prepared in a proper lab, and I've supplies lined up from the major distributors, but, this entire procedure in his patent is not adding up or making sense when the nano-medicine group that's helping me to reproduce it is not working.
Remember, these people I am working with are professional nano-medicine scientists and liposome manufacturing for pharmaceutical applications is their bread and butter, and this is not their first rodeo. I'm paying a big price tag to keep them engaged to ensure fidelity to the protocol as close as possible.
For once and for all I want to get this lotion produced and tested with proper results and as close adherence to Brotzu's original protocol to debunk or to validate Broztu's claims. Clearly, FIDIA will take eons to respond or validate. So the citizen community activists like myself have taken this up to Valdosta it .
Honestly, in the labs with the biochemists and nano-mediocre scientists reading the procedure, many are doubtful of the science overall.
Don't want to burst anyone's bubble.
@Swoop &
@hellouser, can you guys chime in too ?
Here's the article in news and academic publications :
http://sciencenordic.com/liposomes-skin-creams-don’t-work
Article:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709185/