explanation from Folexen thread:From Brotzus answers, if the quote below is accurate and based on my following, the s-equol would act the much the same as as finasteride by inhibiting the conversion of Testosterone to DHT.
...Efficacy aside, thats exactly what people who've been having finasteride sides (myself included) and looking for something new would not want.
Can anyone chime in who has a better understanding here?
PGE1 improved microcirculation, s-equol stopped 5-α-reductase thus preventing testosterone to turn into dihydrotestosterone and carnitine entered the beta oxidation of lipid chains improving their metabolism.
some user's post:Enzymatic inhibitors have a drawback in that, for some men, the recommended dosage might not be sufficient to deactivate all the 5AR without causing other problems. In other words everyone probably has a dosage level at which the medication will work, but for some people there are too many concomitant side effects for the treatment to be safe. Merck have shown that normal dose Propecia resulted in improvement for 77% of patients . Presumably a different treatment is required for the remaining men.
This is where S-equol can step up to the plate. It has a mode of action that is very different to the 5AR inhibitors. Instead of preventing the production of DHT, it binds strongly to the DHT molecules. When DHT has S-equol attached to it, it is no longer a form of 'free DHT', i.e. it cannot cause male pattern baldness because the molecule is no longer able to bind to receptor sites.
The ability of S-equol to bind to DHT is very strong , which is good news for us. Theoretically there are sufficient levels of S-equol in serum, all the DHT can be mopped-up before it can cause damage, even the DHT that is inside hair follicles. S-equol is a small molecule, not a protein, so it has no problem crossing cell membranes.
Equol binds to DHT directly and changes it chemical form so it doesn't do the damage it would otherwise --- supposedly.....nobody really knows if this is effective for hairloss and the bio-chemical processes that dictate whether hair falls out or not...
finasteride affects the 5aR enzyme that is a catalyst for normal Testosterone conversion to DHT...finasteride limits DHT levels indirectly...but 5aR is an enzyme that does a whole host of other things and screwing with that will screw with you -- like your estrogen levels
So finasteride inhibits 5ar, which is responsible for other functions besides DHT, s-equol only inhibits DHT.