S Foote. said:If as i propose, hair follicle growth is restricted in male pattern baldness by contact inhibition caused by increased pressure in the dermal tissue, this would only have its effect on new anagen follicle growth. During such an increase in pressure, existing already grown anagen follicles are not affected untill the next hair cycle. This would explain why all hair is not lost at the same time, and some follicles can show no change for years. The human scalp hair anagen period can last for years.
In my opinion the normal contact inhibition of follicle growth, and its related pressure factors explain the paradox in male pattern baldness.
We also have to consider that if androgens are "locking down" follicle growth at the follicles genetic level, how can anything that does not effect androgens make any difference? Minoxidil for example.
My theory predicts that anything that reduces scalp fluid pressure in male pattern baldness, will increase hair growth.
Do you think if hardened sebum an contribute on the contact inhibition supossed process?