Thanks for your reply!PGE2 induces tissue regeneration and hair growth. Application of SW033291 blocks the enzyme that reduces PGE2 levels in the scalp, allowing PGE2 levels to increase. This is very positive for hair growth, with little prospect for serious side effects.
So SW033291 inhibits 15-PGDH so levels of PGE1, PGE2 and PGF2a are increased.
PGE1 and PGE2 inhibit collagen production, but I see your point about dermarolling, so the increase of PGE2 should be good.It won't make your skin look like sh*t. PGF2a may not be good for it, but let's not exaggerate. Microneedling increases PGE2, yet microneedling makes skin look better not worse. If PGE2 was so bad for skin then microneedling would make it look like sh*t.
PGF2a is bad for skin according to this:
PGF2 alpha & Its Negative Effects
Bimatoprost and Latanoprost are the other two medications which are best studied to induce hair growth by manipulating prostaglandins. They both work as PGF2 alpha analogs (ref).
These are very powerful medications which have been used cosmetically to increase eyelash length, and people have used them topically as well on the scalp to promote hair growth. They are proven as effective for both. (ref)
Unfortunately, these medications when used around the eye have been shown to induce atrophy of both the muscles and fat in the area, leading to sunken, old, wrinkled looking eyes. You can review pics of this well known phenomenon here.
This horrible side effect is due to "fatty degeneration and reduced collagen fibers in the [eye muscles] caused by the prostaglandin or prostamide analogs." (ref) Such changes may be "irreversible" (ref).
So yet again, we have wonderful proven medications that can promote hair growth through manipulation of prostaglandins, but in doing so, they are trashing our collagen and causing our natural facial fat to atrophy and wither away making us look old.
But the effects can be counterbalanced by PGE1 and PGE2 increase, so it is difficult to estimate SW033291 safety.
But now I have a question, instead of SW033291, it would not be simpler and safer to use directly PGE2 as @westonci did?