We now have access to a small molecule, potent inhibitor of 15-PGDH which metabolizes PGE1, PGE2 and PGF2a. It's called SW033291, and is available for purchase here. 15-PGDH is less active against PGD2, but for best effect you would combine this with a potent PGD2 inhibitor like ramatroban, TM30089, or OC000459. Combine these with exogenous PGE2, and you have the ultimate prostglandin protocol. Even better would be dimethyl PGE2, which is more stable and metabolism-resistant. A topical dose of .1% SW033291 should be effective. Here is the patent for SW033291. The above chart shows the levels of PGE2 in A549 cells treated with IL1B and a 15-PGDH inhibitor. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580352/ PGE2 is most commonly used to induce labor. This study evaluated the effect of combining PGE2 and SW033291 on delivery times.