Inhibiting 15-pgdh: Taking The Prostglandin Protocol To The Next Level | HairLossTalk Forums
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Inhibiting 15-pgdh: Taking The Prostglandin Protocol To The Next Level

Discussion in 'New Research, Studies, and Technologies' started by pegasus2, Jun 29, 2020.

  1. pegasus2

    pegasus2 Senior Member My Regimen

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    We now have access to a small molecule, potent inhibitor of 15-PGDH which metabolizes PGE1, PGE2 and PGF2a. It's called SW033291, and is available for purchase here. 15-PGDH is less active against PGD2, but for best effect you would combine this with a potent PGD2 inhibitor like ramatroban, TM30089, or OC000459. Combine these with exogenous PGE2, and you have the ultimate prostglandin protocol. Even better would be dimethyl PGE2, which is more stable and metabolism-resistant. A topical dose of .1% SW033291 should be effective.

    Here is the patent for SW033291.

    nihms898386f3.jpg
    The above chart shows the levels of PGE2 in A549 cells treated with IL1B and a 15-PGDH inhibitor.


    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580352/


    PGE2 is most commonly used to induce labor. This study evaluated the effect of combining PGE2 and SW033291 on delivery times.
    delivery.PNG
     
    #1 pegasus2, Jun 29, 2020
    Last edited: Jul 2, 2020
  2. killDHT

    killDHT Established Member My Regimen

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    Thank you!
     
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  3. killDHT

    killDHT Established Member My Regimen

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    This is a good news to me.I am working about it
     
  4. killDHT

    killDHT Established Member My Regimen

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    Is there any safety test on human body?
     
  5. pegasus2

    pegasus2 Senior Member My Regimen

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    Not yet.
     
  6. John Difool

    John Difool Experienced Member My Regimen

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    Can we do a GB on this? Would that matter much to add TM or OC when DHT level in scalp in undetectable?
     
  7. pegasus2

    pegasus2 Senior Member My Regimen

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    If anyone else is interested in a group buy post how much you'd be interested in purchasing.

    I think it might matter. Even with DHT being down there's still some level of PGD2 production, and it might accumulate in the absence of 15-PGDH.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481126/
     
  8. killDHT

    killDHT Established Member My Regimen

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    I live in China, and I contact the manufacturer through social software. However, there is a gram of 3000 yuan, and then the second seller tells us that 10 grams is thousands of yuan, but the second seller is out of stock. I'm more optimistic about this item. I hope the price will drop, and more human experiments will be carried out. We still don't know whether it is stable.
    Cheer up
     

    Attached Files:

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  9. John Difool

    John Difool Experienced Member My Regimen

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    Stability is an issue. Especially during summer and slow shipping thanks to COVID.
     
  10. pegasus2

    pegasus2 Senior Member My Regimen

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    Stability shouldn't be a problem. This particular molecule was chosen as the lead drug candidate for an oral and topical drug, so it has to have shown excellent stability. The other seller seems to be out of stock on everything. I'm pretty confident human trials will be carried out at some point, but it will probably be a few years, and the first trial will likely be for liver repair.
     
  11. Oppenheimer

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    Incredible find my friend
     
  12. killDHT

    killDHT Established Member My Regimen

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    If I remember correctly, sulfadiazine also inhibited the action of this enzyme. Many people in the forum reported positive effects after experimenting with sulfadiazine.
     
  13. FilthyFrancis

    FilthyFrancis Established Member My Regimen

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  14. Throwaway94

    Throwaway94 Established Member My Regimen

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    How effective could a good PG protocol realistically be? Thinking about OC + some form of PGE as my last fight before calling it but I just haven't seen any success stories around
     
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  15. badhabiz

    badhabiz Experienced Member My Regimen

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    it is. hope human tests sustain pge2 as a stand alone cure
     
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  16. pegasus2

    pegasus2 Senior Member My Regimen

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    This guy was on PGE2, setipiprant, and dermarolling, so basically just PGE2+dermarolling since setipiprant doesn't work.

    setis.JPG
     
  17. John Difool

    John Difool Experienced Member My Regimen

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    Seti 1g BID may work ?
     
  18. pegasus2

    pegasus2 Senior Member My Regimen

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    The binding affinity is too weak to outcompete PGD2 for the receptor even at that high dosage. TM is a much better choice.
     
  19. John Difool

    John Difool Experienced Member My Regimen

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    Did Allergan even bother coming back with their trial?
     
  20. pegasus2

    pegasus2 Senior Member My Regimen

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    LowHairLine likes this.

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