If Cb Works As Well As Casseipoea Shows...
- Thread starter Phatalis
- Start date
- Reaction score
- 8
Down for a group buy
- Reaction score
- 4
Also in for a group buy but have zero way of testing it....also is there a way to get this in to the US that doesn't involve creating a fake company as someone previously stated?
Well. I'm gonna do a tiny bit of research on who to buy / how to do this and test it. I think waiting for the results of the last phase test which I saw should be released this month is good. So we have until then.
Anyone in here who reads this is welcome to try to do research for the buy also.
I'm for sure buying some so it'd be good if we can coordinate and get a lot at a discount and tested.
Anyone in here who reads this is welcome to try to do research for the buy also.
I'm for sure buying some so it'd be good if we can coordinate and get a lot at a discount and tested.
I'm in the US myself and live near a university. Maybe I can see if they test / places around me that test.
Need to figure out how customs works and all that as I keep reading about that. If it's a larger batch I guess it's seized?
Regardless I'm gonna figure out a way to get CB. I needs it.
Need to figure out how customs works and all that as I keep reading about that. If it's a larger batch I guess it's seized?
Regardless I'm gonna figure out a way to get CB. I needs it.
- Reaction score
- 4
Same...keep me posted and let's figure something out for a GB if the data released later this month is positive
- Reaction score
- 239
choose ems as carrier. never had anything seized with them.
-Agreed.
-I'll make a bet it will.
-I don't know honestly, something to consider as people keep mentioning it.
-Will do sir and agreed.
-okay, thanks man!!
-That is a bummer man. I'd wager though that if they're doing extensive testing in these phases they are at least aware or this and/or it's not happening. They aren't reporting it, yet. And it sounds like something that would be obvious... so let's see what the year results bring in. I have a feeling a lot of these sides are coming from sh*t batches from random chinese pharms.
dude, let me know if there is a group buy for this.
How ? Under the patent, no pharma would be able to customize it, I guess
Can you give the link for where u read that the results will be posted this month ?
http://www.cassiopea.com/investor-relations/financial-calendar.aspx
Feb 2019. This company is on-time. Love them
Down for a group buy.
What's a good vehicle? @el_duterino mentioned neogenic but holy flying f*** that's like half as expensive as the cb.
What's a good vehicle? @el_duterino mentioned neogenic but holy flying f*** that's like half as expensive as the cb.
Why not follow patent ? Ethanol : PG : Trans
barfacan
Experienced Member
- Reaction score
- 525
Do you have any other high cortisol symptoms? Maybe high blood pressure? How can you be sure that its the CB causing it? Whats your dose/vehicle? Wiki states that Cortexolone is weaker than cortisol, and from what i recall, a replacement dose of cortisol is approximately 40MG taken internally.
I think standard dose ranges from 3-5%, so probably 30-50mg of CB topically, much less Cortexolone is eventually absorbed into the bloodstream ...thinking it shouldn't cause too many problems?
barfacan
Experienced Member
- Reaction score
- 525
There are labs which specialize in identification HPLC, etc
http://snlabs.com/medical-product-testing.html
So this work has already been done by members such as @hilbert (who is the man might I add)
https://patents.google.com/patent/EP3108879A1
That is the patent. And this is what they were using as a vehicle... you can check out the patent it's right there. (At first I felt uneasy copying this but it's literally right there).
Based on the impurity profile, the formulation prepared in Example 4 is more stable than the aqueous formulation of Example 5.
The formulation described in Example 4 was studied in a clinical trial to evaluate its pharmacokinetic profile, safety, and tolerability.
According to the study protocol, 1 ml of the formulation (corresponding to 50 mg of cortexolone-17α-propionate) was applied once a day on study day 1 and then twice daily thereafter on study days 2-28 to the areas of the scalp suffering from alopecia.
As can be seen from the data, cortexolone-17α-propionate permeates skin about 3 times as much as cyproterone acetate and has a permeation rate that is about 10 times greater than cyproterone acetate.
Also - apparently water can reduce absorption.
As is evident from the data in Table 12, water in the formulation can reduce cortexalone-17α-propionate's penetration into the skin.
(I think this vehicle here is obviously different from 1:1:1 transcutol, PG, eth.. but this is taken directly from the paper. I'm not an expert but I'll bet they're likely relatively interchangeable)
https://patents.google.com/patent/EP3108879A1
That is the patent. And this is what they were using as a vehicle... you can check out the patent it's right there. (At first I felt uneasy copying this but it's literally right there).
Based on the impurity profile, the formulation prepared in Example 4 is more stable than the aqueous formulation of Example 5.
The formulation described in Example 4 was studied in a clinical trial to evaluate its pharmacokinetic profile, safety, and tolerability.
Example 4: Anhydrous 5% w/w Solution- [0152]
A 5 weight percent (w/w) solution of cortexolone-17α-propionate having the components shown in Table 4, below, was prepared by solubilizing the therapeutic agent in the mixture of solvents followed by the addition of the antioxidant (ascorbyl palmitate) and the emulsifier (polysorbate 80). Table 4
Component Amount (g/100 g) Amount (Kg/ 15 Kg batch)
Cortexolone-17α-propionate 5.00 0.75
Diethylene glycol monoethyl ether 31.50 4.725
Alcohol (Ethanol) 31.50 4.725
Ascorbyl palmitate 0.50 0.075
Polysorbate 80 0.10 0.015
Propylene glycol 31.40 g 4.710
According to the study protocol, 1 ml of the formulation (corresponding to 50 mg of cortexolone-17α-propionate) was applied once a day on study day 1 and then twice daily thereafter on study days 2-28 to the areas of the scalp suffering from alopecia.
As can be seen from the data, cortexolone-17α-propionate permeates skin about 3 times as much as cyproterone acetate and has a permeation rate that is about 10 times greater than cyproterone acetate.
Also - apparently water can reduce absorption.
As is evident from the data in Table 12, water in the formulation can reduce cortexalone-17α-propionate's penetration into the skin.
(I think this vehicle here is obviously different from 1:1:1 transcutol, PG, eth.. but this is taken directly from the paper. I'm not an expert but I'll bet they're likely relatively interchangeable)
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we are 100 % sure they are releasing data this month ?
- Reaction score
- 115
They are releasing their financial report in February.. there’s a likelihood they’ll release the results shortly/during the release of their financials in order to excite investors lol.
The only promise they’ve made is that they’ll release data first half of 2019
The only promise they’ve made is that they’ll release data first half of 2019