- Reaction score
- 732
We all dream of a new revolutionizing active ingredient, a new drug that could treat our hair loss with no side effects. Especially sexual side effects. Well sometimes we have to look at a problem from another perspective to find new solutions.
We have very effective drugs like Finasteride and Dutasteride. However a portion of hair loss sufferers have debilitating side effects from these. So we have to find a better solution. The natural method to improve upon existing drugs is the delivery method, or vehicle.
I recently stumbled on a vehicle developed by the company iDelivery, for use in topical hair loss products. The stats were absolutely insane:
What is iDelivery’s vehicle?
-a diluted solution of a monoglyceride (stearic acid, unsaturated fats such as oleic and isostearic acid, or mixtures of these)
-dimyristoyl phosphatidylglycerol 1 mg/5 ml in chloroform/ethanol (ratio 1:9)
-90 mg/5 ml of Monomuls
-50 mg of Symperonic/5 ml
-Water (added dropwise under stirring)
Chloroform is evaporated and can be switched out with dichloromethane.
Thoughts?
We have very effective drugs like Finasteride and Dutasteride. However a portion of hair loss sufferers have debilitating side effects from these. So we have to find a better solution. The natural method to improve upon existing drugs is the delivery method, or vehicle.
I recently stumbled on a vehicle developed by the company iDelivery, for use in topical hair loss products. The stats were absolutely insane:
- 2.5 % iDelivery Minoxidil signficantly outcompeted 5 % Minoxidil in mice
- 74 (!) % of the drug was still in the follicle, compared to 18 % with another nanovehicle, and 1 % for the free drug.
- 86 % less side effects, due to the vehicle penetrating through the follicular openings and not skin. Thus only approx 10 % of the iDelivery goes systemic, compared to alcoholic vehicles. This is because follicular openings are only a maximum of 10 % of the scalp area.
- Theoretically one can use 50 % less drug, due to the amplification of compound delivery to the follicular site (up to two times theoretical increase)
What is iDelivery’s vehicle?
-a diluted solution of a monoglyceride (stearic acid, unsaturated fats such as oleic and isostearic acid, or mixtures of these)
-dimyristoyl phosphatidylglycerol 1 mg/5 ml in chloroform/ethanol (ratio 1:9)
-90 mg/5 ml of Monomuls
-50 mg of Symperonic/5 ml
-Water (added dropwise under stirring)
Chloroform is evaporated and can be switched out with dichloromethane.
Thoughts?