Discussion in 'Antiandrogens - Propecia, Dutasteride, etc.' started by Dimitri001, Jun 7, 2020.
2% or 1%? I really think that 1% is enough and with the minimum possibility of systemic absorption.
Similar camp here, most substances I apply topically go systemic for me - might as well be eating the damn things it makes very little difference.
First of all he didn't ask me for a study providing evidence that the mechanism for improving hair loss symptoms were due to being anti-inflammatory, just a study showing that it's anti-inflammatory. As you've rightly pointed out a complete picture of its MOA isn't really available, but my argument was that in the form of a shampoo with only a few minutes of contact, anti-androgenic effects are negligible when compared to the anti-inflammatory effects and seb. derm improvement.
Secondly, yes I'm aware that when taken orally in high doses it prevents testosterone production which I've already said. It doesn't however prevent testosterone from converting to DHT as its not an effective 5-ar inhibitor.
I've said nothing to contradict any of the literature out there, it's just that @jamesbooker1975 is a special breed of idiot with zero reading comprehension.
Nop, it can happen with the topical. Most probable will not happen with the shampoo. But you can simple test yours T levels. Contrary to other anti androgens that only affect the androgen receptor, this one block T synthesis . So you can easily find out.
You are not showing any study, just a review of dozen studies, none prove anti inflamatory effect.
Not a single one.
Every single one of those dozen studies shows it as well as the second link which is its own study. Learn to f*****g read I'm done with this. You're the only person on the planet that doesn't think ketoconazole is anti inflammatory.
Mental sides from nizoral shampoo? Ok...
Do you have a source on the claim that keto blocks t synthesis?
Lol, really ? pubmed ?
Do you have a link to a study?
Go to google and do the search, don't be lazy
I still use it, I use these shampoos:
Why not? That's a lot of enzymes inhibited...Granted the shampoo is unlikely to go systemic for vast majority of people, but maybe some have really porous scalps.
I used it for 6 months with Zix. I used the shampoo four times a week, twice everyday Nizoral 2% cream application on the hairline and twice a day Zix on the entire head.
It kept me above baseline (Yes, I even got minor regrowth from it) 6 months then I dropped Nizoral out of laziness and went back to baseline, which turned into below baseline after a while.