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How Come Nizoral/ketoconazole Isn't More Popular?

Discussion in 'Antiandrogens - Propecia, Dutasteride, etc.' started by Dimitri001, Jun 7, 2020.

  1. TomRiddle

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    2% or 1%? I really think that 1% is enough and with the minimum possibility of systemic absorption.
     
  2. whatevr

    whatevr Senior Member My Regimen

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    Similar camp here, most substances I apply topically go systemic for me - might as well be eating the damn things it makes very little difference.
     
  3. Throwaway94

    Throwaway94 Established Member My Regimen

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    First of all he didn't ask me for a study providing evidence that the mechanism for improving hair loss symptoms were due to being anti-inflammatory, just a study showing that it's anti-inflammatory. As you've rightly pointed out a complete picture of its MOA isn't really available, but my argument was that in the form of a shampoo with only a few minutes of contact, anti-androgenic effects are negligible when compared to the anti-inflammatory effects and seb. derm improvement.

    Secondly, yes I'm aware that when taken orally in high doses it prevents testosterone production which I've already said. It doesn't however prevent testosterone from converting to DHT as its not an effective 5-ar inhibitor.

    I've said nothing to contradict any of the literature out there, it's just that @jamesbooker1975 is a special breed of idiot with zero reading comprehension.
     
  4. jamesbooker1975

    jamesbooker1975 Senior Member My Regimen

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    Nop, it can happen with the topical. Most probable will not happen with the shampoo. But you can simple test yours T levels. Contrary to other anti androgens that only affect the androgen receptor, this one block T synthesis . So you can easily find out.
     
  5. jamesbooker1975

    jamesbooker1975 Senior Member My Regimen

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    You are not showing any study, just a review of dozen studies, none prove anti inflamatory effect.
    Not a single one.
     
  6. Throwaway94

    Throwaway94 Established Member My Regimen

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    Every single one of those dozen studies shows it as well as the second link which is its own study. Learn to f*****g read I'm done with this. You're the only person on the planet that doesn't think ketoconazole is anti inflammatory.
     
    TomRiddle likes this.
  7. inmyhead

    inmyhead Experienced Member

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    Mental sides from nizoral shampoo? Ok...
     
  8. Dimitri001

    Dimitri001 Established Member My Regimen

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    Do you have a source on the claim that keto blocks t synthesis?
     
  9. jamesbooker1975

    jamesbooker1975 Senior Member My Regimen

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    Lol, really ? pubmed ?
     
  10. Dimitri001

    Dimitri001 Established Member My Regimen

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    Do you have a link to a study?
     
  11. jamesbooker1975

    jamesbooker1975 Senior Member My Regimen

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    Go to google and do the search, don't be lazy
     
  12. jazz1

    jazz1 Established Member

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    I still use it, I use these shampoos:

    Nizoral
    Regenepure DR
    Lipogaine BIG3
    Revita
     
  13. whatevr

    whatevr Senior Member My Regimen

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  14. sonictemples

    sonictemples Experienced Member My Regimen

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    I used it for 6 months with Zix. I used the shampoo four times a week, twice everyday Nizoral 2% cream application on the hairline and twice a day Zix on the entire head.

    It kept me above baseline (Yes, I even got minor regrowth from it) 6 months then I dropped Nizoral out of laziness and went back to baseline, which turned into below baseline after a while.
     
    #54 sonictemples, Jul 11, 2020
    Last edited: Jul 11, 2020

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