How Come Nizoral/ketoconazole Isn't More Popular? | HairLossTalk Forums

How Come Nizoral/ketoconazole Isn't More Popular?

Discussion in 'Antiandrogens - Propecia, Dutasteride, etc.' started by Dimitri001, Jun 7, 2020.

  1. Dimitri001

    Dimitri001 Established Member My Regimen

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    A lot of people are reluctant to get on antiandrogens for fear of sides and, from what I've seen, ketoconazole applied topically doesn't have systemic effects, so how come keto isn't a popular alternative to finasteride and so forth? I very rarely see it mentioned on the forum?
     
  2. Lucky_Luciano

    Lucky_Luciano Established Member My Regimen

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    Because its too weak for an antiandrogen but still does in many more harm then good. It dries out your hair and may thin it out. Some use it in addition to their regimens as an anti-inflammary.
     
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  3. Derelict

    Derelict Senior Member My Regimen

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    I have read people have had some success with using topical keto cream on their scalps but i don't know much about it, maybe if your hair loss was very minor it could help but im not so sure tbh. Oral keto is out of the question, im not evens sure if it would work but it's a hardcore drug. Try a combination of cream and shampoo if you want to stick to keto only and see if you get any results, but like i said, i think it would only work if your hair loss was minor.
     
    #3 Derelict, Jun 7, 2020
    Last edited: Jun 7, 2020
  4. jazz1

    jazz1 Experienced Member

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    I use these shampoos:

    Nizoral
    Regenepure DR
    Lipogaine BIG3
    Revita
     
  5. Mr White

    Mr White Established Member

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    It seems that Revita in Europe doesn't contain keto, you'll have to order from the US. I recently ordered Regenepure shampoos on Amazon, I can't wait to try it.
     
  6. Mr White

    Mr White Established Member

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    I use Nizoral 1x week but it dries out your scalp. I've ordered Regenepure from Amazon, reviews are great and I can't wait to try it.
     
  7. SteveTabernack

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    Because it's straight trash.
     
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  8. pegasus2

    pegasus2 Senior Member My Regimen

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    It's worth using since it takes no effort, just use it as your normal shampoo 3 times a week. When taken orally it's a very potent anti-androgen, but it can't be used orally due to a poor safety profile. Topically it is safe, and its benefits go well beyond just being an anti-androgen.

    The ketoconazole group showed an 18% increase in hair density compared to an 11% increase in hair density for the minoxidil group. The ketoconazole group also demonstrated a 19.4% decrease in the mean sebaceous gland area, which, in contrast, was increased by 5.3% in the minoxidil plus unmedicated shampoo group. Scalp sebaceous glands affected by hair loss bind androgens with greater affinity and capacity than their hairy counterparts.
    https://onlinelibrary.wiley.com/doi/full/10.1111/dth.13202#
     
    #8 pegasus2, Jun 12, 2020
    Last edited: Jun 13, 2020
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  9. jazz1

    jazz1 Experienced Member

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    That’s correct, I managed to buy 925ml bottles from a genuine eBay seller who ships from abroad. Revita is great, but shame they removed the Keto, on the positive note I still use Nizoral so you can always add that to Revita.
     
  10. Dimitri001

    Dimitri001 Established Member My Regimen

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    Those of you who've bought from the US into Europe, how much did shipping run you and, if you don't mind saying, what country are you from?
     
  11. Derelict

    Derelict Senior Member My Regimen

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    Where are you from? here in the uk keto 2% is otc.
     
  12. resu

    resu Senior Member

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    If you're having an itch from sebo or dandruff might be useful.
     
  13. Capone

    Capone Senior Member

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    It’s ok maybe once a week as it fries my hair and thins it out.
     
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  14. Throwaway94

    Throwaway94 Experienced Member My Regimen

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    It's extremely popular what are you talking about? As an antiandrogen it's pretty much ineffective though. It's good for seb. dermatitis from which many people balding or on minoxidil tend to suffer.
     
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  15. Dimitri001

    Dimitri001 Established Member My Regimen

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    I'm from Croatia.

    Here, there's only one brand of keto shampoo available (I emailed a dozen pharmacies) and it contains a cancerogenic substance.
     
  16. jamesbooker1975

    jamesbooker1975 Senior Member My Regimen

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    Hahahahahahahahah. Yes, sure, cause you say so. It is one of the few drugs, that have more than 10 studies done in humans with Androgenetic alopecia, and in every one was a success.
    Learn to use it, well, first learn to read.
     
  17. jamesbooker1975

    jamesbooker1975 Senior Member My Regimen

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    Yes, pretty much ineffectice cause you say so. Can you please explain it how it is so good on acne ? please don't tell me cause it is good for seb. Or may be you can explain us how it is good on seb ? may be cause it antiandrogenic effects ?!?!!?!?!?!!
     
  18. jamesbooker1975

    jamesbooker1975 Senior Member My Regimen

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    Because more people are idiot and they only buy what they sell you on propaganda. If you are smart enought, read studies on pubmed , Ketoconazole, minoxidil, tretinoin , are the best combo without side effects.
    also, there are people that use it two time per week, a couple of weeks, leaving a couple of minutes and say it is crap, lol .
     
  19. tomJ

    tomJ Senior Member My Regimen

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    Nizoral definitely goes systemic in thin scalp people. I am one of them. I get fatigue and moody and mentally cloudy soon after using it. The effects last anywhere from 3 to 48 hours for me. Even messes with my heart. My experiences are however probably very rare.
     
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  20. whatevr

    whatevr Senior Member My Regimen

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    Because it is garbage that dries out your hair with absolutely no semblance of real world results. It works only in the vacuum of Pubmed studies just like many other things. LLLT, Saw Palmetto, and various other herbs probably have more evidence to back up their efficacy than ketoconazole yet we know those don't work. How it deserves a place in the "Big 3" is beyond me.

    Here is a study showing your precious ketoconazole (with all its mighty antiandrogen properties) outperformed by simple piroctone olamine which gives more increase in hair count and diameter without even having any kind of AA effect or known side effect profile.

    https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1467-2494.2002.00145.x

    Laughable.
     
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