No offense, but you sound like a hypochondriac and a pessimist. The only concern I have is if the drug works in humans. We could have some redundant pathway the monkeys don't have which will keep HFSCs quiescent even without PRLRs. This seems unlikely, but much more likely than PRLR antagonism being life threatening. Male mice without prolactin receptors live normal lives.
Not really, we already know several pathways that hairloss can be stopped but we can’t inhibit or enhance those pathways due to obvious side effects on the whole body. That’s the challenge with fighting hairloss. E.g the wnt pathway, the TGF-β1 suppressed by Botox and DHT through finasteride.
Prolactin isn’t a hormone like DHT, it’s involved in immune system and other important biological functions. Unlike DHT which is mainly sexual and it’s involved in causing diseases after a certain age (prostate)
So yeah, I am cautious and not really getting my hopes up until they can prove it’s safety in large trials