HDAC 4 Is most likely the cause of our suffering

[pegasus2]

okay I will. But could you explain why that study I am referring to says it’s downregulated?

I don't know. Like Twist1, Twist2 also has opposing effects depending on dimer composition. It could be that the balance of Twist2 dimer composition is altered in Androgenetic Alopecia, and that increases its ability to recruit HDAC2 even though there is less Twist2.

Since we know how Twist2's negative effects are mediated it would be better to just inhibit HDAC2 and maybe promote reacetylation with p300.

 

[Mr. Slap Head]

Your regimen is Castor oil and peppermint oil thats it.

Makes you poop

 

[EndlessPossibilities]

I don't know. Like Twist1, Twist2 also has opposing effects depending on dimer composition. It could be that the balance of Twist2 dimer composition is altered in Androgenetic Alopecia, and that increases its ability to recruit HDAC2 even though there is less Twist2.

That makes sense. The complexity of this all is absolutely ridiculous but if ur theory on pkc and prolactin causing a rise in twist1 is correct that would explain the prolactin antibody success and could truly mean that is a promising treatment provided Sid effects aren’t bad

 

[Mr. Slap Head]

Finasteride and minoxidil. What else is new lol

 

[losingbattle88]

That makes sense. The complexity of this all is absolutely ridiculous but if ur theory on pkc and prolactin causing a rise in twist1 is correct that would explain the prolactin antibody success and could truly mean that is a promising treatment provided Sid effects aren’t bad

U Still use folic acid methylene blue mk677 and b12? Mk677 is said to benefit hair damn..

 

[EndlessPossibilities]

Makes you poop

All around bad sh*t. Dont waste ur time.

U Still use folic acid methylene blue mk677 and b12? Mk677 is said to benefit hair damn..

mk677. Cause Gyno. Methylene blue didnt do sh*t. And folic acid and b12 only matter if u are deficient. If all the things out there that’s natural based. I was say only 5 percent can actually help us. In other words everything is snake oil. If there are no human studies throw it away. With he except of. Carnitine. May be actually useful.

 

[Hairful]

What is funny is there are people who are yearning for and willing to try dangerous compounds to inhibit gene expression/hormones that have serious implications and science doesn’t know much about. That affect the skeletal system and a myriad of other functions.

From the fear of taking finasteride which blocks some DHT which has been shown to be mostly bad after puberty. But our knowledge of it is much more and finasteride has decades of safety data available.

Ficking hell, absolutely blows my mind. Irrational people imagine symptoms from finasterde for years after stopping it when it doesn’t even block the enzyme completely, imagine actually turning off genes that you are clueless about.

Shitty pseudo bro science. At least it’s entertaining to read I guess to read absurd theories

 

[EndlessPossibilities]

What is funny is there are people who are yearning for and willing to try dangerous compounds to inhibit gene expression/hormones that have serious implications and science doesn’t know much about. That affect the skeletal system and a myriad of other functions.

From the fear of taking finasteride which blocks some DHT which has been shown to be mostly bad after puberty. But our knowledge of it is much more and finasteride has decades of safety data available.

Ficking hell, absolutely blows my mind. Irrational people imagine symptoms from finasterde for years after stopping it when it doesn’t even block the enzyme completely, imagine actually turning off genes that you are clueless about.

Shitty pseudo bro science. At least it’s entertaining to read I guess to read absurd theories

It’s not bro science. It’s actual science. People are taking risking ya. In the hopes of a lower side effect profile And I know Pegasus has been making huge gains. Granted I wouldn’t try unknown research drugs on myself.

 

[Mr. Slap Head]

What is funny is there are people who are yearning for and willing to try dangerous compounds to inhibit gene expression/hormones that have serious implications and science doesn’t know much about. That affect the skeletal system and a myriad of other functions.

From the fear of taking finasteride which blocks some DHT which has been shown to be mostly bad after puberty. But our knowledge of it is much more and finasteride has decades of safety data available.

Ficking hell, absolutely blows my mind. Irrational people imagine symptoms from finasterde for years after stopping it when it doesn’t even block the enzyme completely, imagine actually turning off genes that you are clueless about.

Shitty pseudo bro science. At least it’s entertaining to read I guess to read absurd theories

It’s spergscience brah

 

[pegasus2]

What is funny is there are people who are yearning for and willing to try dangerous compounds to inhibit gene expression/hormones that have serious implications and science doesn’t know much about. That affect the skeletal system and a myriad of other functions.

From the fear of taking finasteride which blocks some DHT which has been shown to be mostly bad after puberty. But our knowledge of it is much more and finasteride has decades of safety data available.

Ficking hell, absolutely blows my mind. Irrational people imagine symptoms from finasterde for years after stopping it when it doesn’t even block the enzyme completely, imagine actually turning off genes that you are clueless about.

Shitty pseudo bro science. At least it’s entertaining to read I guess to read absurd theories

The people who are afraid to take finasteride are taking vitamins. The ones using research chemicals are the ones finasteride doesnt work on. Finasteride is a maintenance drug. We need drugs that can reverse norwoods.

 

[EndlessPossibilities]

The people who are afraid to take finasteride are taking vitamins. The ones using research chemicals are the ones finasteride doesnt work on. Finasteride is a maintenance drug. We need drugs that can reverse norwoods.

Finasteride never worked for me. Only negative permanent side effects. f*** that drug.

 

[pegasus2]

Finasteride never worked for me. Only negative permanent side effects. f*** that drug.

It doesn't give me side effects, but I waited too long to take it. It isn't enough for regrowth.

 

[Hairful]

It’s not bro science. It’s actual science. People are taking risking ya. In the hopes of a lower side effect profile And I know Pegasus has been making huge gains. Granted I wouldn’t try unknown research drugs on myself.

Try harmine and report back findings

 

[pegasus2]

Try harmine and report back findings

Hair growth is already reported from the plant it comes from

 

[Hairful]

Hair growth is already reported from the plant it comes from

Side effects at doses sufficient to reverse hairloss better than minxodil and finasteride?

 

[pegasus2]

Side effects at doses sufficient to reverse hairloss better than minxodil and finasteride?

Syrian Rue is a folk remedy for hair loss, but if it was potent enough to compete with minoxidil then it would probably be more widely known. I have not seen reports of anyone trying refined harmine on their scalp.

 

[pegasus2]

Saethra chotzen disease. Low and or dysfunctioning twist1. Results in zero recession in all including adult males at least based on all the online presentations.


we just need to figure out a few things. how do the hdacs regulate these twists and how can we regulate them ourselves. And we need to figure out what do with twist2.

Intersting that the majority of cases are due to single gene mutations in FGFR2/3 or Twist1.

The genes most frequently mutated were FGFR2 (32% of all genetic cases), FGFR3 (25%), TWIST1 (19%) and EFNB1 (7%)

Craniosynostosis - European Journal of Human Genetics

Craniosynostosis, defined as the premature fusion of the cranial sutures, presents many challenges in classification and treatment. At least 20% of cases are caused by specific single gene mutations or chromosome abnormalities. This article maps out approaches to clinical assessment of a child...

www.nature.com

A couple more adult males with the syndrome

 

[Feelsbadman.jpg]

https://www.amazon.com/Harmine-Harmaline-HCL-1-GR/dp/B08PQBC1H6

Looks to be easily procured and cheap.

 

[EndlessPossibilities]

@pegasus2 did u notice the twist 2 syndromes one of them results in hella body hair. Which would finally explain the increased body hair on men and head loss as they age. Like wow. We legit discovered the f*****g problem and no research is being done?

 

[RagnarLothbrok]

galea theory bros are on celebration