Quadzilla99
Established Member
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I agree that the sustain version is probably the best due to NAC's extensive first pass metabolism...but just standard NAC also works well if dosed properly
Curr Opin Pharmacol. 2007 Aug;7(4):355-9. Epub 2007 Jun 29.
N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency.
Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA.
Source
Department of Genetics, School of Medicine, Stanford University, B007 Beckman Center, 279 Campus Drive, Stanford University, CA 94305-5318, United States. atkuri@stanford.edu
Abstract
Glutathione (GSH) deficiency is associated with numerous pathological conditions. Administration of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. NAC, best known for its ability to counter acetaminophen toxicity, is a safe, well-tolerated antidote for cysteine/GSH deficiency. NAC has been used successfully to treat GSH deficiency in a wide range of infections, genetic defects and metabolic disorders, including HIV infection and COPD. Over two-thirds of 46 placebo-controlled clinical trials with orally administered NAC have indicated beneficial effects of NAC measured either as trial endpoints or as general measures of improvement in quality of life and well-being of the patients.
It seems to work best in people with a glutathione deficiency caused by some adverse condition though. In healthy people it stops working after a while and has the opposite effect. Thats why some people (myself included) dose it irregularly like take a bunch one day a week or one week/one week off. At least thats my understanding.
Curr Opin Pharmacol. 2007 Aug;7(4):355-9. Epub 2007 Jun 29.
N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency.
Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA.
Source
Department of Genetics, School of Medicine, Stanford University, B007 Beckman Center, 279 Campus Drive, Stanford University, CA 94305-5318, United States. atkuri@stanford.edu
Abstract
Glutathione (GSH) deficiency is associated with numerous pathological conditions. Administration of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. NAC, best known for its ability to counter acetaminophen toxicity, is a safe, well-tolerated antidote for cysteine/GSH deficiency. NAC has been used successfully to treat GSH deficiency in a wide range of infections, genetic defects and metabolic disorders, including HIV infection and COPD. Over two-thirds of 46 placebo-controlled clinical trials with orally administered NAC have indicated beneficial effects of NAC measured either as trial endpoints or as general measures of improvement in quality of life and well-being of the patients.
It seems to work best in people with a glutathione deficiency caused by some adverse condition though. In healthy people it stops working after a while and has the opposite effect. Thats why some people (myself included) dose it irregularly like take a bunch one day a week or one week/one week off. At least thats my understanding.
