Follica Microneedling Protocol Patent Disclosed

glammetal

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AFAIK there haven't been any studies about this however if it truly generates new hair follicles it should. It's possible fibrosis could reduce the effects but even then microneedling reduces fibrosis...
Damn that follica finished phase 2 in December 2019.They take this thing too damn slow
 

Chromeo

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Lol, that's saying nothing whether it will take a few months after stopping, or if it will take 20-30 years like his original hair.
It's pretty clear from his documentation that they are lost quickly. He's been off his regime for 4 months and he appears to have lost a considerable amount of ground already.
 

BalderBaldyBald

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For the record, Dr. Cotsarelis mentioned at a Follica conf years ago that its not a silver bullet treatment, Finasteride will still be required to maintain and avoid DHT damage

Another curious fact, let's say you've been 20 years on Finasteride and have been capable of maintaining a NW2-3 pattern, avoiding a complete horseshoe NW7 pattern this long time.
If you stop Finasteride, you'll be back at your "pre-programmed" final pattern (NW7 for heavy balders) in a matter of months, the kickback is hard and fast
 

JaneyElizabeth

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Good point. We might be able to maintain microneedling using duta/finasteride or other prostate medications. What might happen also is that many/most derma-rollers are operating in an environment of higher levels of DHT as a baseline and so then, when one stops, it's like whoosh in comes the DHT and I think I have seen people noting complete fall-out after desisting from microneedling for 30 to 180 days.
He stopped all of his regime (finasteride, minoxidil, dermarolling) so of course all gains will be lost. For a start, any hairs regrown on the top of the head by dermarolling are still susceptible to the negative effects of DHT, so without finasteride they will miniaturise the same way they did before. They are not DHT-resistant hairs like those from the donor area.
 

pegasus2

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I think Twist1 is constitutively active in bald scalp and this acts as a brake on Wnt signaling and the growth phase of the hair follicle. Microneedling increases Wnt ligands while minoxidil inhibits GSK3b(Wnt inhibitor) and this counteracts Twist1's suppression of Wnt signaling, but Twist1 is still there, and when you remove microneedling and minoxidil the balding process happens again swiftly due to the constitutively nuclear Twist1 combined with your cells already having reached an age where they are more easily stressed. It's similar to how when older eunuchs are given testosterone their hair falls out more quickly than younger eunuchs, only this is much worse because you already have high Twist1 expression. I believe PRLR antagonism reverses the cause of constitutive Twist1, and that's why results from HMI-115 last much longer after discontinuing treatment than the results from minoxidil and microneedling.
 

JaneyElizabeth

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Good point. We might be able to maintain microneedling using duta/finasteride or other prostate medications. What might happen also is that many/most derma-rollers are operating in an environment of higher levels of DHT as a baseline and so then, when one stops, it's like whoosh in comes the DHT and I think I have seen people noting complete fall-out after desisting from microneedling for 30 to 180 days.
But much longer anagen might trump the importance of DHT somewhat and a lot of the analysis ends up being circular in terms of cause and effect and which is which.
 

JaneyElizabeth

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Also, microneedling can heal really bad scarring very, very well. It seems to have youth and healing effects on all tissue and I am willing to bet that shrink donor area scarring and also cobblestone or baby doll hairline scarring. Grafts that had given up the ghost now appear to all lie flush and are productive of excellent hair not the eh hair from transplants for diffuse thinners like me. I do it weekly on ever single cm of my body above the ahem, tits. Yes, I tried rolling them too but the pain was too great to do it much there.
 

EMILIO CHESSA

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I think Twist1 is constitutively active in bald scalp and this acts as a brake on Wnt signaling and the growth phase of the hair follicle. Microneedling increases Wnt ligands while minoxidil inhibits GSK3b(Wnt inhibitor) and this counteracts Twist1's suppression of Wnt signaling, but Twist1 is still there, and when you remove microneedling and minoxidil the balding process happens again swiftly due to the constitutively nuclear Twist1 combined with your cells already having reached an age where they are more easily stressed. It's similar to how when older eunuchs are given testosterone their hair falls out more quickly than younger eunuchs, only this is much worse because you already have high Twist1 expression. I believe PRLR antagonism reverses the cause of constitutive Twist1, and that's why results from HMI-115 last much longer after discontinuing treatment than the results from minoxidil and microneedling.
Hello ... I wrote to you in private ... I hope not to disturb thanks
 

kiwi666

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Do you know only microneedling users (without other treatment)? With pictures or testimony?
If we use minoxidil, after an amount of time, it will be less and less effective. But will the hair gained through microneedling last over time or not?
No we do not.
 

BalderBaldyBald

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If we stop microneeedling, it goes back, like when we stop minoxidil or gains are maintained ?

Sweet innocence, believing a roller gonna save his fullhead
No it won't, there's nothing stronger than DHT dmg, and it's get worse as you age, your androgen sensivity will increase thus your hairloss with it
A roller by itself won't be enough (if you really have Androgenetic Alopecia and not a mature hairline with a huge BDD problem of course)

There's a few who magically self stabilize before reaching NW7, don't know why exactly, like if final Norwood pattern was written in your gene pool somewhere, but don't hope solely on that

Big 3 (and Dermaroll for a sweet enhance effect, minoxidil absorption, fibroblasts stimulation) is still all we got, and for some, even those synergic treatments are not enough to maintain despite a continuous usage, so what do you expect as a answer ? All those treatments are for LIFE son, welcome to hell

NO as a definitive answer, proof is life, people out there who still balding, and history of mankind, and most likely the fact that we hear about dermaroller for like 20 years now, if only this was so easy
 
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Roeysdomi

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Sweet innocence, believing a roller gonna save his fullhead
No it won't, there's nothing stronger than DHT dmg, and it's get worse as you age, your androgen sensivity will increase thus your hairloss with it
A roller by itself won't be enough (if you really have Androgenetic Alopecia and not a mature hairline with a huge BDD problem of course)

There's a few who magically self stabilize before reaching NW7, don't know why exactly, like if final Norwood pattern was written in your gene pool somewhere, but don't hope solely on that

Big 3 (and Dermaroll for a sweet enhance effect, minoxidil absorption, fibroblasts stimulation) is still all we got, and for some, even those synergic treatments are not enough to maintain despite a continuous usage, so what do you expect as a answer ? All those treatments are for LIFE son, welcome to hell

NO as a definitive answer, proof is life, people out there who still balding, and history of mankind, and most likely the fact that we hear about dermaroller for like 20 years now, if only this was so easy
Facts can we stop act like derma is a treatment ? Its just for improvment of minoxidil results in the first 1-2 years after that you wont get any improvment ...
 

cryingariver

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Facts can we stop act like derma is a treatment ? Its just for improvment of minoxidil results in the first 1-2 years after that you wont get any improvment ...
aren't you on the wrong thread then? this thread is about MICRONEEDLING.
 

cryingariver

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Really? So this thread was started six months ago about company doing and planning nothing?
not necessarily. Follica released their Microneedling protocol. that's what this thread is about. if you're looking for a hair loss cure... well.... another 15 years?
 

Terem

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I'm surprised to see so much informations around microneedling I searched for weeks before finding this community and this thread in particular so I thank everyone for their contributions... I have a question tho, in the first post the guy says to move the device in horizontal and vertical direction but when i bought the pen I thought moving it while keeping it on the skin could cause unwanted damage to the tissue (like a bruise and a post here seems to show exactly that) so what I've been doing these weeks is tapping the pen on the head instead of moving it, is it wrong? Should I get a derminator or can I do it like this? I don't think I can send it back even if I bought it on amazon and use just one head.
 
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