Exploring The Hormonal Route. Hair=life.

[Pey'J]

Strange, I have a slight allergy in the form of itchy eyes and a sweaty nose. I don’t even know what component of RU can cause such a reaction. The allergy is not severe, so I will tolerate it. Maybe it will go away on its own.

yea dont worry too much, goes away after a couple months

 

[Pey'J]

My DHT was also quite high at zero T. Any ways to block the backdoor of DHT synthesis?

block the receptor, not much else you can do if you are a DHT mutant

 

[MylovelyHair]

For me, things are a little more serious. I sleep for 12 hours and still have difficulty getting out of bed, and after 5 hours I feel unbearably sleepy again. I feel extremely weak and cannot work. I hope this ends soon.
The worst thing is that if RU helps me and I decide to restore my own testosterone production, it will take many months; probably a whole year. I don’t know how you can live in this state for a whole year, it kills life. Hopefully my testicular T production will return quickly, but given how long I've been on HRT, it would take a miracle for that to happen.

one thing that helped me was vitamin D3 i was very low but still quality of life is very low !! Me too i need a lot of sleep i have muscle weakness i get tired easily can't get hard 100% and i don;t have motivation to workout.I wonder if i could maintain my hair on oral minoxidil 22 mg hair is not an issue any more but i need to find something with less impact on quality of life!Also dutasteride make me hold more fat on stomach area (not weight gain)!

 

[Almas_NW0]

Great news: I felt better within 5 days of the injection. I feel fine, the testosterone has worked. It is usually said that the first effect of T is oily skin: it appears immediately as soon as T increases. But since I take Bicalutamide, my skin is as dry as it was on HRT.

 

[MylovelyHair]

Great news: I felt better within 5 days of the injection. I feel fine, the testosterone has worked. It is usually said that the first effect of T is oily skin: it appears immediately as soon as T increases. But since I take Bicalutamide, my skin is as dry as it was on HRT.

Excellent !! Have you ever thought to try take oral minoxidil and dutasteride plus RU you could maintain your hair and stop bicalutamide??Do you have sensitive and painful nips??

 

[GRme11]

My DHT was also quite high at zero T. Any ways to block the backdoor of DHT synthesis?

In a bit of a just pure theory of going all in:
Dutasteride+Bicalutamide and perhaps Abiraterone Acetate (?).

Although, Duta+Bica is very potent. Well, a 5AR inhibitor+a non steroidal anti androgen (Bica, RU, Pyri, etc.).

But Dutasteride alone supposedly tackles the Backdoor through the 5AR1. That’s why it’s a more complete 5AR inhibitor than Finasteride. (Check figure)

https://upload.wikimedia.org/wikipedia/commons/0/0a/Androgen_backdoor_pathway.svg

https://www.reddit.com/r/DrWillPowers/comments/1bhvbja

Androgen backdoor pathway - Wikipedia

en.m.wikipedia.org

Look the nasty AKR1C2, 17B-HSD6, DHR9S, RDH16, RDH5

Read biochemistry in the Wikipedia link.

Also, a reminder: There are two known physiologically and clinically significant 11-oxygenated androgens, 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone(11KDHT), which both bind and activate the androgen receptor with affinities, potencies, and efficacies that are similar to that of testosterone (T) and DHT, respectively.[4][3]

Plus, 3a-diol-G is an important marker:http://immunotech.cz/Media/Default/Page/A-G_analyte_info.pdf

I wrote it as well to my thread:https://www.hairlosstalk.com/intera...ation-of-hair-follicles-and-3a-diol-g.134542/

 

[losingbattle88]

Idk. Im already taking dutas and bica so I don't think so. Bica gets me covered as long as it doesn't get crazy high DHT which I doubt. Anyways I have 0.07 ng/ml 3a diol G so in theory I have very low circulating androgens, but ofc this is always the theory, which can differ from reality.

one thing that helped me was vitamin D3 i was very low but still quality of life is very low !! Me too i need a lot of sleep i have muscle weakness i get tired easily can't get hard 100% and i don;t have motivation to workout.I wonder if i could maintain my hair on oral minoxidil 22 mg hair is not an issue any more but i need to find something with less impact on quality of life!Also dutasteride make me hold more fat on stomach area (not weight gain)!

Bro yes try to maintain on oral minoxidil. Those sides sounds horrible.

 

[losingbattle88]

For me, things are a little more serious. I sleep for 12 hours and still have difficulty getting out of bed, and after 5 hours I feel unbearably sleepy again. I feel extremely weak and cannot work. I hope this ends soon.
The worst thing is that if RU helps me and I decide to restore my own testosterone production, it will take many months; probably a whole year. I don’t know how you can live in this state for a whole year, it kills life. Hopefully my testicular T production will return quickly, but given how long I've been on HRT, it would take a miracle for that to happen.

Well fuk it. Im back on oral minoxidil and RU daily.

 

[losingbattle88]

You guys really need to move on from these shitty ineffective treatments from the 80s and get on the pink pill asap, it clearly isn't working since you're both nw7.

Easy for you to say, you were never a man to begin with. Its an easy choice for you.

 

[Ryuzaki hedeki]

Hrt users when do e2 effects start to kick in to my hair and facial cheekbones ? Because I can't wait to get into modeling

 

[Adri23]

Hrt users when do e2 effects start to kick in to my hair and facial cheekbones ? Because I can't wait to get into modeling

I started to see effects on face at 3 months but it maximized at around 1 y and 6 months. Hair took a while like 1 year on HRT but I think it was because the first 6 months I was using sublingual e2 + CPA which made my hair worse. I think you can recover hair within 6 months if you use injections + bica.

 

[exwhyyou]

 

[Adri23]

View attachment 187168

No problem!

 

[Pey'J]

No problem!

how bad is ur gyno

 

[Adri23]

how bad is ur gyno

Considering all the stuff I take, not bad at all. I gotta be honest here my BMI is 17.2 so I am skinny as hell. I have legit 0 fat on my body

 

[losingbattle88]

Considering all the stuff I take, not bad at all. I gotta be honest here my BMI is 17.2 so I am skinny as hell. I have legit 0 fat on my body

Thats because ur young with fast metabolism. I got a belly at 36 and if I took estrogen I would blow up like a toad. Estrogen does not reduce fat percentage in males it does the opposite.

 

[MylovelyHair]

Thats because ur young with fast metabolism. I got a belly at 36 and if I took estrogen I would blow up like a toad. Estrogen does not reduce fat percentage in males it does the opposite.

Any man that uses estrogen for hair needs help there is a thing called common sense and logic

 

[losingbattle88]

Any man that uses estrogen for hair needs help there is a thing called common sense and logic

Ye but they werent real men to begin with.

 

[AnotherBloke]

Wow , someone get me some popcorn

 

[exwhyyou]

Sure he is Pile.What do you think you are?

Happy Easter tego! He is risen <3