Exploring The Hormonal Route. Hair=life.

GRme11

GRme11

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Xader said:
You guys don't understand one thing. Only DHT matters in androgenic alopecia. You can even remove your testicles, but if your body still produces sufficent amount of DHT (via backdoor pathway) then you are still going to be bald. DHT is a hormone that is not only produced by 5 alpha reductase... That’s why a lot of people who take finasteride/dutasteride are still going bald and often they have a DHT levels in normal male range...

You can have a testosterone levels 0 but your DHT can still be high in some cases and you can do nothing about that.
Click to expand...
Well, Dutasteride it is supposed to attack the Backdoor pathway of dht via the 5AR1 enzyme, but for others will be enough and probably for others not. DHT being high to those who take it’s pretty crazy. There are genetic variations, etc. Nothing is fully understood yet/completely. No to mention the scalp DHT/androgens. There is even a study where Dutasteride+3a oxidoreductase inhibitors inhibited DHT more completely than Dutasteride alone in advance prostate cancer which makes sense because the Backdoor pathway is inhibited more “completely”. From the Backdoor chart, someone can conclude that the following could inhibit it in a more “complete” way:

Dutasteride
Ketoconazole
Abiraterone
Aldo-Ketoreductases
etc

The following studies are pretty good. Worth a look.


Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer - PMC

Prostate cancer (PCa) growth and progression rely on the interaction between the androgen receptor (AR) and the testicular ligands, testosterone and dihydrotestosterone (DHT). Almost all men with advanced PCa receive androgen deprivation therapy ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia - PMC

Dutasteride, a dual inhibitor of both type I and II 5α-reductases, is used to treat male pattern hair loss (MPHL). However, patient response to dutasteride varies in each individual, the cause of which is yet to be identified. To identify genetic ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
 

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GRme11

GRme11

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GRme11 said:
Well, Dutasteride it is supposed to attack the Backdoor pathway of dht via the 5AR1 enzyme, but for others will be enough and probably for others not. DHT being high to those who take it’s pretty crazy. There are genetic variations, etc. Nothing is fully understood yet/completely. No to mention the scalp DHT/androgens. There is even a study where Dutasteride+3a oxidoreductase inhibitors inhibited DHT more completely than Dutasteride alone in advance prostate cancer which makes sense because the Backdoor pathway is inhibited more “completely”. From the Backdoor chart, someone can conclud that the following could inhibit it in a more “complete” way:

Dutasteride
Ketoconazole
Abiraterone
Aldo-Ketoreductases
etc

The following studies are pretty good. Worth a look.


Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer - PMC

Prostate cancer (PCa) growth and progression rely on the interaction between the androgen receptor (AR) and the testicular ligands, testosterone and dihydrotestosterone (DHT). Almost all men with advanced PCa receive androgen deprivation therapy ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia - PMC

Dutasteride, a dual inhibitor of both type I and II 5α-reductases, is used to treat male pattern hair loss (MPHL). However, patient response to dutasteride varies in each individual, the cause of which is yet to be identified. To identify genetic ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
Click to expand...
Also, you can take a look in my thread here. I think I have gathered good information.

 
Mr. Slap Head

Mr. Slap Head

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Even KCMB never had hair loss, yet comes on here to give advice to people with actual hair loss lmao it’s pathetic. Clearly just on here for validation, same as the other incels. Janey actually had hair loss, was more intelligent, and contributed more beneficial content.
 
yung recession

yung recession

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why are yall in this thread if you aren’t on hrt or interested in it. there’s balding but then there’s being so mentally damaged by balding you harass people on a hair loss forum
 
losingbattle88

losingbattle88

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yung recession said:
nah dutasteride didnt stop my hair loss. growing tits is whatever ill have em operated off. once ive secured that my hair loss is halted then ill get a transplant if i don’t get a lot of regrowth
Click to expand...
Have u told your girlfriend that ur gonna be a tranny? Lol. Bro hair isnt worth to demasculine yourself man. I would never do it. Too many bad sides and no semen. Ur being desperate.
 
yung recession

yung recession

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losingbattle88 said:
Have u told your girlfriend that ur gonna be a tranny? Lol. Bro hair isnt worth to demasculine yourself man. I would never do it. Too many bad sides and no semen. Ur being desperate.
Click to expand...
yea I have. once i or if i grow my hair back I’ll stop it and go on Clomid therapy to restore my T. I think this is what almasnw0 did
 
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