Well, Dutasteride it is supposed to attack the Backdoor pathway of dht via the 5AR1 enzyme, but for others will be enough and probably for others not. DHT being high to those who take it’s pretty crazy. There are genetic variations, etc. Nothing is fully understood yet/completely. No to mention the scalp DHT/androgens. There is even a study where Dutasteride+3a oxidoreductase inhibitors inhibited DHT more completely than Dutasteride alone in advance prostate cancer which makes sense because the Backdoor pathway is inhibited more “completely”. From the Backdoor chart, someone can conclud that the following could inhibit it in a more “complete” way:
Dutasteride
Ketoconazole
Abiraterone
Aldo-Ketoreductases
etc
The following studies are pretty good. Worth a look.
Prostate cancer (PCa) growth and progression rely on the interaction between the androgen receptor (AR) and the testicular ligands, testosterone and dihydrotestosterone (DHT). Almost all men with advanced PCa receive androgen deprivation therapy (ADT). ...
www.ncbi.nlm.nih.gov
Dutasteride, a dual inhibitor of both type I and II 5α-reductases, is used to treat male pattern hair loss (MPHL). However, patient response to dutasteride varies in each individual, the cause of which is yet to be identified. To identify genetic ...
www.ncbi.nlm.nih.gov