Before this I was taking stable Cyprus12.5mg Finasteride 2.5mg and Minoxidil 8mg I was so I was looking for regrowth and I changed therapy ... my therapy for a month is now composed of: dutasteride 0.5mg- bicalutamide100mg-minoxidil oral and lotion with 12 mg-dutasteride 0.5 g and estradiol Topic 0.001 g. These are my blood tests .. and I wonder how it is possible to have a dht so high despite the topical and oral dutasteride in my regime?
I ask for advice because unfortunately my situation is getting worse despite the treatment I am using ... I hope you can help me thanks.
26/04/2022
Exam description Result Reference values
ALBUMINEMIA ........................ 4.60 3.2-4.8 g / dl U
Method: CHEMICAL
TESTOSTERONE ....................... 7.97 Male: 1.75 - 7.81 ng / ml M
Method: ELECTRO-CHEMILUMINESCENCE RESULT CONFIRMED AFTER REPEAT Female: <0.1 - 0.75 ng / ml
FREE TESTOSTERONE .................. 11.49 Man <12 years 0-4.6 pg / ml U
Method: ELISA Male> 12 years 0.18-28.8 pg / ml
Woman 0-2.85 pg / ml
FSH (ECL) .......................... 18.86 Male: 1.4-18.1 mIU / ml U
Method: CHEMILUMINESCENCE Woman: foll.2.5-10.2 ovul.3.4-33.4
lutein. 1,5-9,1 menop. 23,0-116,3
LH (ECL) ........................... 30.40 Man: 1.5-9.3 mIU / ml U
Method: CHEMILUMINESCENCE Woman: foll. 1.9-12.5 ovul.8.7-76.3
lutein. 0.5-16.9 menop.7.9-53.8
PROLACTIN (ECL) ................... 14.74 Man: 2.1-17.7 ng / ml Woman: 2.8-29.2 U
Method: CHEMILUMINESCENCE pregnancy: 9.7 -208.5 ng / ml
menopause: 1.8-20.3 ng / ml
E2-17 BETAHEXTRADIOL ................ 54.03 Man: <39.8 pg / ml U
Method: CHEMILUMINESCENCE Woman: foll.19.5-144.2 ovul.63.9-357
lutein.:55.8-214.2 menop.:<32.2
DHT-DIIDROTESTOSTERONE ............. 543.00 Man: 250-990 pg / ml A
Method: ELISA Premenopausal woman: 24-368 pg / ml
Postmenopausal woman: 10-181 pg / ml
SHBG ............................... 35.58 Male: 14.55 - 113.13 nmol / L A
Method: ELECTRO-CHEMILUMINESCENCE Premenopausal woman: 10.84-> 180
Postmenopausal woman: 23.15-159.07
Hello, how are you? I was passing through.
You are on a regimen composed basically of Dutasteride and Bicalutamide, these estrogen levels do not make much difference in your body systematically, as your clinical exams show, Your SHBG shows me that you have low circulating estrogen. You have values within the normal range of testosterone and high levels of FSH LH hormones that signal production testosterone hormone for the testes.
We talked a lot about this here in the past, this topic already has more than 1000 pages, and I think that all knowledge is already there, at least from what we have available today, we have exhausted the literature here.
You by nature are XY, your body has AR receptors, and adaptations of your own sex to maintain your perfect homeostasis.
You are on a testosterone spike as dutasteride and bicalutamide raise your basal testosterone level, as DHT does not bind to the receptor due to the drugs the body understands it has no DHT because it has no testosterone and starts FSH-LH-Testosrone FEEDBACK.
All this hormonal medication is a test in the dark, it will vary for each patient, we are talking about the currents that control your body, and we are dealing with them, this is very dangerous, blocking your AR receptors completely can cause death, yes it is serious, but I think you all know what you're doing.
Your regimen needs a dose of estrogen to suppress your endogenous testosterone production, as you are on this route.
You have testosterone spikes and your body is transforming into DHT in the same way, the correct thing would be to increase the dose of duta, but I wouldn't do that, it will increase your testosterone levels even more, and there will be patients who will present the same , a paroxysmal hyperandrogenicity, ie even taking 5ar inhibitors (finasteride and dutastaride) will have such large peaks of testosterone that the body adapts to continue producing DHT.
The correct way to zero your DHT is with estrogen levels.
But that's a complete TRANS MTF scheme, and even then you might not get the result. But you can try.
I have never seen recovery with BICA and finasteride or dutasteride alone. Just an Indian wearer, only he was never bald, it was like maintenance.
Apart from this Indian, who has never been bald and there has been no regrowth, all users of bicalutamide who have had results have been in conjunction with another drug of estrogenic or prostagenic origin. I've been on this forum for a long time, and I've used bicalutamide alone as finasteride as well as several others from my time, it didn't work.
But you can try, why not.
