there is a study on gyno with spironolactone, with 100mg there is 11% chance of developing really mild gyno (mainly puffy nipples), with 200mg it increases to 50%.Why? Spironolactone induces gynecomastia by decreasing testosterone production so you are advocating getting more stress on the kidneys than using a natural estrogen which will both induce gyno? I fail to follow your broscience logic here.
I'd increase my dose to 150 before adding e2 (low dose, and probably EOD). I think of it as baby steps.
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